2010
Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension
Rajkumar R, Konishi K, Richards TJ, Ishizawar DC, Wiechert AC, Kaminski N, Ahmad F. Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension. AJP Heart And Circulatory Physiology 2010, 298: h1235-h1248. PMID: 20081107, PMCID: PMC2853417, DOI: 10.1152/ajpheart.00254.2009.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionIdiopathic pulmonary fibrosisPathogenesis of PAHIdiopathic pulmonary arterial hypertensionPulmonary hypertensionArterial hypertensionRegulation of actinThrombospondin type 1 motif 9Pulmonary arteriolar remodelingSecondary pulmonary hypertensionCoagulation factor II receptorDistinct pathophysiological mechanismsLife-threatening conditionDistinct gene expression signaturesEstrogen receptor 1Nuclear receptor coactivator 2RNA expression profilesPurinergic receptor P2YGenomewide microarray analysisPlatelet factor 4RNA expression profilingHigh expression levelsOncogene homolog 1Gene expression signaturesProtein ubiquitination
2009
Gene Expression Profiles of Acute Exacerbations of Idiopathic Pulmonary Fibrosis
Konishi K, Gibson KF, Lindell KO, Richards TJ, Zhang Y, Dhir R, Bisceglia M, Gilbert S, Yousem SA, Song JW, Kim DS, Kaminski N. Gene Expression Profiles of Acute Exacerbations of Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2009, 180: 167-175. PMID: 19363140, PMCID: PMC2714820, DOI: 10.1164/rccm.200810-1596oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisStable idiopathic pulmonary fibrosisAcute exacerbationIPF lungsPulmonary fibrosisControl lungsPeripheral bloodReal-time quantitative reverse transcription polymerase chain reactionProtein levelsQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionApoptosis of epitheliumTranscription-polymerase chain reactionDUTP nick-end labeling assayNick-end labeling assayGlobal gene expression signaturesAgilent gene expression microarraysEnd-labeling assayDEFA1-3Gene expression signaturesInflammatory etiologyEpithelial injuryControl subjectsExacerbationLung
2005
Gene Expression Profiles Distinguish Idiopathic Pulmonary Fibrosis from Hypersensitivity Pneumonitis
Selman M, Pardo A, Barrera L, Estrada A, Watson SR, Wilson K, Aziz N, Kaminski N, Zlotnik A. Gene Expression Profiles Distinguish Idiopathic Pulmonary Fibrosis from Hypersensitivity Pneumonitis. American Journal Of Respiratory And Critical Care Medicine 2005, 173: 188-198. PMID: 16166619, PMCID: PMC2662988, DOI: 10.1164/rccm.200504-644oc.Peer-Reviewed Original ResearchConceptsGene expression signaturesExpression signaturesCustom oligonucleotide microarrayGene expression patternsOligonucleotide DNA microarrayStandard Affymetrix protocolGene clusterDNA microarraysExpression patternsGene expressionOligonucleotide microarraysComplementary ribonucleic acidTranscriptional signatureProbe setsCustom arrayT cell activationTissue remodelingNonspecific interstitial pneumoniaRibonucleic acidGenesMicroarrayInterstitial lung diseaseHypersensitivity pneumonitisPathogenic mechanismsExpressionPeripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors
Segman RH, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, Shalev AY. Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Molecular Psychiatry 2005, 10: 500-513. PMID: 15685253, DOI: 10.1038/sj.mp.4001636.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAdultFollow-Up StudiesGene Expression ProfilingGenetic MarkersHumansLeukocytes, MononuclearLife Change EventsMiddle AgedOligonucleotide Array Sequence AnalysisPredictive Value of TestsSeverity of Illness IndexStress Disorders, Post-TraumaticStress, PsychologicalSurvivorsConceptsGene expression signaturesPeripheral blood mononuclear cell gene expressionExpression signaturesTrauma survivorsPeripheral blood mononuclear cell gene expression profilesTime pointsDSM-IV diagnostic criteriaKey clinical featuresPost-traumatic stress disorder symptomsPost-traumatic stress disorderCell gene expression profilesClinical featuresOutcome predictorsEmergency roomPTSD symptom clustersDevelopment of PTSDPathogenetic implicationsDiagnostic criteriaChronic PTSDDiagnostic utilityEarly symptomsMental disordersNeuropsychiatric disordersSymptom clustersPTSD criteria
2004
Autoimmunity gene expression portrait: specific signature that intersects or differentiates between multiple sclerosis and systemic lupus erythematosus
MANDEL M, GUREVICH M, PAUZNER R, KAMINSKI N, ACHIRON A. Autoimmunity gene expression portrait: specific signature that intersects or differentiates between multiple sclerosis and systemic lupus erythematosus. Clinical & Experimental Immunology 2004, 138: 164-170. PMID: 15373920, PMCID: PMC1809188, DOI: 10.1111/j.1365-2249.2004.02587.x.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusPeripheral blood mononuclear cellsMultiple sclerosisHealthy subjectsAutoimmune signatureSLE patientsLupus erythematosusAutoimmune diseasesRelapsing-remitting MS patientsBlood mononuclear cellsMatrix metalloproteinase pathwayAdditional blood samplesDisease-specific signaturesDisease-associated signaturesTIMP1 gene expressionGene expression signaturesMS patientsMononuclear cellsSpecific therapyGene expression findingsMetalloproteinase pathwayNuclear autoantibodiesBlood samplesMMP activityPatients