2024
Utility of the PICOTS framework to assess clinical trial disruptions: monitoring the impact of COVID-19 in the Pain Management Collaboratory
Peduzzi P, Brandt C, Dearth C, Dziura J, Farrokhi S, George S, Kyriakides T, Long C, Mascha E, Patterson C, Rhon D, Kerns R. Utility of the PICOTS framework to assess clinical trial disruptions: monitoring the impact of COVID-19 in the Pain Management Collaboratory. Pain Medicine 2024, 25: s34-s40. PMID: 39514876, PMCID: PMC11548861, DOI: 10.1093/pm/pnae078.Peer-Reviewed Original ResearchConceptsPain Management CollaboratoryPICOTS frameworkIndividual-level randomizationPain management researchPragmatic clinical trialsIntervention fidelityCare deliveryStepped-wedgeSpecialty careClinical partnersCOVID-19 experienceIn-personPain managementOutcome assessmentStudy designCOVID-19Nonpharmacologic approachesImpact of COVID-19PICOTExperimental interventionLead investigatorsTrial designDesign of clinical trialsAffective deliveryPain
2022
The Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers
Webb SJ, Naples AJ, Levin AR, Hellemann G, Borland H, Benton J, Carlos C, McAllister T, Santhosh M, Seow H, Atyabi A, Bernier R, Chawarska K, Dawson G, Dziura J, Faja S, Jeste S, Murias M, Nelson CA, Sabatos-DeVito M, Senturk D, Shic F, Sugar CA, McPartland JC. The Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers. American Journal Of Psychiatry 2022, 180: 41-49. PMID: 36000217, PMCID: PMC10027395, DOI: 10.1176/appi.ajp.21050485.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderAutistic DisorderBiomarkersClinical Trials as TopicElectroencephalographyEvoked Potentials, VisualHumansConceptsBiological motion perceptionAutism spectrum disorderResting-state activityMotion perceptionEEG biomarkersGroup discriminationPsychometric propertiesBasic psychometric propertiesASD groupASD diagnosisNeural responsesSpectrum disorderAlpha powerN170Naturalistic studyPerceptionMixed resultsTask latencyVEP amplitudeContext of useLimited attentionInconsistent resultsAcquisition rateDiscriminationBatteries
2020
Quality and Publication of Emergency Medicine Trials Registered in ClinicalTrials.gov
Calvocoressi L, Reynolds J, Johnson B, Warzoha MM, Carroll M, Vaca FE, Post L, Dziura J. Quality and Publication of Emergency Medicine Trials Registered in ClinicalTrials.gov. Western Journal Of Emergency Medicine 2020, 21: 295-303. PMID: 32191186, PMCID: PMC7081876, DOI: 10.5811/westjem.2019.12.44096.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicEmergency MedicineHumansNational Institutes of Health (U.S.)PublicationsResearch DesignUnited StatesConceptsClinical trialsEM trialsKaplan-Meier curvesLog-rank testNational clinical trialClinical trial researchChi-square testEM studiesTrial qualityInterventional trialsPeer-reviewed journalsMedicine trialsNeurological conditionsLarger sample sizeTrial researchStudy characteristicsStudy periodTrialsNational InstituteSubspecialty areasBlindingPeriodic assessmentDescriptive statisticsHigher proportionIndustry funding
2013
Strategies for dealing with missing data in clinical trials: from design to analysis.
Dziura JD, Post LA, Zhao Q, Fu Z, Peduzzi P. Strategies for dealing with missing data in clinical trials: from design to analysis. The Yale Journal Of Biology And Medicine 2013, 86: 343-58. PMID: 24058309, PMCID: PMC3767219.Peer-Reviewed Original Research