2015
Measurement of Bmax and Kd with the Glycine Transporter 1 Radiotracer 18F-MK6577 using a Novel Multi-Infusion Paradigm
Xia Y, Zheng MQ, Holden D, Lin SF, Kapinos M, Ropchan J, Gallezot JD, Huang Y, Carson RE. Measurement of Bmax and Kd with the Glycine Transporter 1 Radiotracer 18F-MK6577 using a Novel Multi-Infusion Paradigm. Cerebrovascular And Brain Metabolism Reviews 2015, 35: 2001-2009. PMID: 26198176, PMCID: PMC4671121, DOI: 10.1038/jcbfm.2015.163.Peer-Reviewed Original ResearchConceptsGlycine transporter-1 inhibitorNew positron emission tomography radiotracerPositron emission tomography (PET) radiotracerPotential therapeutic agentNondisplaceable distribution volumeNMDA receptorsVivo affinityBaboon brainDistribution volumeBmax valuesTomography radiotracerTherapeutic agentsVivo KDBrainRank orderUnlabeled compoundsRadiotracerKdBrainstem
2005
Quantification in vivo of nicotinic acetylcholine receptors density and affinity in the baboon brain using 2-[18F]fluoro-A-85380 and a multi-injection approach
Gallezot J, Grégoire M, Bottlaender M, Frédéric D, Wadad S, Coulon C, Ottaviani M, Delforge J, Syrota A, Valette H. Quantification in vivo of nicotinic acetylcholine receptors density and affinity in the baboon brain using 2-[18F]fluoro-A-85380 and a multi-injection approach. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s667-s667. DOI: 10.1038/sj.jcbfm.9591524.0667.Peer-Reviewed Original Research