2021
Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study.
Mauras N, Buckingham B, White NH, Tsalikian E, Weinzimer SA, Jo B, Cato A, Fox LA, Aye T, Arbelaez AM, Hershey T, Tansey M, Tamborlane W, Foland-Ross LC, Shen H, Englert K, Mazaika P, Marzelli M, Reiss AL. Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study. Diabetes Care 2021, 44: 983-992. PMID: 33568403, PMCID: PMC7985430, DOI: 10.2337/dc20-2125.Peer-Reviewed Original ResearchConceptsType 1 diabetesBrain volumeControl subjectsTotal brain volume differencesEarly-onset type 1 diabetesAge-matched control subjectsIntelligence quotientCognitive scoresWhite matter volumeBrain volume differencesContinuous glucose monitoringDiabetes groupFull-scale intelligence quotientDiabetes complicationsDiabetes controlTotal brainVerbal intelligence quotientDiabetesMatter volumeSensor glucoseCognitive testingGlucose monitoringMixed-effects modelsBrainGroup differences
2018
Impact of Early Diabetic Ketoacidosis on the Developing Brain
Aye T, Mazaika PK, Mauras N, Marzelli MJ, Shen H, Hershey T, Cato A, Weinzimer SA, White NH, Tsalikian E, Jo B, Reiss AL, Group D, Tsalikian E, Tansey M, Coffey J, Cabbage J, Salamati S, Mauras N, Fox L, Cato A, Englert K, Sikes K, Buckingham B, Wilson D, Aye T, Caswell K, Ambers E, Weinzimer S, Tamborlane W, Steffen A, Weyman K, Zgorski M, Ambrosino J, White N, Arbelaez A, Levandoski L, Starnes A, Hershey T, Reiss A, Barnea-Goraly N, Marzelli M, Mazaika P, Peng D, Beck R, Kollman C, Ruedy K, Winer K, Sperling M, Becker D, Cleary P, Greenbaum C, Moran A. Impact of Early Diabetic Ketoacidosis on the Developing Brain. Diabetes Care 2018, 42: dc181405. PMID: 30573652, PMCID: PMC6385695, DOI: 10.2337/dc18-1405.Peer-Reviewed Original Research
2016
Altered Integration of Structural Covariance Networks in Young Children With Type 1 Diabetes
Hosseini SM, Mazaika P, Mauras N, Buckingham B, Weinzimer SA, Tsalikian E, White NH, Reiss AL, Network F. Altered Integration of Structural Covariance Networks in Young Children With Type 1 Diabetes. Human Brain Mapping 2016, 37: 4034-4046. PMID: 27339089, PMCID: PMC5053865, DOI: 10.1002/hbm.23293.Peer-Reviewed Original ResearchConceptsEarly-onset T1DStructural covariance networksYoung childrenNeurocognitive deficitsType 1 diabetes mellitusCovariance networksBrain networksFrequent chronic diseasesHum Brain MappRegional gray matterGlycemic controlDiabetes mellitusGlucose dysregulationNeural insultsHealthy controlsLarge-scale brain networksChronic diseasesBulk of evidenceNeuroanatomical changesT1DWhite matterGray matterBrain developmentGraph theoretical analysisT1D.Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes
Saggar M, Tsalikian E, Mauras N, Mazaika P, White NH, Weinzimer S, Buckingham B, Hershey T, Reiss AL. Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes. Diabetes 2016, 66: 754-762. PMID: 27702833, PMCID: PMC5319714, DOI: 10.2337/db16-0414.Peer-Reviewed Original ResearchConceptsControl subjectsIntrinsic connectivityAge-matched control subjectsYoung childrenBrain intrinsic connectivityResting-state functional MRI dataType 1 diabetesSeed-based analysisCognitive functioningBlood glucoseSustained dysregulationOverall group differencesLarge multisite studyT1DYounger ageFunctional MRI dataCognitive deficitsType 1Cognitive functionObserved positive associationDiabetesMultisite studyCompensatory roleGroup differencesBrain
2015
Variations in Brain Volume and Growth in Young Children With Type 1 Diabetes
Mazaika PK, Weinzimer SA, Mauras N, Buckingham B, White NH, Tsalikian E, Hershey T, Cato A, Aye T, Fox L, Wilson DM, Tansey MJ, Tamborlane W, Peng D, Raman M, Marzelli M, Reiss AL. Variations in Brain Volume and Growth in Young Children With Type 1 Diabetes. Diabetes 2015, 65: 476-485. PMID: 26512024, PMCID: PMC4747456, DOI: 10.2337/db15-1242.Peer-Reviewed Original ResearchConceptsEarly-onset type 1 diabetesType 1 diabetesBlood glucose levelsWhite matter volumeGlucose levelsMatter volumeTime pointsBrain volumeAge-matched control subjectsCortical gray matter volumeMeasures of hyperglycemiaMean HbA1c levelCurrent treatment guidelinesManagement of diabetesRapid brain maturationGray matter volumeTime of scanCortical surface areaHbA1c levelsTreatment guidelinesControl subjectsGlycemic variationsLongitudinal time pointsBrain maturationDiabetes
2014
Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children With Type 1 Diabetes: Association With Hyperglycemia
Mauras N, Mazaika P, Buckingham B, Weinzimer S, White NH, Tsalikian E, Hershey T, Cato A, Cheng P, Kollman C, Beck RW, Ruedy K, Aye T, Fox L, Arbelaez AM, Wilson D, Tansey M, Tamborlane W, Peng D, Marzelli M, Winer KK, Reiss AL. Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children With Type 1 Diabetes: Association With Hyperglycemia. Diabetes 2014, 64: 1770-1779. PMID: 25488901, PMCID: PMC4407847, DOI: 10.2337/db14-1445.Peer-Reviewed Original ResearchConceptsWhite matter growthControl subjectsAge-matched control subjectsType 1 diabetesHigh-resolution structural MRIWhite matter areasWhite matter volumeYoung childrenContinuous glucose monitoringGray matter regionsNondiabetic childrenChronic hyperglycemiaExecutive function scoresFunction scoresGlucose variabilityMatter volumeChildren ages 4Comprehensive neurocognitive testsBrain regionsLongitudinal assessmentType 1Structural MRIHyperglycemiaDiabetesMatter regionsSkin and Adhesive Issues With Continuous Glucose Monitors
Englert K, Ruedy K, Coffey J, Caswell K, Steffen A, Levandoski L, Tsalikian E, Tansey M, Coffey J, Cabbage J, Salamati S, Mauras N, Fox L, Englert K, Permuy J, Sikes K, Buckingham B, Wilson D, Clinton P, Caswell K, Weinzimer S, Tamborlane W, Sherr J, Steffen A, Weyman K, Zgorski M, Tichy E, White N, Arbelaez A, Levandoski L, Starnes A, Beck R, Ruedy K, Kollman C, Xing D, Hall C, Stevens B, Grave G, Winer K, Leschek E, Becker D, Cleary P, Greenbaum C, Moran A, Steffes M, Bucksa J, Nowicki M, Makky V. Skin and Adhesive Issues With Continuous Glucose Monitors. Journal Of Diabetes Science And Technology 2014, 8: 745-751. PMID: 24876416, PMCID: PMC4764227, DOI: 10.1177/1932296814529893.Peer-Reviewed Original ResearchConceptsContinuous glucose monitoringSkin irritationLimited body surface areaYoung childrenBody surface areaType 1 diabetesDuration of useCGM devicesReduced skin irritationSupplemental productsContinuous glucose monitorStudy groupPhysical activityImproved adherenceStudy coordinatorsCGM useSmall childrenGlucose monitoringIrritationChildrenGlucose monitorSensor wearDaily useAlterations in White Matter Structure in Young Children With Type 1 Diabetes
Barnea-Goraly N, Raman M, Mazaika P, Marzelli M, Hershey T, Weinzimer SA, Aye T, Buckingham B, Mauras N, White NH, Fox LA, Tansey M, Beck RW, Ruedy KJ, Kollman C, Cheng P, Reiss AL, . Alterations in White Matter Structure in Young Children With Type 1 Diabetes. Diabetes Care 2014, 37: 332-340. PMID: 24319123, PMCID: PMC3898758, DOI: 10.2337/dc13-1388.Peer-Reviewed Original Research
2013
Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
Marzelli MJ, Mazaika PK, Barnea-Goraly N, Hershey T, Tsalikian E, Tamborlane W, Mauras N, White NH, Buckingham B, Beck RW, Ruedy KJ, Kollman C, Cheng P, Reiss AL, Network F. Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes. Diabetes 2013, 63: 343-353. PMID: 24170697, PMCID: PMC3868050, DOI: 10.2337/db13-0179.Peer-Reviewed Original ResearchConceptsGray matter volumeT1D groupControl subjectsWhole brain volumetric analysisAge-matched control subjectsEarly-onset T1DNeuroanatomical correlatesType 1 diabetesRegional brain volumesYoung childrenVoxel-based morphometryMedial prefrontal cortexGlycemic dysregulationGlycemic exposureTemporal-occipital regionsTemporal pole regionsStructural magnetic resonance imagesHyperglycemic exposureMatter volumeBrain volumeType 1Cerebellar regionsPrefrontal cortexBrain structuresMagnetic resonance images
2009
Blunted Counterregulatory Hormone Responses to Hypoglycemia in Young Children and Adolescents With Well-Controlled Type 1 Diabetes
Tsalikian E, Tamborlane W, Xing D, Becker D, Mauras N, Fiallo-Scharer R, Buckingham B, Weinzimer S, Steffes M, Singh R, Beck R, Ruedy K, Kollman C. Blunted Counterregulatory Hormone Responses to Hypoglycemia in Young Children and Adolescents With Well-Controlled Type 1 Diabetes. Diabetes Care 2009, 32: 1954-1959. PMID: 19675205, PMCID: PMC2768200, DOI: 10.2337/dc08-2298.Peer-Reviewed Original ResearchConceptsType 1 diabetesPlasma glucose concentrationEpinephrine responsePlasma glucoseYoung childrenInsulin pump-treated patientsHypoglycemia-associated autonomic failurePump-treated patientsLower plasma glucose concentrationsIntensive insulin therapySymptoms of hypoglycemiaInsulin infusion protocolCounterregulatory hormone concentrationsGlucose concentrationAbsence of signsClosed-loop insulin delivery systemsContinuous glucose monitoringAcute complicationsAutonomic failureCounterregulatory hormonesSympathoadrenal responseInsulin therapyPatient ageNondiabetic adolescentsSymptom scores
2008
Prolonged use of continuous glucose monitors in children with type 1 diabetes on continuous subcutaneous insulin infusion or intensive multiple‐daily injection therapy
Weinzimer S, Xing D, Tansey M, Fiallo-Scharer R, Mauras N, Wysocki T, Beck R, Tamborlane W, Ruedy K. Prolonged use of continuous glucose monitors in children with type 1 diabetes on continuous subcutaneous insulin infusion or intensive multiple‐daily injection therapy. Pediatric Diabetes 2008, 10: 91-96. PMID: 19175899, DOI: 10.1111/j.1399-5448.2008.00476.x.Peer-Reviewed Original ResearchConceptsContinuous glucose monitorType 1 diabetesMDI usersCSII usersContinuous subcutaneous insulin infusionMultiple daily injection therapySubcutaneous insulin infusionTreatment of childrenGlucose monitorContinuous glucose monitoring systemLong-term useInjection therapyClinical factorsGlucose monitoring systemInsulin infusionAmbulatory settingWeek 22Week 1Pilot studyWkT1DDiabetesChildrenSatisfaction surveyDaily use
2007
Continuous Glucose Monitoring in Children with Type 1 Diabetes
Buckingham B, Beck R, Tamborlane W, Xing D, Kollman C, Fiallo-Scharer R, Mauras N, Ruedy K, Tansey M, Weinzimer S, Wysocki T. Continuous Glucose Monitoring in Children with Type 1 Diabetes. The Journal Of Pediatrics 2007, 151: 388-393.e2. PMID: 17889075, PMCID: PMC2045068, DOI: 10.1016/j.jpeds.2007.03.047.Peer-Reviewed Original ResearchConceptsContinuous glucose monitoringContinuous glucose monitorReal-time continuous glucose monitoringGlucose monitoringMean hemoglobin A1cSevere skin reactionsType 1 diabetesGlucose monitorContinuous glucose monitoring systemInsulin pump usersDaily useGlycemic controlHemoglobin A1cDaily treatmentGlucose monitoring systemSkin reactionsWeek 9Glucose valuesBaseline levelsType 1WeeksPump usersT1DHigh satisfactionChildren
2001
Acarbose treatment of postprandial hypoglycemia in children after Nissen fundoplication
Ng D, Ferry R, Kelly A, Weinzimer S, Stanley C, Katz L. Acarbose treatment of postprandial hypoglycemia in children after Nissen fundoplication. The Journal Of Pediatrics 2001, 139: 877-879. PMID: 11743518, DOI: 10.1067/mpd.2001.119169.Peer-Reviewed Original ResearchGraves' disease in patients with 22q11.2 deletion
Kawame H, Adachi M, Tachibana K, Kurosawa K, Ito F, Gleason M, Weinzimer S, Levitt-Katz L, Sullivan K, McDonald-McGinn D. Graves' disease in patients with 22q11.2 deletion. The Journal Of Pediatrics 2001, 139: 892-895. PMID: 11743521, DOI: 10.1067/mpd.2001.119448.Peer-Reviewed Original ResearchConceptsGraves' diseaseThyroid-stimulating hormone levelsSymptoms of hyperthyroidismMale patientsSerum levelsClinical presentationFemale patientsClinical spectrumFemale infantAge 27 monthsHormone levelsPatientsThyroid hormonesDiseaseDeletion syndromeHyperthyroidismSeizuresInfantsSyndromeSymptomsHormoneMonths
1998
Growth Hormone Deficiency in Patients With a 22q11.2 Deletion: Expanding the Phenotype
Weinzimer S, McDonald-McGinn D, Driscoll D, Emanuel B, Zackai E, Moshang T. Growth Hormone Deficiency in Patients With a 22q11.2 Deletion: Expanding the Phenotype. Pediatrics 1998, 101: 929-932. PMID: 9565428, DOI: 10.1542/peds.101.5.929.Peer-Reviewed Original ResearchMeSH KeywordsChildChild, PreschoolChromosomes, Human, Pair 22FemaleGene DeletionGrowth DisordersHuman Growth HormoneHumansMalePhenotypeConceptsGrowth hormone deficiencyShort statureCardiac anomaliesHormone deficiencyVelocardiofacial syndromeLike growth factor I axisProvocative growth hormone testingT-cell abnormalitiesGrowth hormone therapyGrowth hormone testingFinal height predictionConotruncal cardiac anomaliesThird of childrenConotruncal anomaly face syndromeMild facial dysmorphiaHormone therapyPituitary anatomyHormone testingPituitary abnormalitiesI axisThymic aplasiaCell abnormalitiesGeneral populationPatientsDiGeorge sequence
1997
A syndrome of congenital hyperinsulinism and hyperammonemia
Weinzimer S, Stanley C, Berry G, Yudkoff M, Tuchman M, Thornton P. A syndrome of congenital hyperinsulinism and hyperammonemia. The Journal Of Pediatrics 1997, 130: 661-664. PMID: 9108870, DOI: 10.1016/s0022-3476(97)70256-7.Peer-Reviewed Original ResearchConceptsCongenital hyperinsulinismLarge glycemic responseAcid levelsFree fatty acid levelsUrea cycle enzyme defectsElevated insulin levelsDiagnosis of hyperinsulinismUrinary amino acidsOrotic acid levelsUrinary orotic acid levelsAdministration of glucagonFatty acid levelsAutosomal recessive variantInsulin levelsBenzoate therapyProtein restrictionInsulin secretionUnusual syndromeUrinary organic acidsHyperammonemic disordersGlycemic responseHyperinsulinismPatientsProtein feedingRecessive variantsThe 22q11.2 Deletion: Screening, Diagnostic Workup, and Outcome of Results; Report on 181 Patients
McDonald-McGinn DM, LaRossa D, Goldmuntz E, Sullivan K, Eicher P, Gerdes M, Moss E, Wang P, Solot C, Schultz P, Lynch D, Bingham P, Keenan G, Weinzimer S, Ming JE, Driscoll D, Clark BJ, Markowitz R, Cohen A, Moshang T, Pasquariello P, Randall P, Emanuel BS, Zackai EH. The 22q11.2 Deletion: Screening, Diagnostic Workup, and Outcome of Results; Report on 181 Patients. Genetic Testing And Molecular Biomarkers 1997, 1: 99-108. PMID: 10464633, DOI: 10.1089/gte.1997.1.99.Peer-Reviewed Original ResearchConceptsCayler cardiofacial syndromeCohort of patientsMajority of patientsConotruncal cardiac anomaliesConotruncal anomaly face syndromeSubmicroscopic deletionCardiac anomaliesDiagnostic workupCardiofacial syndromeOpitz G/BBB syndromePatientsSyndromeDiGeorge syndromeFace syndromeVelocardiofacial syndromeVariable phenotypeBBB syndromeChromosome 22q11.2Outcome of resultsDeletionCohortSubspecialistsWorkupClinicians