2012
Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens
Jog NR, Frisoni L, Shi Q, Monestier M, Hernandez S, Craft J, Prak ET, Caricchio R. Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens. Arthritis & Rheumatism 2012, 64: 1247-1256. PMID: 22127758, PMCID: PMC3292632, DOI: 10.1002/art.33448.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoimmune responseMouse modelApoptotic cellsNuclear autoantigensDNA antibody titersLupus-prone miceAbsence of CADMaintenance of toleranceAutoreactive B cellsAnti-DNA antibodiesApoptotic modificationsLupus developmentGeneration of autoantigensAntinuclear antibodiesLupus erythematosusAntibody titersAutoimmune diseasesActive caspase-3Apoptotic bodiesB cellsMiceAutoantigensCAD deficiencyCaspase-3
2008
Editing Antigen Presentation: Antigen Transfer between Human B Lymphocytes and Macrophages Mediated by Class A Scavenger Receptors
Harvey BP, Quan TE, Rudenga BJ, Roman RM, Craft J, Mamula MJ. Editing Antigen Presentation: Antigen Transfer between Human B Lymphocytes and Macrophages Mediated by Class A Scavenger Receptors. The Journal Of Immunology 2008, 181: 4043-4051. PMID: 18768860, PMCID: PMC2701691, DOI: 10.4049/jimmunol.181.6.4043.Peer-Reviewed Original ResearchConceptsHuman B lymphocytesB lymphocytesImmune responseB cellsB cell-directed therapiesChronic autoimmune responseCell-directed therapiesScavenger receptor ASpecific B cellsClass A Scavenger ReceptorB cell APCDendritic cellsAntigen transferAutoimmune responseProfessional APCsEfficient APCsAntigen presentationTransfer of AgSpecific AgReceptor AScavenger receptorsMacrophagesLymphocytesAPCReceptors
1998
Influence of antigen organization on the development of lupus autoantibodies
Fatenejad S, Bennett M, Moslehi J, Craft J. Influence of antigen organization on the development of lupus autoantibodies. Arthritis & Rheumatism 1998, 41: 603-612. PMID: 9550469, DOI: 10.1002/1529-0131(199804)41:4<603::aid-art7>3.0.co;2-e.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesAutoantibodiesAutoantigensGene ExpressionHeLa CellsHumansImmune ToleranceImmunizationLupus Erythematosus, SystemicMiceMice, Inbred C57BLMice, Inbred StrainsRecombinant Fusion ProteinsRecombinant ProteinsRibonucleoprotein, U1 Small NuclearRibonucleoproteins, Small NuclearRNA-Binding ProteinsT-LymphocytesTumor Cells, CulturedConceptsSystemic lupus erythematosusDevelopment of antibodiesH-2b backgroundDevelopment of lupusT cell responsesT cell toleranceAssessment of antibodiesNative snRNP particlesTypical immune responseLupus erythematosusAutoimmune responseNormal miceAntigen organizationImmune responseForeign immunogensH-2kCell toleranceMajor autoantigenCell responsesMiceRandom orderAntibodiesEukaryotic expression vectorLupusAutoantigens
1997
Revisiting autoantibody profiles in systemic lupus erythematosus.
Olhoffer IH, Peng SL, Craft J. Revisiting autoantibody profiles in systemic lupus erythematosus. The Journal Of Rheumatology 1997, 24: 297-302. PMID: 9034986.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusImmune dysregulationLupus erythematosusAutoantibody profileAutoimmune responseAutoantibody specificitiesU1-RNPGlobal immune dysregulationAutoantibody-positive patientsSoluble autoantigensUbiquitous autoantigensPositive patientsIndividual patientsRetrospective analysisPatientsErythematosusAutoantibodiesAutoantigensDysregulationSpecificityBroad spectrumAutoimmunityDefinitive assayPrevalence
1993
Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles.
Fatenejad S, Mamula MJ, Craft J. Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 12010-12014. PMID: 8265662, PMCID: PMC48115, DOI: 10.1073/pnas.90.24.12010.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoreactive T cellsLupus erythematosusT cellsAutoantibody productionSuch miceAutoreactive helper T cellsHelper T-cell determinantsHelper T cellsT cell determinantsAutoantibody responseAutoimmune responseAntibody responseNormal miceImmune responseB cellsAutoantibodiesErythematosusMiceCentral targetPatientsImmunizationSnRNP particlesCellsMolecular mimics
1992
Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in japanese patients with inflammatory muscle disease
Hirakata M, Mimori T, Akizuki M, Craft J, Hardin J, Homma M. Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in japanese patients with inflammatory muscle disease. Arthritis & Rheumatism 1992, 35: 449-456. PMID: 1567494, DOI: 10.1002/art.1780350415.Peer-Reviewed Original ResearchConceptsInflammatory muscle diseaseJapanese patientsChronic interstitial lung diseaseMuscle diseaseAnti-PM/SclDifferent etiologic mechanismsTRNA synthetase antibodiesDistinct clinical subsetInterstitial lung diseasePM/DMControl patientsImmunogenetic backgroundOverlap syndromeClinical subsetsRheumatic diseasesSevere myositisAutoimmune responseRNP antibodiesAutoantibody specificitiesLung diseaseClinical correlationClinical significanceClinical comparisonSynthetase antibodiesEtiologic mechanisms
1988
Murine graft vs host disease. A model for study of mechanisms that generate autoantibodies to ribonucleoproteins.
Gelpi C, Rodriguez-Sanchez JL, Martinez MA, Craft J, Hardin JA. Murine graft vs host disease. A model for study of mechanisms that generate autoantibodies to ribonucleoproteins. The Journal Of Immunology 1988, 140: 4160-6. PMID: 3372998, DOI: 10.4049/jimmunol.140.12.4160.Peer-Reviewed Original ResearchConceptsHost diseaseChronic graftAutoimmune responseMixed connective tissue diseaseInduction of graftConnective tissue diseaseHuman rheumatic diseasesAnti-U1 RNPAntinuclear antibodiesMurine graftRheumatic diseasesRNP autoantibodiesTissue diseaseAutoantigenic epitopesLymphoid cellsJ strainAdditional seraGraftDiseaseMiceSerumAntibodiesAutoantibodiesMaximal levelsHuman serum
1987
Linked sets of antinuclear antibodies: what do they mean?
Craft JE, Hardin JA. Linked sets of antinuclear antibodies: what do they mean? Journal Of Rheumatology Supplement 1987, 14 Suppl 13: 106-9. PMID: 2441041.Peer-Reviewed Original ResearchPatterns of Autoimmunity to Nucleoproteins in Patients with Systemic Lupus Erythematosus
Hardin J, Craft J. Patterns of Autoimmunity to Nucleoproteins in Patients with Systemic Lupus Erythematosus. Rheumatic Disease Clinics Of North America 1987, 13: 37-46. PMID: 3306823, DOI: 10.1016/s0889-857x(21)00820-6.Peer-Reviewed Original ResearchConceptsAnti-Ro antibodiesAnti-DNA antibodiesAnti-Sm antibodiesAutoimmune responseAnti-U1 RNP antibodiesB lymphocyte hyperactivityPatterns of autoimmunitySystemic lupus erythematosusRo particleAnti-U1 RNPAnti-La antibodiesB lymphocyte clonesLupus erythematosusRNP antibodiesImmune regulationImmune responseH2B antibodiesAntibodiesAnti-histone H1Different antibodiesNucleoproteinResponseGeneral defectErythematosusAutoantibodies