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Further Babesiosis Biology, Pathogenicity Research Underway at Yale

Babesiosis, a tick-borne disease caused by Babesia parasites, is on the rise in the United States. The disease often presents with flu-like symptoms, but in some individuals, can progress to a more severe condition. Yet, despite the increasing significance of babesiosis in public health, there is limited understanding of the parasites’ biology, pathogenesis, and mechanism of virulence. Building on research initially reported in 2018 by a team of scientists led by Choukri Ben Mamoun, PhD, professor of medicine (infectious diseases), of microbial pathogenesis, and of pathology at Yale School of Medicine, the National Institutes of Health (NIH) awarded a $834,372 grant to further investigate Babesia biology and pathogenicity.

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  • Drinking Alcohol Increases the Risk of 6 Types of Cancer

    Excessive alcohol use is linked to over 200 different diseases, says Bubu Banini, MD, PhD, a member of the Yale Cancer Center and the associate director of the Clinical and Translational Core at the Yale Liver Center in New Haven, Connecticut.

    Source: Everyday Health
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  • Call for Abstracts: Yale Conference for Alcohol Research and Education 2024

    The Yale Conference for Alcohol Research and Education (YCARE) 2024 will take place on Saturday, October 19, 2024. The event is a dynamic day of learning, interaction, and collaboration focused on the theme of alcohol research. This year’s in-person event will feature podium talks, breakout sessions, a panel discussion, poster presentations, and more avenues to learn from and network with colleagues.

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  • Gut Microbiome Imbalance Promotes Liver Disease in Cystic Fibrosis

    About 30% of patients with cystic fibrosis report liver abnormalities and 10% of these patients go on to experience severe liver disease. Traditionally, cystic fibrosis-related liver disease was thought to be caused primarily by defective bile secretion due to the dysfunctional CFTR protein, which limited treatment options. Yale’s recent study led by Romina Fiorotto, PhD, and Mario Strazzabosco, MD, PhD, has identified a connection between the gut microbiome and the development of liver disease in cystic fibrosis patients.

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  • Unique Immune Profile Identified in Fibrotic Hypersensitivity Pneumonitis

    Fibrotic hypersensitivity pneumonitis is a chronic and progressive interstitial lung disease, caused by an immune response to inhaled foreign antigens or allergens. Researchers from Yale’s Section of Pulmonary, Critical Care and Sleep Medicine have used single-cell sequencing technology to provide the first high-resolution atlas of this disease, revealing a previously unrecognized immune signature. Their findings were recently published in the American Journal of Respiratory and Critical Care Medicine.

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  • Making Antifungal Medications More Effective

    A new study led by Yale researchers uncovers a new cellular process that links the metabolism of vitamin B5 to the ability of fungi to detoxify drugs. These findings represent a significant leap in our understanding of fungal resistance mechanisms and herald new treatment possibilities for combating resilient fungal strains, with far-reaching implications for patients worldwide.

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  • 11 Yale Projects Receive Awards from the Colton Center for Autoimmunity

    The Colton Center for Autoimmunity at Yale is pleased to announce the eleven 2024 Yale projects selected for their promising research in autoimmunity and allergic diseases. In addition to grant funding, Colton Center awardees receive mentorship, access to industry expertise, and feedback on their potential commercialization.

    Source: Yale Ventures
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