2024
Association between diet quality and ovarian cancer risk and survival
Cao A, Esserman D, Cartmel B, Irwin M, Ferrucci L. Association between diet quality and ovarian cancer risk and survival. Journal Of The National Cancer Institute 2024, 116: 1095-1104. PMID: 38400738, PMCID: PMC11223874, DOI: 10.1093/jnci/djae040.Peer-Reviewed Original ResearchOvarian cancer riskAll-cause mortalityAssociated with lower all-cause mortalityDiet qualityCancer riskOvarian cancer diagnosisAssociated with ovarian cancer riskPre-diagnosisProspective NIH-AARP DietHealthy Eating Index-2015Cancer diagnosisNIH-AARP DietStop Hypertension scoreCancer registry dataEpithelial ovarian cancerMediterranean diet scoreFood frequency questionnaireCox proportional hazards regressionOvarian cancerProportional hazards regressionHEI-2015Health StudyHypertension scoreDiet scoreFrequency questionnaire
2023
Structural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review.
Pichardo M, Ferrucci L, Molina Y, Esserman D, Irwin M. Structural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1498-1507. PMID: 37650844, PMCID: PMC10872641, DOI: 10.1158/1055-9965.epi-22-1147.Peer-Reviewed Original ResearchConceptsHispanic/Latino adultsObesity-related cancersLifestyle behaviorsLatino adultsLifestyle guidelinesCancer preventionPoor lifestyle behaviorsU.S. Hispanic/Latino adultsHealthful lifestyle behaviorsCause of deathHealthy lifestyle choicesChronic diseasesCardiovascular diseaseCommon causeCancer riskNarrative reviewBlack adultsDisproportionate burdenObesityCancerAdultsLifestyle choicesDiseasePreventionDeath
2022
A competing risk analysis of adherence to the American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and obesity‐related cancer risk in Hispanic/Latino adults in the NIH‐AARP Diet and Health Study
Pichardo MS, Irwin ML, Esserman D, Molina Y, Ferrucci LM. A competing risk analysis of adherence to the American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and obesity‐related cancer risk in Hispanic/Latino adults in the NIH‐AARP Diet and Health Study. International Journal Of Cancer 2022, 151: 1902-1912. PMID: 35802472, PMCID: PMC9588580, DOI: 10.1002/ijc.34200.Peer-Reviewed Original ResearchConceptsHispanic/Latino adultsObesity-related cancersUS Hispanic/Latino adultsAmerican Cancer Society guidelinesNIH-AARP DietHealthy lifestyle behaviorsGuideline adherenceLatino adultsSociety guidelinesLifestyle behaviorsCancer preventionPhysical activityCancer riskHealth StudyObesity-related cancer riskPublic health effortsHypothesized inverse associationMagnitude of riskAdherence categoriesInverse associationCancer incidenceACS guidelinesHigh adherenceCumulative riskHealth efforts
2020
Energetics
Ferrucci L, Irwin M. Energetics. 2020, 303-320. DOI: 10.1007/978-3-030-42011-6_15.Peer-Reviewed Original ResearchWeight loss interventionCancer riskLoss interventionCancer outcomesRisk factorsReduced cancer riskIndependent risk factorEnergy balance interventionsDifferent cancer sitesDiet interventionPhysical inactivityDifferent cancer typesSurrogate markerCancer sitesBalance interventionsPhysical activityNew therapiesPoor dietObesityVaried age groupsAge groupsCancer typesCancer developmentMortalityWeight lossTransdisciplinary Research in Energetics and Cancer early career investigator training program: first year results
Irwin ML, Lowry D, Neuhouser ML, Ligibel J, Schmitz K, Patterson RE, Colditz G, Li F, Nebeling L. Transdisciplinary Research in Energetics and Cancer early career investigator training program: first year results. Translational Behavioral Medicine 2020, 11: 549-562. PMID: 32065834, PMCID: PMC7963289, DOI: 10.1093/tbm/ibaa009.Peer-Reviewed Original ResearchConceptsYear of mentorshipYear 1 participantsEarly career investigatorsCancer burdenCancer riskHealth of populationsMentorship periodTraining programProgram satisfactionGroup sessionsCancer researchSmall group sessionsYear resultsFirst year resultsRiskEnergy imbalanceProgram impactFifth yearCourseInvestigatorsSessionsFellowsYearsCancerMortality
2016
Effects of Physical Activity on DNA Methylation and Associations with Breast Cancer
Yu H, Irwin M. Effects of Physical Activity on DNA Methylation and Associations with Breast Cancer. Energy Balance And Cancer 2016, 11: 251-264. DOI: 10.1007/978-3-319-41610-6_11.Peer-Reviewed Original ResearchDNA methylationTumor suppressor genePhysical activityEpigenetic regulationSuppressor geneCancer riskGenome-wide methylationBetter patient survivalBreast cancer patientsPro-inflammatory cytokinesBreast cancer riskSex steroid hormonesLower cancer riskMitogenic growth factorsEntire genomeMolecular mechanismsInsulin resistancePatient survivalCancer patientsMethylationMore profound impactsCancer preventionBreast cancerDisease outcomeHealthy individuals
2009
Randomized Controlled Trial of Aerobic Exercise on Insulin and Insulin-like Growth Factors in Breast Cancer Survivors: The Yale Exercise and Survivorship Study
Irwin ML, Varma K, Alvarez-Reeves M, Cadmus L, Wiley A, Chung GG, DiPietro L, Mayne ST, Yu H. Randomized Controlled Trial of Aerobic Exercise on Insulin and Insulin-like Growth Factors in Breast Cancer Survivors: The Yale Exercise and Survivorship Study. Cancer Epidemiology Biomarkers & Prevention 2009, 18: 306-313. PMID: 19124513, PMCID: PMC2841479, DOI: 10.1158/1055-9965.epi-08-0531.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsPostmenopausal breast cancer survivorsModerate-intensity aerobic exerciseUsual care groupBreast cancer riskAerobic exerciseIGFBP-3Cancer survivorsUsual careCare groupCancer riskYale-New Haven Hospital Tumor RegistryCurrent physical activity levelsInsulin-like growth factorHospital tumor registryUsual care participantsAerobic exercise interventionExercise-induced decreasePhysical activity levelsInsulin-like growthExercise groupExercise interventionControlled TrialsTumor RegistryBrisk walking