1999
Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site
Foley J, Wysolmerski J, Missero C, King C, Philbrick W. Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site. Molecular And Cellular Endocrinology 1999, 156: 13-23. PMID: 10612419, DOI: 10.1016/s0303-7207(99)00151-3.Peer-Reviewed Original ResearchMeSH KeywordsAdenovirus E1A ProteinsAnimalsBase SequenceBinding SitesCell Line, TransformedEnhancer Elements, GeneticGene Expression RegulationGenes, rasGenes, ReporterKeratinocytesLuciferasesMiceParathyroid HormoneParathyroid Hormone-Related ProteinPromoter Regions, GeneticProtein IsoformsProteinsProto-Oncogene Protein c-ets-1Proto-Oncogene ProteinsProto-Oncogene Proteins c-etsRNA, MessengerTranscription FactorsTranscription, GeneticConceptsGene expressionBasal promoterReporter constructsEts-1 siteMinimal promoter regionProtein gene expressionTransient transfection assaysReporter gene activityRepressor domainE1A oncoproteinGene activityRas transformationE1A isoformsMurine keratinocyte lineSite upstreamReporter geneTransfection assaysPromoter regionParathyroid hormone-related protein gene expression
1994
HYPERCALCEMIA OF MALIGNANCY: The Central Role of Parathyroid Hormone-Related Protein
Wysolmerski J, Broadus A. HYPERCALCEMIA OF MALIGNANCY: The Central Role of Parathyroid Hormone-Related Protein. Annual Review Of Medicine 1994, 45: 189-200. PMID: 8198376, DOI: 10.1146/annurev.med.45.1.189.Peer-Reviewed Original ResearchConceptsLocal osteolytic hypercalcemiaMalignancy-associated hypercalcemiaHormone-related protein gene expressionParathyroid hormone-related proteinCommon metabolic complicationCommon clinical problemLocal paracrine factorsHormone-related proteinParathyroid hormone-related protein gene expressionHHM syndromeMetabolic complicationsHumoral hypercalcemiaParathyroid hormoneBone resorptionHypercalcemiaParacrine roleClinical problemParacrine factorsSyndromeRecent dataProtein gene expressionHormoneMolecular mechanismsGene expressionComplications