2019
May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension
Beaney T, Burrell L, Castillo R, Charchar F, Cro S, Damasceno A, Kruger R, Nilsson P, Prabhakaran D, Ramirez A, Schlaich M, Schutte A, Tomaszewski M, Touyz R, Wang J, Weber M, Poulter N, Burazeri G, Qirjako G, Roshi E, Cunashi R, Fernandes M, Pereira S, Neto M, Oliveira P, Feijão A, Cerniello Y, Marin M, Vasquez F, Espeche W, Stisman D, Fuentes I, Zilberman J, Rodriguez P, Babinyan K, Engibaryan A, Avagyan A, Minasyan A, Gevorkyan A, Carnagarin R, Carrington M, Sharman J, Lee R, Perl S, Niederl E, Malik F, Choudhury S, Al Mamun M, Ishraquzzaman M, Anthony F, Connell K, De Backer T, Krzesinski J, Houenassi M, Houehanou C, Sokolovic S, Bahtijarevic R, Tiro M, Mosepele M, Masupe T, Barroso W, Gomes M, Feitosa A, Brandão A, Miranda R, Azevedo V, Dias L, Garcia G, Martins I, Dzudie A, Kingue S, Djomou F, Njume E, Khan N, Lanas F, Garcia M, Paccot M, Torres P, Li Y, Liu M, Xu L, Li L, Chen X, Deng J, Zhao W, Fu L, Zhou Y, Lopez-Jaramillo P, Otero J, Camacho P, Accini J, Sanchez G, Arcos E, M’Buyamba-Kabangu J, Katamba F, Ngoyi G, Buila N, Bayauli P, Mbolla B, Bakekolo P, Landa C, Kaky G, Kramoh E, Ngoran Y, Olsen M, Valoy L, Santillan M, Rafael G, Peñaherrera C, Villalba J, Ramirez M, Arteaga F, Delgado P, Beistline H, Cappuccio F, Keitley J, Tay T, Goshu D, Kassie D, Gebru S, Pathak A, Denolle T, Tsinamdzgvrishvili B, Trapaidze D, Sturua L, Abesadze T, Grdzelidze N, Grabfelder M, Krämer B, Schmeider R, Twumasi-Ankrah B, Tannor E, Lincoln M, Deku E, Quintana F, Kenerson J, Baptiste E, Saintilmond W, Barrientos A, Peiger B, Lagos A, Forgas M, Lee V, Tomlinson B, Járai Z, Páll D, More A, Maheshwari A, Verma N, Sharma M, Mukherjee T, Patil M, Jose A, More A, Takalkar A, Turana Y, Widyantoro B, Danny S, Djono S, Handari S, Tambunan M, Tiksnadi B, Hermiawaty E, Tavassoli E, Zolfaghari M, Dolan E, O'Brien E, Borghi C, Ferri C, Torlasco C, Parati G, Nwokocha C, Nwokocha M, Ogola E, Gitura B, Barasa A, Barasa F, Wairagu A, Nalwa W, Najem R, Abu Alfa A, Fageh H, Msalam O, Derbi H, Bettamar K, Zakauskiene U, Vickiene A, Calmes J, Alkerwi A, Gantenbein M, Ndhlovu H, Masiye J, Chirwa M, Nyirenda N, Dhlamini T, Chia Y, Ching S, Devaraj N, Ouane N, Fane T, Kowlessur S, Ori B, Heecharan J, Alcocer L, Chavez A, Ruiz G, Espinosa C, Gomez-Alvarez E, Neupane D, Bhattarai H, Ranabhat K, Adhikari T, Koirala S, Toure I, Soumana K, Wahab K, Omotoso A, Sani M, Okubadejo N, Nadar S, Al-Riyami H, Ishaq M, Memon F, Sidique S, Choudhry H, Khan R, Ayala M, Maidana A, Bogado G, Ona D, Atilano A, Granada C, Bartolome R, Manese L, Mina A, Dumlao M, Villaruel M, Gomez L, Jóźwiak J, Małyszko J, Banach M, Mastej M, de Carvalho Rodrigues M, Martins L, Paval A, Dorobantu M, Konradi A, Chazova I, Rotar O, Spoares M, Viegas D, Almustafa B, Alshurafa S, Brady A, Bovet P, Viswanathan B, Oladapo O, Russell J, Brguljan-Hitij J, Bozic N, Knez J, Dolenc P, Hassan M, Woodiwiss A, Myburgh C, Vally M, Ruilope L, Molinero A, Rodilla E, Gijón-Conde T, Beheiry H, Ali I, Osman A, fahal N, Osman H, Altahir F, Persson M, Wuerzner G, Burkard T, Wang T, Lin H, Pan H, Chen W, Lin E, Mondo C, Ingabire P, Khomazyuk T, Krotova V, Negresku E, Evstigneeva O, Bazargani N, Agrawal A, Bin Belaila B, Suhail A, Muhammed K, Shuri H, Wainford R, Levy P, Boggia J, Garré L, Hernandez-Hernandez R, Octavio-Seijas J, Lopez-Rivera J, Morr I, Duin A, Huynh M, Cao S, Nguyen V, To M, Phan H, Cockroft J, McDonnell B, Goma F, Syatalimi C, Chifamba J, Gwini R, Tiburcio O, Xia X. May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension. European Heart Journal 2019, 40: 2006-2017. PMID: 31041440, PMCID: PMC6600128, DOI: 10.1093/eurheartj/ehz300.Peer-Reviewed Original ResearchConceptsMay Measurement MonthBlood pressureAntihypertensive medicationsMeasurement MonthDiastolic blood pressureSystolic blood pressureHigh blood pressureSystematic screening programmeMore participantsMMM 2018Untreated hypertensionBP readingsFormal screeningBP measurementsDisease burdenMultiple imputationHypertensionScreening programMedicationsMmHgInternational SocietyMonthsScreening campaignParticipantsIndividuals
2015
Hypertensive Encephalopathy and Renal Failure in a Young Man
Hunter RW, Dominiczak AF, Alwakeel J, Staessen JA, Jennings GL, Abu-Alfa AK, Webb DJ, Dhaun N. Hypertensive Encephalopathy and Renal Failure in a Young Man. Hypertension 2015, 67: 6-13. PMID: 26597825, DOI: 10.1161/hypertensionaha.115.06651.Peer-Reviewed Case Reports and Technical Notes
2014
Advancing pharmacovigilance through academic–legal collaboration: the case of gadolinium-based contrast agents and nephrogenic systemic fibrosis—a research on adverse drug events and reports (RADAR) report
Edwards BJ, Laumann AE, Nardone B, Miller FH, Restaino J, Raisch DW, McKoy JM, Hammel JA, Bhatt K, Bauer K, Samaras AT, Fisher MJ, Bull C, Saddleton E, Belknap SM, Thomsen HS, Kanal E, Cowper SE, Abu Alfa AK, West DP. Advancing pharmacovigilance through academic–legal collaboration: the case of gadolinium-based contrast agents and nephrogenic systemic fibrosis—a research on adverse drug events and reports (RADAR) report. British Journal Of Radiology 2014, 87: 20140307. PMID: 25230161, PMCID: PMC4170864, DOI: 10.1259/bjr.20140307.Peer-Reviewed Original ResearchConceptsGadolinium-based contrast agentsAdverse drug eventsDrug eventsMedicines AgencyGadopentetate dimeglumineDrug Administration Adverse Event Reporting SystemAdverse Event Reporting SystemDanish Medicines AgencyNephrogenic systemic fibrosisEvent Reporting SystemEuropean Medicines AgencyNSF casesHistopathological dataContrast agentsSystemic fibrosisDrug AdministrationLegal data setsUnconfounded casesGadobenate dimeglumineMean numberDimeglumineReporting systemPharmacovigilance researchSafety informationPharmacovigilance
2013
Pediatric nephrogenic systemic fibrosis is rarely reported: a RADAR report
Nardone B, Saddleton E, Laumann AE, Edwards BJ, Raisch DW, McKoy JM, Belknap SM, Bull C, Haryani A, Cowper SE, Abu-Alfa AK, Miller FH, Godinez-Puig V, Dharnidharka VR, West DP. Pediatric nephrogenic systemic fibrosis is rarely reported: a RADAR report. Pediatric Radiology 2013, 44: 173-180. PMID: 24057195, PMCID: PMC3946726, DOI: 10.1007/s00247-013-2795-x.Peer-Reviewed Original ResearchConceptsNephrogenic systemic fibrosisSystemic fibrosisGadolinium-based contrast agentsDrug Administration Adverse Event Reporting SystemAdverse Event Reporting SystemEvent Reporting SystemRenal functionPediatric casesResearch RegistryContrast agentsFibrosisDuplicate reportingU.S. FoodSystematic searchReported numberRegistryChildrenReporting systemFAERSExposureReportAgentsMethodsWeCasesAcute Kidney Injury and Bisphosphonate Use in Cancer: A Report From the Research on Adverse Drug Events and Reports (RADAR) Project
Edwards BJ, Usmani S, Raisch DW, McKoy JM, Samaras AT, Belknap SM, Trifilio SM, Hahr A, Bunta AD, Abu-Alfa A, Langman CB, Rosen ST, West DP. Acute Kidney Injury and Bisphosphonate Use in Cancer: A Report From the Research on Adverse Drug Events and Reports (RADAR) Project. JCO Oncology Practice 2013, 9: 101-106. PMID: 23814519, PMCID: PMC3595436, DOI: 10.1200/jop.2011.000486.Peer-Reviewed Original ResearchConceptsAcute kidney injuryZoledronic acidKidney injuryAdverse eventsProportional reporting ratioFDA AERSBisphosphonate useSafety signalsReporting ratioAdverse drug eventsDrug Administration adverse eventsAdverse drug reactionsCancer clinical trialsPremorbid diseaseRenal injuryRenal problemsMean ageMultiple myelomaDrug eventsDrug reactionsClinical trialsProstate cancerBreast cancerCancer settingUS Food
2012
Non-Uremic Calcific Arteriolopathy (Calciphylaxis) in Relapsed/Refractory Hodgkin's Lymphoma: A Previously Unreported Association
Sibai H, Ishak RS, Halawi R, Otrock ZK, Salman S, Abu-Alfa A, Kharfan-Dabaja MA. Non-Uremic Calcific Arteriolopathy (Calciphylaxis) in Relapsed/Refractory Hodgkin's Lymphoma: A Previously Unreported Association. Journal Of Clinical Oncology 2012, 30: e88-e90. PMID: 22231039, DOI: 10.1200/jco.2011.39.4551.Peer-Reviewed Case Reports and Technical Notes
2010
Experience with outpatient computed tomographic-guided renal biopsy.
Margaryan A, Perazella MA, Mahnensmith RL, Abu-Alfa AK. Experience with outpatient computed tomographic-guided renal biopsy. Clinical Nephrology 2010, 74: 440-5. PMID: 21084047, DOI: 10.5414/cnp74440.Peer-Reviewed Original ResearchConceptsNative kidney biopsiesKidney biopsyRenal biopsyPost-biopsy observation periodInpatient observation periodObservation periodLow complication rateTime of admissionYale-New Haven Medical CenterDuration of procedureInstances of deathHemoglobin concentration changesDetectable bleedingSerum creatinineComplication rateMean ageRenal sizeAdequate tissueMedical CenterOutpatient unitDiagnostic tissueBiopsyLaboratory dataTransfusionPatients
2009
Gadolinium‐containing magnetic resonance image contrast agent promotes fibrocyte differentiation
Vakil V, Sung JJ, Piecychna M, Crawford JR, Kuo P, Abu‐Alfa A, Cowper SE, Bucala R, Gomer RH. Gadolinium‐containing magnetic resonance image contrast agent promotes fibrocyte differentiation. Journal Of Magnetic Resonance Imaging 2009, 30: 1284-1288. PMID: 19937928, PMCID: PMC2787835, DOI: 10.1002/jmri.21800.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsNephrogenic systemic fibrosisSerum amyloid PFibrocyte differentiationDifferentiation of monocytesNSF patientsBlood mononuclear cellsHemodialysis patientsInterleukin-12Mononuclear cellsPurified monocytesFibroblast-like cellsFibrotic lesionsHealthy controlsSystemic fibrosisAmyloid PContrast agentsPatientsMonocytesDifferentiation inhibitorWiley-LissFibrocytesOmniscanDifferentiation protocolsCells
2008
The Association of Hashimoto Disease and Congo Red Negative Amyloidosis
Chaiban JT, Kalache SM, Salti I, Abu Alfa A, Shabb N. The Association of Hashimoto Disease and Congo Red Negative Amyloidosis. The American Journal Of The Medical Sciences 2008, 336: 293-296. PMID: 18794630, DOI: 10.1097/maj.0b013e31815b9d51.Peer-Reviewed Original ResearchConceptsCongo red stainHashimoto's thyroiditisPrimary amyloidosisMultiple organ involvementRed stainMonoclonal immunoglobulin light chainsOrgan involvementRenal failureHeart failureHashimoto's diseaseAmyloid depositionEnlarged tongueRare caseImmunoglobulin light chainsSystemic amyloidosisExtracellular depositionImmunofixation studiesAmyloidosisUltrastructural featuresThyroiditisPatientsLight chainStainEarly stagesBiopsyThe association of darbepoetin alfa with hemoglobin and health-related quality of life in patients with chronic kidney disease not receiving dialysis*
Abu-Alfa AK, Sloan L, Charytan C, Sekkarie M, Scarlata D, Globe D, Audhya P. The association of darbepoetin alfa with hemoglobin and health-related quality of life in patients with chronic kidney disease not receiving dialysis*. Current Medical Research And Opinion 2008, 24: 1091-1100. PMID: 18328118, DOI: 10.1185/030079908x280653.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseErythropoiesis-stimulating agentsHealth-related qualityDarbepoetin alfaWeek 52Week 12Kidney diseasePatients' health-related qualityGeneral CKD populationQ2W darbepoetin alfaWeek darbepoetin alfaGlomerular filtration rateSingle-arm studyBenefits of treatmentMean Hb concentrationYears of ageSubject inclusion criteriaCKD populationCreatinine clearanceHemoglobin levelsHb targetHb levelsHRQOL measuresFiltration rateInclusion criteria
2007
Are Patients with Moderate Renal Failure at Risk for Developing Nephrogenic Systemic Fibrosis?
Saab G, Abu-Alfa A. Are Patients with Moderate Renal Failure at Risk for Developing Nephrogenic Systemic Fibrosis? Radiology 2007, 244: 930-932. PMID: 17709844, DOI: 10.1148/radiol.2443070351.Peer-Reviewed Original ResearchWill dialysis prevent the development of nephrogenic systemic fibrosis after gadolinium-based contrast administration?
Saab G, Abu-Alfa A. Will dialysis prevent the development of nephrogenic systemic fibrosis after gadolinium-based contrast administration? American Journal Of Roentgenology 2007, 189: w169. PMID: 17715089, DOI: 10.2214/ajr.07.2252.Peer-Reviewed Original Research
2006
Long‐term comparison of sevelamer hydrochloride to calcium‐containing phosphate binders
BREWSTER UC, CIAMPI MA, ABU‐ALFA A, REILLY RF. Long‐term comparison of sevelamer hydrochloride to calcium‐containing phosphate binders. Nephrology 2006, 11: 142-146. PMID: 16669977, DOI: 10.1111/j.1440-1797.2006.00544.x.Peer-Reviewed Original ResearchConceptsCalcium-containing bindersSerum phosphorus concentrationLower serum bicarbonate concentrationEnd-stage renal diseaseCalcium-phosphorus productSerum bicarbonate concentrationSevelamer hydrochloridePhosphate bindersCalcium-containing phosphate bindersElevated calcium-phosphorus productHigher serum phosphorus concentrationsMmol2/L2Retrospective chart reviewLong-term efficacyCa-P productLong-term comparative studiesBicarbonate concentrationESRD patientsChart reviewRenal diseaseCalcium loadPatientsLong-term comparisonTarget goalsEfficacy
2004
Superiority of Icodextrin Compared with 4.25% Dextrose for Peritoneal Ultrafiltration
Finkelstein F, Healy H, Abu-Alfa A, Ahmad S, Brown F, Gehr T, Nash K, Sorkin M, Mujais S, Group O. Superiority of Icodextrin Compared with 4.25% Dextrose for Peritoneal Ultrafiltration. Journal Of The American Society Of Nephrology 2004, 16: 546-554. PMID: 15625070, DOI: 10.1681/asn.2004090793.Peer-Reviewed Original ResearchConceptsIcodextrin groupNegative net ultrafiltrationNet ultrafiltrationPeritoneal ultrafiltrationWeek 2Week 1Control groupDouble-blind trialPercentage of patientsAutomated Peritoneal DialysisPeritoneal dialysisTreatment groupsControlled EvaluationHigh transportersClinical observationsIcodextrinStudy periodBaselineLong dwellPatientsDextroseSolute removalGroupEfficiency ratioMulticenterCinacalcet for Secondary Hyperparathyroidism in Patients Receiving Hemodialysis
Block GA, Martin KJ, de Francisco AL, Turner SA, Avram MM, Suranyi MG, Hercz G, Cunningham J, Abu-Alfa AK, Messa P, Coyne DW, Locatelli F, Cohen RM, Evenepoel P, Moe SM, Fournier A, Braun J, McCary LC, Zani VJ, Olson KA, Drüeke TB, Goodman WG. Cinacalcet for Secondary Hyperparathyroidism in Patients Receiving Hemodialysis. New England Journal Of Medicine 2004, 350: 1516-1525. PMID: 15071126, DOI: 10.1056/nejmoa031633.Peer-Reviewed Original ResearchConceptsParathyroid hormone levelsPrimary end pointSecondary hyperparathyroidismHormone levelsPlacebo groupCinacalcet groupLow parathyroid hormone levelsSerum calcium-phosphorus productIntact parathyroid hormone levelsEnd pointCalcium-phosphorus productEfficacy assessment phaseParathyroid hormone valuesPatients Receiving HemodialysisPlacebo-controlled trialPercentage of patientsAdverse clinical outcomesCalcium-phosphorus homeostasisCalcium-sensing receptorClinical outcomesVitamin DDaily dosesStandard treatmentHormone valuesCardiovascular disease
2003
Addition of sertraline to other therapies to reduce dialysis‐associated hypotension
BREWSTER UC, CIAMPI MA, ABU‐ALFA A, PERAZELLA MA. Addition of sertraline to other therapies to reduce dialysis‐associated hypotension. Nephrology 2003, 8: 296-301. PMID: 15012700, DOI: 10.1111/j.1440-1797.2003.00216.x.Peer-Reviewed Original ResearchConceptsDialysis-associated hypotensionCentral blood volumePeripheral vascular resistanceBlood pressureCardiac outputBlood volumeEnd-stage renal disease patientsInitiation of dialysisRenal disease patientsDiastolic blood pressureSystolic blood pressureEffects of sertralineTermination of dialysisAddition of sertralineUltrasound dilution techniqueVascular resistanceArterial pressureHaemodynamic measurementsDisease patientsPatientsControl phaseSertralineTherapyDialysisHypotensionVascular Access Surveillance: Evaluation of Combining Dynamic Venous Pressure and Vascular Access Blood Flow Measurements
Hoeben H, Abu-Alfa AK, Reilly RF, Aruny JE, Bouman K, Perazella MA. Vascular Access Surveillance: Evaluation of Combining Dynamic Venous Pressure and Vascular Access Blood Flow Measurements. American Journal Of Nephrology 2003, 23: 403-408. PMID: 14566106, DOI: 10.1159/000074297.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaArteriovenous graftsThrombosis rateThrombotic eventsVascular accessAccess blood flow measurementsSurveillance protocolBlood flow measurementsHemodialysis patientsVenous pressureDynamic venous pressureVascular access thrombosisChronic hemodialysis patientsAccess thrombosisEarly repairIntervention ratesBACKGROUND/Cutoff levelMorbid problemPatientsLow specificityAccess yearCombined monitoringStenosisThrombosisImplications of the ADEMEX Trial
Mujais S, Vonesh E, Abu-Alfa A. Implications of the ADEMEX Trial. Contributions To Nephrology 2003, 140: 131-141. PMID: 12800353, DOI: 10.1159/000071433.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2002
Observations on HIV-Associated Renal Disease in the Era of Highly Active Antiretroviral Therapy
Cosgrove CJ, Abu-Alfa AK, Perazella MA. Observations on HIV-Associated Renal Disease in the Era of Highly Active Antiretroviral Therapy. The American Journal Of The Medical Sciences 2002, 323: 102-106. PMID: 11863077, DOI: 10.1097/00000441-200202000-00009.Peer-Reviewed Original ResearchConceptsHIV-associated nephropathyActive antiretroviral therapySerum creatinineRenal functionRenal diseaseRenal outcomesAntiretroviral therapyViral loadRenal lesionsHighly Active Antiretroviral TherapyAngiotensin-converting enzyme inhibitorEffect of HAARTNon-HAART groupAdvanced renal failureInitiation of dialysisRenal function parametersStable renal functionVariety of lesionsHAART groupCD4 countHAART eraRenal evaluationRenal insufficiencyRenal ultrasoundBaseline characteristics
2001
Treatment of Severe Intradialytic Hypotension With the Addition of High Dialysate Calcium Concentration to Midodrine and/or Cool Dialysate
Alappan R, Cruz D, Abu-Alfa A, Mahnensmith R, Perazella M. Treatment of Severe Intradialytic Hypotension With the Addition of High Dialysate Calcium Concentration to Midodrine and/or Cool Dialysate. American Journal Of Kidney Diseases 2001, 37: 294-299. PMID: 11157369, DOI: 10.1053/ajkd.2001.21292.Peer-Reviewed Original ResearchConceptsHigh dialysate calcium concentrationSevere intradialytic hypotensionDialysate calcium concentrationIntradialytic hypotensionBlood pressureEnd-stage renal disease populationCalcium concentrationLow dialysate calciumSeverity of hypotensionMean arterial pressurePeripheral vascular resistanceIntradialytic blood pressureRenal disease populationProspective crossover studyTreatment of patientsMultiple pathogenic factorsType of therapyDialysate calciumHemodynamic instabilityVascular resistanceHemodynamic stabilityArterial pressureCrossover studyCardiac outputCool dialysate