2023
Post-diagnosis weight trajectories and mortality among women with breast cancer
Puklin L, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, Winer E, Lustberg M, Spiegelman D, Sharifi M, Irwin M, Ferrucci L. Post-diagnosis weight trajectories and mortality among women with breast cancer. Npj Breast Cancer 2023, 9: 98. PMID: 38042922, PMCID: PMC10693588, DOI: 10.1038/s41523-023-00603-5.Peer-Reviewed Original ResearchBody mass indexBreast cancer diagnosisWeight changeCause mortalityClinical characteristicsWeight gainWeight lossBreast cancerWeight trajectoriesPost-diagnosis weight changeBreast cancer-specific mortalityCox proportional hazards modelModern treatment eraCancer-specific mortalityCancer diagnosisModerate weight lossModerate weight gainProportional hazards modelAdverse health outcomesElectronic health recordsTreatment eraBaseline characteristicsTumor RegistryMass indexWeight management
2022
Cardiometabolic risk factors, physical activity, and postmenopausal breast cancer mortality: results from the Women’s Health Initiative
Dieli-Conwright CM, Nelson RA, Simon MS, Irwin ML, Neuhouser ML, Reding KW, Crane TE, Manson JE, Nassir R, Shadyab AH, LaMonte M, Qi L, Thomson CA, Kroenke CH, Pan K, Chlebowski RT, Mortimer J. Cardiometabolic risk factors, physical activity, and postmenopausal breast cancer mortality: results from the Women’s Health Initiative. BMC Women's Health 2022, 22: 32. PMID: 35120497, PMCID: PMC8817588, DOI: 10.1186/s12905-022-01614-3.Peer-Reviewed Original ResearchConceptsBreast cancer-specific mortalityCancer-specific mortalityWomen's Health Initiative participantsEarly-stage breast cancerCardiometabolic risk factorsBreast cancer mortalityPhysical activity levelsRisk factor numberPhysical activityBreast cancerRisk factorsCancer mortalityHigher breast cancer-specific mortalityLower breast cancer-specific mortalityInitiative participantsHealth initiativesNational Death Index queryProportional hazards regression modelsHigher physical activity levelsCancer diagnosisMetabolic syndrome componentsBaseline physical activityHigh waist circumferenceMedical record reviewCause mortality risk
2021
Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers
Cheng E, Soulos PR, Irwin ML, Feliciano E, Presley CJ, Fuchs CS, Meyerhardt JA, Gross CP. Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers. JAMA Network Open 2021, 4: e2139593. PMID: 34919133, PMCID: PMC8683967, DOI: 10.1001/jamanetworkopen.2021.39593.Peer-Reviewed Original ResearchConceptsCancer-specific mortalityNeighborhood socioeconomic statusIndividual-level socioeconomic statusIndividual socioeconomic statusColorectal cancerOverall mortalitySocioeconomic statusCohort studyHazard ratioDual eligibilityCancer patientsCommon cancerLung cancerProstate cancerSocioeconomic disadvantageHigh riskEnd Results-Medicare databaseMedicare-Medicaid dual eligibilityPopulation-based cohort studyCox proportional hazards regressionSuboptimal cancer careColorectal cancer patientsBreast cancer patientsProportional hazards regressionNon-Hispanic white individualsPrediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer
Wang T, Townsend MK, Eliassen AH, Terry KL, Song M, Irwin ML, Tworoger SS. Prediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer. International Journal Of Cancer 2021, 149: 1067-1075. PMID: 33963766, PMCID: PMC8282739, DOI: 10.1002/ijc.33676.Peer-Reviewed Original ResearchConceptsOvarian cancer-specific mortalityCancer-specific mortalityNurses' Health StudyPhysical activityHazard ratioOvarian cancerHealth StudyWeek 1MET-hours/weekLow-grade serous tumorsLeisure-time physical activityPostdiagnosis physical activityRisk of deathEpithelial ovarian cancerOvarian cancer survivalConfidence intervalsTime physical activityOvarian cancer diagnosisBetter prognosisSerous tumorsCancer survivalInverse associationLarge cohortDiagnosisCancer diagnosis
2015
Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis
Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML. Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis. Journal Of The National Cancer Institute 2015, 107: djv275. PMID: 26424778, PMCID: PMC4715249, DOI: 10.1093/jnci/djv275.Peer-Reviewed Original ResearchConceptsBody mass indexBreast cancer-specific mortalityCancer-specific mortalityCause mortalityWeight gainBreast cancer diagnosisBreast cancerStage I-IIIC breast cancerSystematic reviewPrediagnosis body mass indexWomen age 18 yearsPostdiagnosis weight gainCancer diagnosisCause mortality ratesBreast cancer mortalityAge 18 yearsWeb of ScienceCohort studyRecurrence outcomesMass indexCancer mortalityClinical trialsHigh riskMortality rateBody weight
2011
Physical Activity and Survival in Postmenopausal Women with Breast Cancer: Results from the Women's Health Initiative
Irwin ML, McTiernan A, Manson JE, Thomson CA, Sternfeld B, Stefanick ML, Wactawski-Wende J, Craft L, Lane D, Martin LW, Chlebowski R. Physical Activity and Survival in Postmenopausal Women with Breast Cancer: Results from the Women's Health Initiative. Cancer Prevention Research 2011, 4: 522-529. PMID: 21464032, PMCID: PMC3123895, DOI: 10.1158/1940-6207.capr-10-0295.Peer-Reviewed Original ResearchConceptsCause mortalityPostmenopausal womenPhysical activityBreast cancerMore MetHealth initiativesLower breast cancer mortalityBreast cancer-specific mortalityWomen's Health Initiative studyActive breast cancer survivorsCancer-specific mortalityInvasive breast cancerLow physical activityBreast cancer survivorsMultivariable adjusted analysesWomen's Health InitiativeBreast cancer mortalityAdjusted analysisCancer survivorsCancer mortalityInactive womenInitiative studyMortalityCancerDiagnosis