AG-636 for the Treatment of Adults with Advanced Lymphoma: Initiation of a Phase 1 Clinical Study
Huntington S, Kallam A, Basile F, Ulanet D, Xu H, Yin F, Mobilia M, Cooper M, Shah B, Leonard J, von Keudell G, Gopal A. AG-636 for the Treatment of Adults with Advanced Lymphoma: Initiation of a Phase 1 Clinical Study. Blood 2019, 134: 1286. DOI: 10.1182/blood-2019-123420.Peer-Reviewed Original ResearchDose-limiting toxicityDiffuse large B-cellDose-escalation phaseAgios PharmaceuticalsAdvanced lymphomaHematologic malignanciesKaryopharm TherapeuticsSeattle GeneticsEscalation phaseT cellsEastern Cooperative Oncology Group performance statusADC therapeuticsActive central nervous system diseaseAdaptive Bayesian logistic regression modelChimeric antigen receptor T-cell therapyPrior stem cell transplantSerum total bilirubin levelPhase 1 clinical studyCentral nervous system diseaseDose-expansion phaseOptimal starting doseCycles of therapyOpen-label studyAbsolute neutrophil countAdvanced solid tumorsAnti-CD47 Antibody, CC-90002, in Combination with Rituximab in Subjects with Relapsed and/or Refractory Non-Hodgkin Lymphoma (R/R NHL)
Abrisqueta P, Sancho J, Cordoba R, Persky D, Andreadis C, Huntington S, Carpio C, Giles D, Wei X, Li Y, Zuraek M, Burgess M, Hege K, Martín A. Anti-CD47 Antibody, CC-90002, in Combination with Rituximab in Subjects with Relapsed and/or Refractory Non-Hodgkin Lymphoma (R/R NHL). Blood 2019, 134: 4089. DOI: 10.1182/blood-2019-125310.Peer-Reviewed Original ResearchIndependent data monitoring committeeCommon adverse eventsDose-limiting toxicityAdverse eventsCD47 antibodyData monitoring committeeSpeakers bureauR NHLFrequent grade 3/4 adverse eventsInternational Working Group response criteriaGrade 3/4 adverse eventsCelgene CorporationRefractory non-Hodgkin lymphomaBCR-ABL kinase domainAdvisory CommitteeMonitoring committeeF. Hoffmann-La Roche LtdDisease control ratePrior systemic therapyTreatment-related deathsDurable complete responseGrade 3 thrombocytopeniaInfusion-related reactionsModest clinical activityDose-limiting thrombocytopenia