1994
Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years
Mahl T, Shockcor W, Boyer J. Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years. Journal Of Hepatology 1994, 20: 707-713. PMID: 7930469, DOI: 10.1016/s0168-8278(05)80139-4.Peer-Reviewed Original ResearchConceptsTime of diagnosisAsymptomatic patientsSurvival of patientsGender-matched control populationPrimary biliary cirrhosisMedian followElevated bilirubinOverall survivalSymptomatic patientsAdvanced fibrosisBile stasisBiliary cirrhosisIndependent predictorsLiver biopsyLiver diseaseDiminished survivalLarge cohortPatientsOriginal diagnosisAccurate followControl populationSymptomsSurvival dataDiagnosisSurvival
1983
The Prognostic Importance of Clinical and Histologic Features in Asymptomatic and Symptomatic Primary Biliary Cirrhosis
Roll J, Boyer J, Barry D, Klatskin G. The Prognostic Importance of Clinical and Histologic Features in Asymptomatic and Symptomatic Primary Biliary Cirrhosis. New England Journal Of Medicine 1983, 308: 1-7. PMID: 6847917, DOI: 10.1056/nejm198301063080101.Peer-Reviewed Original ResearchConceptsPrimary biliary cirrhosisBiliary cirrhosisPoor prognosisSymptomatic primary biliary cirrhosisOnset of diseaseAsymptomatic patientsAsymptomatic diseaseClinical featuresHistologic featuresHistologic stagePrediction of riskPrognostic importanceSerum bilirubinHepatic fibrosisHistologic findingsPortal areasProlonged survivalMultivariate analysisPatientsControl populationPrognosisWeight lossElevated levelsLife expectancySurvival data