Center Publications

Our members are consistently collaborating and publishing relevant studies and findings focused on the Liver.

Publication Acknowledgment

To cite the Liver Center in your publications please use the following statement:

”This project was supported in part by the Yale Liver Center award NIH P30 DK034989 ________ core.”
(insert name of core(s) that you used-Morphology, Cellular Molecular, Clinical-Translational)

Liver Center Publications

Applying flow cytometry-based isolation of platelet-derived microparticles to banked human plasma for cellular studies.Fattahi N, Tyagi T, Kirlin F, Flores AL, Hwa J, Iwakiri Y, McConnell MJ. J Pathol. 2026 Oct; 2026 Jul 14. PMID: 42446223.
Liver disease reveals KIF12 as a regulator of mitochondria, lysosome and cilia localisation in human cholangiocytes.Seth A, Brancale J, Dashti-Gibson N, Florentino RM, Faccioli LAP, Liu Z, Konkwo C, Hong H, Soto-Gutierrez A, Vilarinho S. EBioMedicine. 2026 Sep 11; 2026 Sep 11. PMID: 42727250.
Platelet-derived S100A9 contributes to endotheliopathy in alcohol-associated hepatitis.Kirlin F, Fattahi N, Garcia-Milian R, Collin F, Wang W, Kim Y, Lucien F, Sun Z, Lam TT, Hwa J, Iwakiri Y, McConnell MJ. JCI Insight. 2026 Aug 24; 2026 Aug 24. PMID: 42635042.
Internalized components of membrane attack complexes disrupt proteostasis and acquire alarmin-like properties.Song G, Ma Z, Fan M, He L, Lan Y, Li W, Jiang Z, Jiang Q, Noone DP, Nans A, Nahas KL, Barkestani MN, Wang S, Wang Q, Ren P, Cheng J, Zang Y, Zhou H, Johnson J, Mullan C, Gong X, Bubeck D, Moeckel G, Mak M, Tellides G, Jane-Wit D. Nat Commun. 2026 Jul 17; 2026 Jul 17. PMID: 42469261.
Machine learning modeling to predict HCC locations in cirrhotic patients undergoing MRI - a proof-of-concept study.Gaddum O, Zeevi T, Dai W, Lin M, Thomas S, Tefera J, Sobirey R, Matuschewski NJ, Gross M, Abosabie SA, Abosabie SAS, Gebauer B, Savic LJ, Madoff DC, Duncan JS, Chapiro J. Abdom Radiol (NY). 2026 Jul 13; 2026 Jul 13. PMID: 42440113.
Optical photothermal infrared imaging of fatty acid esterification in the ER of living cells.Castillo HB, Davis CM. Sci Adv. 2026 Jul 10; 2026 Jul 8. PMID: 42418595.
Internalized Components of Membrane Attack Complexes Disrupt Proteostasis and Acquire Alarmin-Like Properties.Song G, Ma Z, Fan M, He L, Lan Y, Li W, Jiang Z, Jiang Q, Noone DP, Nans A, Nahas KL, Barkestani MN, Wang S, Wang Q, Ren P, Cheng J, Zang Y, Zhou H, Johnson J, Mullan C, Gong X, Bubeck D, Moeckel G, Mak M, Tellides G, Jane-Wit D. bioRxiv. 2026 Jul 3; 2026 Jul 3. PMID: 42427641.
Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine.Xiong Y, Tomares DT, Guo J, Sato K, Zeng L, Tian Y, Su M, Albis A, Pant A, Pappu RV, Su X. Nat Chem Biol. 2026 Jul; 2026 Feb 27. PMID: 41760814.
CIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity.Sakuma I, Gaspar RC, Morgan HN, Zheng J, Nasiri AR, Dufour S, Kahn M, Guerra MT, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner DF, Petersen KF, Samuel VT, Tanaka T, Shulman GI. Cell Rep. 2026 Jun 23; 2026 Jun 3. PMID: 42234563.
Regulation of chromatin dynamics by a calcium-dependent nucleoskeleton.González MJ, Rodrigues MA, Diprima S, Zhao D, Bassani TF, Fernandez CC, Kruglov E, Nathanson MH, Gomes DA. J Biol Chem. 2026 Jun; 2026 May 6. PMID: 42103234.
Insulin receptor(T1160) phosphorylation mediates renal cortical insulin resistance but not excess gluconeogenesis from glycerol.Hubbard BT, Ma Y, Gaspar RC, LaMoia TE, Zhang D, Kahn M, Dufour S, Nasiri A, Shulman GI. Nat Commun. 2026 May 21; 2026 May 21. PMID: 42168167.
Optical photothermal infrared imaging of fatty acid esterification in the ER of living cells.Castillo HB, Davis CM. bioRxiv. 2026 Mar 23; 2026 Mar 23. PMID: 41573870.
Pathophysiology of cystic fibrosis-related liver disease.Palmiotti A, Bertolini A, Fiorotto R. Curr Opin Gastroenterol. 2026 Mar 1; 2025 Dec 29. PMID: 41461020.
IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers.Zhang X, Xiao Q, Zeng L, Hashmi F, Sato K, Hartwich TMP, Mansolf M, Yang-Hartwich Y, Su X. Nat Chem Biol. 2026 Mar; 2025 Sep 29. PMID: 41023404.
A liquid biopsy-RNAseq method for monitoring the expression of genes involved in drug disposition: Proof-of-concept application to cholestatic liver disease.Dahal A, Sierra T, Hayes CM, Assis DN, Rostami-Hodjegan A, Ghonem NS, Achour B. J Pharm Biomed Anal. 2026 Feb 15; 2025 Nov 10. PMID: 41240411.
Mast cell extracellular granules are bioactive condensates driven by heparin and polyamine.Xiong Y, Tomares DT, Guo J, Sato K, Zeng L, Tian Y, Su M, Albis A, Pant A, Pappu RV, Su X. bioRxiv. 2025 Dec 26; 2025 Dec 26. PMID: 41497591.
Overcoming Immune Exclusion in a Murine Model of Cirrhotic Hepatocellular Carcinoma via Cryoablation: Insights from Molecular Extracellular pH Imaging.Coman D, Santana JG, Shewarega A, Nam D, Löffler ML, Kao T, Zhang X, Kahl V, Hyder F, Chapiro J. Res Sq. 2025 Dec 3; 2025 Dec 3. PMID: 41377976.
Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs-PKCε-insulin receptor kinase(T1150) pathway.Zheng J, Gaspar RC, Sakuma I, Hubbard BT, Zhang D, Nasiri A, Kahn M, Perelis M, Samuel VT, Petersen KF, Shulman GI. Diabetologia. 2025 Dec; 2025 Sep 4. PMID: 40908405.
TET3 is a common epigenetic immunomodulator of pathogenic macrophages.Liu B, Dai Y, Wang Z, Song J, Du Y, Lv H, Bellone S, Yang YH, Kennedy A, Zhang S, Venkatachalapathy M, Surovtseva Y, Wang P, Carmichael GG, Taylor HS, Zhang X, Li D, Huang Y. J Clin Invest. 2025 Nov 3; 2025 Aug 12. PMID: 40794443.
CFTR High Expresser BEST4(+) cells are pH-sensing neuropod cells: new implications for intestinal physiology and cystic fibrosis disease.Dos Reis DC, Jin J, Santos A, Dastoor P, Muiler C, Zagoren E, Donnelley M, Parsons D, Cmielewski P, Reyne N, McCarron A, Smith Z, Sumigray K, Ameen NA. Am J Physiol Cell Physiol. 2025 Nov 1; 2025 Sep 26. PMID: 41005986.
CD8 T cells mediate immunosurveillance for neoantigen+ epithelial stem cells in the colon.Buck J, Iyer NR, Fagerberg E, Micevic G, He J, St Denis K, Shah V, Blackburn HN, Venkatesan S, Attanasio J, Hunt BG, Dalrymple A, Konnikova L, Beyaz S, Damo M, Booth CJ, Connolly KA, Joshi NS. bioRxiv. 2025 Oct 19; 2025 Oct 19. PMID: 41280049.
GLP-1 receptor agonism results in reduction in hepatic ethanol metabolism.Zahrawi F, Suyavaran A, Banini BA, Mehal WZ. NPJ Metab Health Dis. 2025 Sep 18; 2025 Sep 18. PMID: 40968135.
Hyperactive PLCG1 induces cell-autonomous and bystander T cell activation and drug resistance.Zeng L, Zhang X, Xiong Y, Sato K, Hajicek N, Kogure Y, Kataoka K, Ogawa S, Sondek J, Su X. EMBO Rep. 2025 Sep; 2025 Aug 12. PMID: 40796680.
Hepatic ferredoxin reductase modulates mitochondrial function and iron homeostasis in metabolic dysfunction-associated steatotic liver disease.Tanaka T, Sakuma I, Gaspar R, Luukkonen P, Hubbard B, Vatner D, Nasiri A, Dufour S, Kahn M, Perelis M, Taki Y, Nakayama A, Fujimoto M, Kono T, Miki T, Yokote K, Petersen K, Samuel V, Shulman G. Res Sq. 2025 Aug 27; 2025 Aug 27. PMID: 40909793.
Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer.Gong X, Ogino N, Leite MF, Zhang D, Chen Z, Nguyen RY, Liu R, Kruglov E, Flores K, Cabral AT, Moreira de M Mendes G, Ehrlich BE, Mak M. Cancer Res. 2025 Aug 15. PMID: 40387600.
Noninvasive Tumor Profiling: Quantitative Contrast-Enhanced MRI Markers Predict PD-L1 and CTNNB1 Status in Hepatocellular Carcinoma.Matuschewski NJ, Sobirey R, Revzin M, Zeevi T, Gross M, Kasolowsky V, Shewarega A, Meister E, Kao T, Tefera J, Bousabarah K, Batra R, Strazzabosco M, Lin M, Gebauer B, Savic LJ, Duncan J, Madoff DC, Zhang X, Chapiro J. Radiology. 2025 Aug. PMID: 40762840.
Identification of medication-microbiome interactions that affect gut infection.Kumar A, Sun R, Habib B, Deng T, Bencivenga-Barry NA, Palm NW, Ivanov II, Tamblyn R, Goodman AL. Nature. 2025 Aug; 2025 Jul 16. PMID: 40670788.
Instant assembly of collagen for tissue engineering and bioprinting.Gong X, Wen Z, Liang Z, Xiao H, Lee S, Rossello-Martinez A, Xing Q, Wright T, Nguyen RY, Mak M. Nat Mater. 2025 Aug; 2025 Jun 6. PMID: 40481243.
New developments on the effects of alcohol use on immunity, inflammation and organ function: A summary of the 2024 Alcohol and Immunology Research Interest Group (AIRIG) meeting.Tschann MM, Vachharajani V, Redmond EM, Hoisington A, Cohen SE, New-Aaron M, Llorente C, Paloczi J, Keating CR, Rungratanawanich W, Burnham EL, Callaci JJ, Raju P, Zhong W, Mandal A, Zimmerly JR, Nuncio ASP, Mandrekar P, McCullough RL, McMahan RH, Wyatt TA, Yeligar SM, Kovacs EJ, Choudhry MA. Alcohol. 2025 Aug; 2025 Apr 21. PMID: 40267994.
CCL17 Influences Borrelia burgdorferi Infection in the Heart.Tang X, Yu Q, Cui Y, Hart TM, Rivas-Giorgi F, Calloway K, Mohapatra AR, Fikrig E. J Infect Dis. 2025 Jul 30. PMID: 39777514.
Insulin resistance, metabolic dysfunction-associated steatotic liver disease, and advanced liver fibrosis in lean US adults: a population-based study.Njei B, Abdu M, Al-Ajlouni YA, Mohamed MF, Deng Y, Osta EG, Kanmounye US, Vilarinho S, Dranoff J, Lim JK, Md, Echouffo Tcheugui JB. Proc (Bayl Univ Med Cent). 2025; 2025 Jul 10. PMID: 40821486.
The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour.Yoshida TM, Nguyen M, Zhang L, Lu BY, Zhu B, Murray KN, Mineur YS, Zhang C, Xu D, Lin E, Luchsinger J, Bhatta S, Waizman DA, Coden ME, Ma Y, Israni-Winger K, Russo A, Wang H, Song W, Al Souz J, Zhao H, Craft JE, Picciotto MR, Grutzendler J, Distasio M, Palm NW, Hafler DA, Wang A. Nature. 2025 Jul; 2025 May 28. PMID: 40437096.
Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury.Harris ZM, Korde A, Khoury J, Manning EP, Stanley G, Mitchell K, Sun Y, Hu B, Shin HJ, Joerns J, Clark B, Placek L, Unutmaz D, Moldobaeva A, Sharma L, Sauler M, Rajagopalan G, Zhang X, Wang H, Ghaedi M, Kang MJ, Koff JL. bioRxiv. 2025 May 23; 2025 May 23. PMID: 40475627.
Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice.Yu Q, Tang X, Hart T, Homer R, Belperron AA, Bockenstedt LK, Ring A, Nakamura A, Fikrig E. Elife. 2025 May 20; 2025 May 20. PMID: 40392222.
Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.Sakuma I, Gaspar RC, Nasiri AR, Dufour S, Kahn M, Zheng J, LaMoia TE, Guerra MT, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner DF, Petersen KF, Huttasch M, Knebel B, Kahl S, Roden M, Samuel VT, Tanaka T, Shulman GI. Proc Natl Acad Sci U S A. 2025 May 6; 2025 May 1. PMID: 40310463.
Targeting Polymeric Nanoparticles to Specific Cell Populations in the Liver.Harkins L, Vilarinho S, Saltzman WM. Biochemistry. 2025 Apr 15; 2025 Mar 24. PMID: 40127248.
Portal Fibrosis and the Ductular Reaction: Pathophysiological Role in the Progression of Liver Disease and Translational Opportunities.Gupta V, Sehrawat TS, Pinzani M, Strazzabosco M. Gastroenterology. 2025 Apr; 2024 Sep 7. PMID: 39251168.
Clinicopathologic features and prognosis of steatohepatitic hepatocellular carcinoma based on varying cutoffs of tumoral steatohepatitic changes.Zhang T, Niu N, Taddei T, Jain D, Zhang X. Am J Clin Pathol. 2025 Mar 8. PMID: 39418121.
Molecular MRI of T-cell immune response to cryoablation in immunologically hot vs. cold hepatocellular carcinoma.Santana JG, Shewarega A, Nam D, Duncan J, Madoff DC, Hyder F, Coman D, Chapiro J. JHEP Rep. 2025 Mar; 2024 Dec 4. PMID: 40028344.
Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages.Ma R, Gong L, Dong C, Utsumi T, Qi J, Zhuang ZW, Zhang X, Yang Y, McConnell MJ, Huang HC, Iwakiri Y. bioRxiv. 2025 Feb 6; 2025 Feb 6. PMID: 39975181.
Mortality, Hepatic Decompensation, and Cardiovascular Outcomes in Lean vs. Non-lean MASLD Cirrhosis: A Veterans Affairs Cohort Study.Njei B, Mezzacappa C, John BV, Serper M, Kaplan DE, Taddei TH, Mahmud N. Dig Dis Sci. 2025 Feb; 2025 Jan 8. PMID: 39779587.
CFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and Cystic Fibrosis disease.Dos Reis DC, Jin J, Santos A, Muiler C, Zagoren E, Donnelley M, Parsons D, Cmielewski P, Reyne N, McCarron A, Smith Z, Sumigray K, Ameen NA. bioRxiv. 2025 Jan 27; 2025 Jan 27. PMID: 39974899.
Liver Lymphatic Dysfunction as a Driver of Fibrosis and Cirrhosis Progression.Jeong J, Hsu SJ, Horikami D, Utsumi T, Yang Y, Arefyev N, Zhang X, Cai SY, Boyer JL, Garcia-Milan R, Tanaka M, McConnell MJ, Huang HC, Iwakiri Y. bioRxiv. 2025 Jan 14; 2025 Jan 14. PMID: 39868144.
mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae.Dolan B, Correa Gaviria T, Dong Y, Cresswell P, Dimopoulos G, Chuang YM, Fikrig E. Nat Commun. 2025 Jan 11; 2025 Jan 11. PMID: 39799117.
Second-Line Treatment for Patients With Primary Biliary Cholangitis: A Systematic Review With Network Meta-Analysis.Giannini EG, Pasta A, Calabrese F, Labanca S, Marenco S, Pieri G, Plaz Torres MC, Strazzabosco M. Liver Int. 2025 Jan. PMID: 39720853.
PPAR agonists for the treatment of cholestatic liver diseases: Over a decade of clinical progress.Hayes CM, Gallucci GM, Boyer JL, Assis DN, Ghonem NS. Hepatol Commun. 2025 Jan 1; 2024 Dec 20. PMID: 39699308.
Mitogen-Activated Protein Kinase Phosphatase-5 is Required for TGF-β Signaling Through a JNK-Dependent Pathway.Dorry S, Perla S, Bennett AM. Mol Cell Biol. 2025 Jan; 2024 Nov 28. PMID: 39607740.
Controversies regarding albumin therapy in cirrhosis.Trebicka J, Garcia-Tsao G. Hepatology. 2025 Jan 1; 2023 Aug 7. PMID: 37540192.
Hyperactive PLCG1 drives non-canonical signaling to promote cell survival.Zeng L, Zhang X, Xiong Y, Sato K, Hajicek N, Sondek J, Su X. bioRxiv. 2024 Dec 18; 2024 Dec 18. PMID: 39763946.
Hepatic Biliary Adenofibroma: Histological Characteristics, Diagnostic Challenges, and Its Role as a Precursor to Intrahepatic Cholangiocarcinoma.Liao X, Zhang X. J Clin Transl Pathol. 2024 Oct-Dec; 2024 Dec 24. PMID: 40026322.
CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study.Wang Y, Charkoftaki G, Orlicky DJ, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson DC, Vasiliou V, Chen Y. Arch Toxicol. 2024 Oct; 2024 Aug 27. PMID: 39192018.
Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation.LaMoia TE, Hubbard BT, Guerra MT, Nasiri A, Sakuma I, Kahn M, Zhang D, Goodman RP, Nathanson MH, Sancak Y, Perelis M, Mootha VK, Shulman GI. Cell Metab. 2024 Oct 1; 2024 Aug 16. PMID: 39153480.
RNA modifications in the progression of liver diseases: from fatty liver to cancer.Li S, Mehal WZ, Ouyang X. Sci China Life Sci. 2024 Oct; 2024 May 27. PMID: 38809498.
Automated graded prognostic assessment for patients with hepatocellular carcinoma using machine learning.Gross M, Haider SP, Ze'evi T, Huber S, Arora S, Kucukkaya AS, Iseke S, Gebauer B, Fleckenstein F, Dewey M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey JA. Eur Radiol. 2024 Oct; 2024 Mar 27. PMID: 38536464.
Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice.Bertolini A, Nguyen M, Zehra SA, Taleb SA, Bauer-Pisani T, Palm N, Strazzabosco M, Fiorotto R. J Hepatol. 2024 Sep; 2024 Mar 28. PMID: 38554847.
The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity.Marin-Lopez A, Huck JD, Esterly AT, Azcutia V, Rosen C, Garcia-Milian R, Sefik E, Vidal-Pedrola G, Raduwan H, Chen TY, Arora G, Halene S, Shaw AC, Palm NW, Flavell RA, Parkos CA, Thangamani S, Ring AM, Fikrig E. Sci Immunol. 2024 Aug 9; 2024 Aug 9. PMID: 39121194.
Automated MRI liver segmentation for anatomical segmentation, liver volumetry, and the extraction of radiomics.Gross M, Huber S, Arora S, Ze'evi T, Haider SP, Kucukkaya AS, Iseke S, Kuhn TN, Gebauer B, Michallek F, Dewey M, Vilgrain V, Sartoris R, Ronot M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey JA. Eur Radiol. 2024 Aug; 2024 Jan 13. PMID: 38217704.
Systematic Review and Meta-Analysis of Urine Neutrophil Gelatinase-Associated Lipocalin for Acute Kidney Injury in Cirrhosis.Puthumana J, Lugon NC, Xu Y, Deng Y, Mistry PK, Parikh CR. Kidney Int Rep. 2024 Jul; 2024 May 3. PMID: 39081737.
Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features.Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, Graham M, Liu X, McConnell MJ, Utsumi T, Pereira J, Iwakiri Y. JHEP Rep. 2024 Jul; 2024 Mar 18. PMID: 38966234.
Electrocardiographic abnormalities in patients with metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis.Dimala CA, Nso N, Wasserlauf J, Njei B. Curr Probl Cardiol. 2024 Jul; 2024 Apr 21. PMID: 38653446.
MAPK Phosphatase-5 is required for TGF-β signaling through a JNK-dependent pathway.Dorry S, Perla S, Bennett AM. bioRxiv. 2024 Jun 27; 2024 Jun 27. PMID: 38979264.
Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis.Ogino N, Leite MF, Guerra MT, Kruglov E, Asashima H, Hafler DA, Ito T, Pereira JP, Peiffer BJ, Sun Z, Ehrlich BE, Nathanson MH. J Clin Invest. 2024 Jun 25; 2024 Jun 25. PMID: 38916955.
Complement Membrane Attack Complexes Disrupt Proteostasis to Function as Intracellular Alarmins.Jane-Wit D, Song G, He L, Jiang Q, Barkestani M, Wang S, Wang Q, Ren P, Fan M, Johnson J, Mullan C. Res Sq. 2024 Jun 19; 2024 Jun 19. PMID: 38947095.
Cost-effectiveness analysis: The missing factor in the management of HCC.Njei B, Yi I, Strazzabosco M. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 Jun 7. PMID: 38860130.
Safety and Efficacy of Atezolizumab/Bevacizumab in Patients with Hepatocellular Carcinoma and Impaired Liver Function: A Systematic Review and Meta-Analysis.Pasta A, Calabrese F, Jaffe A, Labanca S, Marenco S, Pieri G, Plaz Torres MC, Strazzabosco M, Giannini EG. Liver Cancer. 2024 Jun; 2023 Oct 14. PMID: 38756146.
Cardiovascular morbidity and mortality in lean vs. non-lean MASLD: A comprehensive meta-analysis.Nso N, Mergen D, Ikram M, Macrinici V, Hussain K, Lee K, Ugwendum D, Trimingham M, Balasubramanian S, Sam R, Njei B. Curr Probl Cardiol. 2024 Jun; 2024 Apr 8. PMID: 38599554.
Approach to immunotherapy for HCC in the liver transplant population.Block PD, Strazzabosco M, Jaffe A. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 May 3. PMID: 38707244.
An explainable machine learning model for prediction of high-risk nonalcoholic steatohepatitis.Njei B, Osta E, Njei N, Al-Ajlouni YA, Lim JK. Sci Rep. 2024 Apr 13; 2024 Apr 13. PMID: 38615137.
Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring.Sun J, Esplugues E, Bort A, Cardelo MP, Ruz-Maldonado I, Fernández-Tussy P, Wong C, Wang H, Ojima I, Kaczocha M, Perry R, Suárez Y, Fernández-Hernando C. Nat Metab. 2024 Apr; 2024 Apr 25. PMID: 38664583.
Compartmentalized ocular lymphatic system mediates eye-brain immunity.Yin X, Zhang S, Lee JH, Dong H, Mourgkos G, Terwilliger G, Kraus A, Geraldo LH, Poulet M, Fischer S, Zhou T, Mohammed FS, Zhou J, Wang Y, Malloy S, Rohner N, Sharma L, Salinas I, Eichmann A, Thomas JL, Saltzman WM, Huttner A, Zeiss C, Ring A, Iwasaki A, Song E. Nature. 2024 Apr; 2024 Feb 28. PMID: 38418880.
Feasibility of an Interprofessional Inpatient Educational Intervention for Patients With Decompensated Cirrhosis.Haque LY, McDonough M, Deng Y, Ciarleglio MM, Liapakis A, Jakab S. Gastro Hep Adv. 2024; 2024 Mar 22. PMID: 39165423.
Mechanosensing regulates tissue repair program in macrophages.Meizlish ML, Kimura Y, Pope SD, Matta R, Kim C, Philip NH, Meyaard L, Gonzalez A, Medzhitov R. Sci Adv. 2024 Mar 15; 2024 Mar 13. PMID: 38478620.
Cell surface RNAs control neutrophil recruitment.Zhang N, Tang W, Torres L, Wang X, Ajaj Y, Zhu L, Luan Y, Zhou H, Wang Y, Zhang D, Kurbatov V, Khan SA, Kumar P, Hidalgo A, Wu D, Lu J. Cell. 2024 Feb 15; 2024 Jan 22. PMID: 38262409.
Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage.Ruz-Maldonado I, Gonzalez JT, Zhang H, Sun J, Bort A, Kabir I, Kibbey RG, Suárez Y, Greif DM, Fernández-Hernando C. Nat Commun. 2024 Feb 10; 2024 Feb 10. PMID: 38341404.
Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study.Mezzacappa C, Rossi R, Jaffe A, Taddei TH, Strazzabosco M. Cancer Epidemiol Biomarkers Prev. 2024 Feb 6. PMID: 38059831.
Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8(+) T-Cell Infiltration in Murine Hepatocellular Carcinoma.Shewarega A, Santana JG, Nam D, Berz A, Tefera J, Kahl V, Mishra SK, Coman D, Duncan J, Roberts SJ, Wetter A, Madoff DC, Chapiro J. Radiology. 2024 Feb. PMID: 38349244.
Modulation of canonical Wnt signaling regulates peribiliary mesenchymal identity during homeostasis and injury.Singh S, Budiman T, Redmond D, Gupta V. Hepatol Commun. 2024 Feb 1; 2024 Jan 22. PMID: 38251878.
Signaling between mammalian adiponectin and a mosquito adiponectin receptor reduces Plasmodium transmission.Chuang Y-M, Stone H, Abouneameh S, Tang X, Fikrig E. mBio. 2024 Jan 16; 2023 Dec 11. PMID: 38078744.
Author Correction: A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells.Li X, Jiang Q, Song G, Barkestani MN, Wang Q, Wang S, Fan M, Fang C, Jiang B, Johnson J, Geirsson A, Tellides G, Pober JS, Jane-Wit D. Nat Commun. 2023 Dec 18; 2023 Dec 18. PMID: 38110370.
HCC is associated with diabetes and longitudinal blood glucose control in a national cohort with cirrhosis.Mezzacappa C, Mahmud N, Serper M, John BV, Taddei TH, Kaplan DE. Hepatol Commun. 2023 Dec 1; 2023 Dec 7. PMID: 38055642.
Heterogeneous murine peribiliary glands orchestrate compartmentalized epithelial renewal.Singh S, Lian Q, Budiman T, Taketo MM, Simons BD, Gupta V. Dev Cell. 2023 Dec 4; 2023 Oct 30. PMID: 37909044.
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production.Song J, Lv H, Liu B, Hao M, Taylor HS, Zhang X, Li D, Huang Y. Mol Metab. 2023 Dec; 2023 Oct 28. PMID: 37898449.
LiverHccSeg: A publicly available multiphasic MRI dataset with liver and HCC tumor segmentations and inter-rater agreement analysis.Gross M, Arora S, Huber S, Kücükkaya AS, Onofrey JA. Data Brief. 2023 Dec; 2023 Oct 10. PMID: 37869619.
The Sympathetic Nervous System Promotes Hepatic Lymphangiogenesis, which Is Protective Against Liver Fibrosis.Tanaka M, Jeong J, Thomas C, Zhang X, Zhang P, Saruwatari J, Kondo R, McConnell MJ, Utsumi T, Iwakiri Y. Am J Pathol. 2023 Dec; 2023 Sep 4. PMID: 37673329.
Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma.Singh AK, Chaube B, Citrin KM, Fowler JW, Lee S, Catarino J, Knight J, Lowery S, Shree S, Boutagy N, Ruz-Maldonado I, Harry K, Shanabrough M, Ross TT, Malaker S, Suárez Y, Fernández-Hernando C, Grabinska K, Sessa WC. bioRxiv. 2023 Nov 15; 2023 Nov 15. PMID: 38014178.
HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosis.Huang Y, Liangpunsakul S, Rudraiah S, Ma J, Keshipeddy SK, Wright D, Costa A, Burgess D, Zhang Y, Huda N, Wang L, Yang Z. Hepatol Commun. 2023 Nov 1; 2023 Nov 6. PMID: 37930124.
An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver.Jeong J, Tanaka M, Yang Y, Arefyev N, DiRito J, Tietjen G, Zhang X, McConnell MJ, Utsumi T, Iwakiri Y. Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1; 2023 Aug 22. PMID: 37605828.
Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation.Arumugam S, Li B, Boodapati SLT, Nathanson MH, Sun B, Ouyang X, Mehal WZ. Hepatology. 2023 Nov 1; 2023 Apr 5. PMID: 37013923.
Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease.Du Y, de Jong IEM, Gupta K, Waisbourd-Zinman O, Har-Zahav A, Soroka CJ, Boyer JL, Llewellyn J, Liu C, Naji A, Polacheck WJ, Wells RG. Biofabrication. 2023 Oct 20; 2023 Oct 20. PMID: 37820623.
DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid.Oyaghire SN, Quijano E, Perera JDR, Mandl HK, Saltzman WM, Bahal R, Glazer PM. Cell Rep Phys Sci. 2023 Oct 18. PMID: 37920723.
Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4(+) T cells.Wang S, Song G, Barkestani MN, Tobiasova Z, Wang Q, Jiang Q, Lopez R, Adelekan-Kamara Y, Fan M, Pober JS, Tellides G, Jane-Wit D. Front Immunol. 2023; 2023 Oct 17. PMID: 37915586.
Serum Response Factor Reduces Gene Expression Noise and Confers Cell State Stability.Zhang J, Wu Q, Hu X, Wang Y, Lu J, Chakraborty R, Martin KA, Guo S. Stem Cells. 2023 Oct 8. PMID: 37386941.
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis.Mooring M, Yeung GA, Luukkonen P, Liu S, Akbar MW, Zhang GJ, Balogun O, Yu X, Mo R, Nejak-Bowen K, Poyurovsky MV, Booth CJ, Konnikova L, Shulman GI, Yimlamai D. Sci Transl Med. 2023 Sep 27; 2023 Sep 27. PMID: 37756381.
Protocol for enrichment, purification, and cytocentrifugation of mouse liver endothelial cells.Chowdhury S, Fried KD, Iwakiri Y, Brancale J, Vilarinho S. STAR Protoc. 2023 Sep 15; 2023 Jul 28. PMID: 37515764.
Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia.Li X, Lozovatsky L, Tommasini SM, Fretz J, Finberg KE. Blood Adv. 2023 Sep 12. PMID: 37417950.
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention.Qiu B, Lawan A, Xirouchaki CE, Yi JS, Robert M, Zhang L, Brown W, Fernández-Hernando C, Yang X, Tiganis T, Bennett AM. Nat Commun. 2023 Sep 5; 2023 Sep 5. PMID: 37669951.
Advancing diagnosis and management of liver disease in adults through exome sequencing.Zheng M, Hakim A, Konkwo C, Deaton AM, Ward LD, Silveira MG, Assis DN, Liapakis A, Jaffe A, Jiang ZG, Curry MP, Lai M, Cho MH, Dykas D, Bale A, Mistry PK, Vilarinho S. EBioMedicine. 2023 Sep; 2023 Aug 9. PMID: 37566928.
Hedgehog signalling in allograft vasculopathy: a new therapeutic target?Rowell J, Lau CI, Yánez DC, Zhang E, Crompton T. Trends Pharmacol Sci. 2023 Sep; 2023 Jun 7. PMID: 37296035.
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions.Kaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, Zhou J, Zheng Y, Charkoftaki G, Vasiliou V, Vatner DF, Mehal WZ, Yuval Kluger, Flavell RA. Cell. 2023 Aug 31; 2023 Aug 9. PMID: 37562401.
The evolving role of liver sinusoidal endothelial cells in liver health and disease.McConnell MJ, Kostallari E, Ibrahim SH, Iwakiri Y. Hepatology. 2023 Aug 1; 2023 Jan 3. PMID: 36626620.