2012
Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens
Jog NR, Frisoni L, Shi Q, Monestier M, Hernandez S, Craft J, Prak ET, Caricchio R. Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens. Arthritis & Rheumatism 2012, 64: 1247-1256. PMID: 22127758, PMCID: PMC3292632, DOI: 10.1002/art.33448.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoimmune responseMouse modelApoptotic cellsNuclear autoantigensDNA antibody titersLupus-prone miceAbsence of CADMaintenance of toleranceAutoreactive B cellsAnti-DNA antibodiesApoptotic modificationsLupus developmentGeneration of autoantigensAntinuclear antibodiesLupus erythematosusAntibody titersAutoimmune diseasesActive caspase-3Apoptotic bodiesB cellsMiceAutoantigensCAD deficiencyCaspase-3
2009
Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation
Marks BR, Nowyhed HN, Choi JY, Poholek AC, Odegard JM, Flavell RA, Craft J. Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation. Nature Immunology 2009, 10: 1125-1132. PMID: 19734905, PMCID: PMC2751862, DOI: 10.1038/ni.1783.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantigensCD4-Positive T-LymphocytesCell DifferentiationEnzyme-Linked Immunosorbent AssayFlow CytometryInflammationIntegrin alpha4beta1Interleukin-17Interleukin-23Interleukin-6InterleukinsMiceMice, TransgenicNuclear Receptor Subfamily 1, Group F, Member 3Polymerase Chain ReactionReceptors, CCR6Receptors, Retinoic AcidReceptors, Thyroid HormoneThymus GlandT-Lymphocyte SubsetsTransforming Growth Factor betaICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus
Odegard JM, DiPlacido LD, Greenwald L, Kashgarian M, Kono DH, Dong C, Flavell RA, Craft J. ICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus. The Journal Of Immunology 2009, 182: 4076-4084. PMID: 19299705, PMCID: PMC2746004, DOI: 10.4049/jimmunol.0800758.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Differentiation, T-LymphocyteAutoantibodiesAutoantigensB-LymphocytesCD4-Positive T-LymphocytesChemokine CXCL9Chemotaxis, LeukocyteCytokinesDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFlow CytometryFluorescent Antibody TechniqueInducible T-Cell Co-Stimulator ProteinKidneyLupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred MRL lprMice, TransgenicP-SelectinReceptors, CCR5Receptors, CXCR3ConceptsCD4 T cellsT cellsPerivascular infiltratesP-selectin ligandsMurine lupusReceptor expressionEffector functionsAutoreactive CD4 T cellsKidney-infiltrating T cellsEffector CD4 T cellsChemokine protein levelsEffector cell numbersIgG autoantibody productionExpression of CXCR3Effector T cellsSystemic lupus erythematosusImmune complex glomerulonephritisCellular inflammatory responseAutoantibody depositionComplex glomerulonephritisLupus erythematosusAutoantibody productionInflammatory chemokinesInflammatory cytokinesLigands CXCL9
2004
Activation of Naive CD4+ T Cells In Vivo by a Self-Peptide Mimic: Mechanism of Tolerance Maintenance and Preservation of Immunity
Choi JY, Craft J. Activation of Naive CD4+ T Cells In Vivo by a Self-Peptide Mimic: Mechanism of Tolerance Maintenance and Preservation of Immunity. The Journal Of Immunology 2004, 172: 7399-7407. PMID: 15187117, DOI: 10.4049/jimmunol.172.12.7399.Peer-Reviewed Original ResearchConceptsSelf peptide-MHC complexesT cellsTolerance maintenanceCostimulatory signalsMHC complexesNaive T cellsTCR engagementIntrathymic selectionNaive CD4Peripheral repertoireStrong costimulationForeign AgsAgonist peptideMicrobial challengeSurviving cellsNovel mechanismCellsVivoSubsequent encountersLow affinityPathogen challengeDividing cellsCD4CD69Restimulation
2003
CD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo
Bouzahzah F, Jung S, Craft J. CD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo. The Journal Of Immunology 2003, 170: 741-748. PMID: 12517936, DOI: 10.4049/jimmunol.170.2.741.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAutoantigensCD4-Positive T-LymphocytesCell DivisionCell SeparationCells, CulturedClonal AnergyEpitopes, T-LymphocyteGenetic Predisposition to DiseaseLupus NephritisLymphocyte CountMiceMice, Inbred C57BLMice, Inbred CBAMice, Inbred MRL lprMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaConceptsPigeon cytochrome cT cellsIL-2Self-AgCostimulatory signalsAntigen-specific tolerance inductionMRL xTCR transgenic T cellsLupus-prone MRL miceMRL T cellsNormal tolerance mechanismsUbiquitous self-AgsVivo Ag stimulationLupus-prone miceSuch T cellsPeripheral tolerance mechanismsCBA/CaJControl T cellsEx vivo recall assaysActivated T cellsT cell activationInappropriate T-cell activationThymic toleranceMRL/Recall assays
2001
From T to B and back again: positive feedback in systemic autoimmune disease
Shlomchik M, Craft J, Mamula M. From T to B and back again: positive feedback in systemic autoimmune disease. Nature Reviews Immunology 2001, 1: 147-153. PMID: 11905822, DOI: 10.1038/35100573.Peer-Reviewed Original ResearchConceptsSystemic autoimmune diseaseAutoimmune diseasesPrototypical systemic autoimmune diseaseSystemic lupus erythematosusPerpetuation of autoimmunityLoss of toleranceAutoantigen targetsLupus erythematosusAutoimmune stateB cellsImmune systemNuclear autoantigensDiseaseErythematosusAutoimmunityAutoantigens
2000
γδ T cells in autoimmunity
Yin Z, Craft J. γδ T cells in autoimmunity. Seminars In Immunopathology 2000, 22: 311-320. PMID: 11116960, DOI: 10.1007/s002810000048.Peer-Reviewed Original Research
1998
Influence of antigen organization on the development of lupus autoantibodies
Fatenejad S, Bennett M, Moslehi J, Craft J. Influence of antigen organization on the development of lupus autoantibodies. Arthritis & Rheumatism 1998, 41: 603-612. PMID: 9550469, DOI: 10.1002/1529-0131(199804)41:4<603::aid-art7>3.0.co;2-e.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesAutoantibodiesAutoantigensGene ExpressionHeLa CellsHumansImmune ToleranceImmunizationLupus Erythematosus, SystemicMiceMice, Inbred C57BLMice, Inbred StrainsRecombinant Fusion ProteinsRecombinant ProteinsRibonucleoprotein, U1 Small NuclearRibonucleoproteins, Small NuclearRNA-Binding ProteinsT-LymphocytesTumor Cells, CulturedConceptsSystemic lupus erythematosusDevelopment of antibodiesH-2b backgroundDevelopment of lupusT cell responsesT cell toleranceAssessment of antibodiesNative snRNP particlesTypical immune responseLupus erythematosusAutoimmune responseNormal miceAntigen organizationImmune responseForeign immunogensH-2kCell toleranceMajor autoantigenCell responsesMiceRandom orderAntibodiesEukaryotic expression vectorLupusAutoantigens
1997
Self antigens and epitope spreading in systemic autoimmunity
Craft J, Fatenejad S. Self antigens and epitope spreading in systemic autoimmunity. Arthritis & Rheumatism 1997, 40: 1374-1382. PMID: 9259415, DOI: 10.1002/art.1780400803.Peer-Reviewed Original ResearchThe transcriptional activator Sp1, a novel autoantigen
Spain T, Sun R, Gradzka M, Lin S, Craft J, Miller G. The transcriptional activator Sp1, a novel autoantigen. Arthritis & Rheumatism 1997, 40: 1085-1095. PMID: 9182919, DOI: 10.1002/art.1780400613.Peer-Reviewed Original ResearchConceptsTranscriptional activator Sp1Novel autoantigenComplex of DNAGC-rich sequencesActivator Sp1Undifferentiated connective tissue diseaseSp1 proteinTranscription activatorConnective tissue diseaseExtractable nuclear antigensEpstein-Barr virusSp1Nuclear extractsCellular DNAMalar rashAntinuclear antibodiesClinical characteristicsProteinDNARaynaud's phenomenonTissue diseaseAutoantigenic proteinsAutoimmune seraElectrophoretic mobilityAutoantigensScleroderma: A disease related to damaged proteins?
Peng S, Fatenejad S, Craft J. Scleroderma: A disease related to damaged proteins? Nature Medicine 1997, 3: 276-278. PMID: 9055850, DOI: 10.1038/nm0397-276.Peer-Reviewed Original ResearchRevisiting autoantibody profiles in systemic lupus erythematosus.
Olhoffer IH, Peng SL, Craft J. Revisiting autoantibody profiles in systemic lupus erythematosus. The Journal Of Rheumatology 1997, 24: 297-302. PMID: 9034986.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusImmune dysregulationLupus erythematosusAutoantibody profileAutoimmune responseAutoantibody specificitiesU1-RNPGlobal immune dysregulationAutoantibody-positive patientsSoluble autoantigensUbiquitous autoantigensPositive patientsIndividual patientsRetrospective analysisPatientsErythematosusAutoantibodiesAutoantigensDysregulationSpecificityBroad spectrumAutoimmunityDefinitive assayPrevalence
1996
Induction of nonpathologic, humoral autoimmunity in lupus-prone mice by a class II-restricted, transgenic alpha beta T cell. Separation of autoantigen-specific and -nonspecific help.
Peng SL, Fatenejad S, Craft J. Induction of nonpathologic, humoral autoimmunity in lupus-prone mice by a class II-restricted, transgenic alpha beta T cell. Separation of autoantigen-specific and -nonspecific help. The Journal Of Immunology 1996, 157: 5225-30. PMID: 8955166, DOI: 10.4049/jimmunol.157.12.5225.Peer-Reviewed Original ResearchConceptsAlpha beta T cellsBeta T cellsLupus-prone miceT cellsAutoantibody productionMurine lupusAnti-small nuclear ribonucleoproteinLpr/lpr miceEnd-organ diseaseRheumatoid factor titerSuch T cellsImmune complex diseaseT cell helpT cell specificitySalivary gland lesionsHumoral autoimmunityLpr miceCell helpOvert diseaseSerum IgGland lesionsClass IIDiseaseMiceAutoimmunityAutoimmunity to RNA polymerase II is focused at the carboxyl terminal domain of the large subunit
Hirakata M, Kanungo J, Suwa A, Takeda Y, Craft J, Hardin J. Autoimmunity to RNA polymerase II is focused at the carboxyl terminal domain of the large subunit. Arthritis & Rheumatism 1996, 39: 1886-1891. PMID: 8912511, PMCID: PMC6007873, DOI: 10.1002/art.1780391115.Peer-Reviewed Original ResearchAnti-U5 Small Nuclear Ribonucleoprotein (snRNP) Antibodies: A Rare Anti-U snRNP Specificity
Okano Y, Targoff I, Oddis C, Fujii T, Kuwana M, Tsuzaka K, Hirakata M, Mimori T, Craft J, Medsger T. Anti-U5 Small Nuclear Ribonucleoprotein (snRNP) Antibodies: A Rare Anti-U snRNP Specificity. Clinical Immunology 1996, 81: 41-47. PMID: 8808640, DOI: 10.1006/clin.1996.0155.Peer-Reviewed Original Research
1995
Molecular Structure and Function of Autoantigens in Systemic Sclerosis
Lee B, Craft J. Molecular Structure and Function of Autoantigens in Systemic Sclerosis. International Reviews Of Immunology 1995, 12: 129-144. PMID: 7650417, DOI: 10.3109/08830189509056708.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NuclearAutoantigensChromosomal Proteins, Non-HistoneDNA HelicasesDNA Topoisomerases, Type IDNA-Binding ProteinsDNA-Directed RNA PolymerasesEndoribonucleasesExoribonucleasesExosome Multienzyme Ribonuclease ComplexHumansKinetochoresKu AutoantigenNuclear ProteinsPol1 Transcription Initiation Complex ProteinsRibonucleoproteinsScleroderma, SystemicTranscription Factors
1994
The expression of self antigenic determinants: implications for tolerance and autoimmunity
Mamula M, Craft J. The expression of self antigenic determinants: implications for tolerance and autoimmunity. Current Opinion In Immunology 1994, 6: 882-886. PMID: 7536009, DOI: 10.1016/0952-7915(94)90008-6.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsT cellsSelf peptidesSelf antigenic determinantsT cell responsesPathogenesis of autoimmunityMajor histocompatibility moleculesNormal lymphocytesAntigen processingAntigenic determinantsHistocompatibility moleculesAutoimmunityCell surface proteinsNormal pathwayCellsPeptidesLymphocytesPathogenesisB cells process and present lupus autoantigens that initiate autoimmune T cell responses.
Mamula MJ, Fatenejad S, Craft J. B cells process and present lupus autoantigens that initiate autoimmune T cell responses. The Journal Of Immunology 1994, 152: 1453-61. PMID: 8301145, DOI: 10.4049/jimmunol.152.3.1453.Peer-Reviewed Original ResearchConceptsT cell responsesAutoimmune T cell responsesT cellsCell responsesB cellsAnti-snRNP antibodiesCross-reactive B cellsNon-autoimmune miceT cell toleranceB-cell processesSera of humansCross-reactive determinantsNative snRNP particlesMouse AgAutoreactive CD4Naive miceAutoantibody responseAutoreactive cellsMurine lupusTh cellsCommon findingSelf-AgCell toleranceMolecular mimicryMice
1993
Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera.
Hirakata M, Craft J, Hardin JA. Autoantigenic epitopes of the B and D polypeptides of the U1 snRNP. Analysis of domains recognized by the Y12 monoclonal anti-Sm antibody and by patient sera. The Journal Of Immunology 1993, 150: 3592-601. PMID: 7682245, DOI: 10.4049/jimmunol.150.8.3592.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, MonoclonalAutoantigensBinding Sites, AntibodyEnzyme-Linked Immunosorbent AssayEpitopesHumansImmune SeraLupus Erythematosus, SystemicMiceMolecular Sequence DataProtein ConformationRibonucleoprotein, U1 Small NuclearRibonucleoproteins, Small NuclearSnRNP Core ProteinsConceptsAnti-Sm antibodiesMonoclonal anti-Sm antibodyPatient seraCross-reactive epitopesAutoantigenic epitopesAnti-Sm seraPolypeptide BD polypeptideAnti-Sm patient seraSerumSpecific markersSm small nuclear ribonucleoproteinsEpitopesEnd deletionsAntibodiesImmunoreactive sitesCorresponding synthetic peptideB'/BMAbsDeletion studiesPresent studyLittle amino acid sequence homologySynthetic peptidesAmino acid sequence homologySLE
1992
Autoantigenic epitopes of the b polypeptide of SM small nuclear RNP particles
Ohosone Y, Mimori T, Fujii T, Akizuki M, Matsuoka Y, Irimajiri S, Hardin J, Craft J, Homma M. Autoantigenic epitopes of the b polypeptide of SM small nuclear RNP particles. Arthritis & Rheumatism 1992, 35: 960-966. PMID: 1379432, DOI: 10.1002/art.1780350818.Peer-Reviewed Original Research