1984
Isolated rat hepatocyte couplets: a primary secretory unit for electrophysiologic studies of bile secretory function.
Graf J, Gautam A, Boyer J. Isolated rat hepatocyte couplets: a primary secretory unit for electrophysiologic studies of bile secretory function. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6516-6520. PMID: 6149546, PMCID: PMC391955, DOI: 10.1073/pnas.81.20.6516.Peer-Reviewed Original ResearchConceptsBile secretory functionElectrophysiologic studySecretory functionHepatocyte coupletsOrganic anion fluoresceinSteady-state intracellularCanalicular lumenCanalicular vacuoleInput resistanceRat liverCollagenase perfusionIntact liverLiverSecretionParacellular barrierBile canalicular lumenSecretory unitsLumenCellsJunctional pathwayElectrical driving forcePerfusion
1982
Hemodynamic effects on oxygen consumption and bile flow in isolated skate liver
Reed J, Smith N, Boyer J. Hemodynamic effects on oxygen consumption and bile flow in isolated skate liver. American Journal Of Physiology 1982, 242: g313-g318. PMID: 7065253, DOI: 10.1152/ajpgi.1982.242.4.g313.Peer-Reviewed Original ResearchConceptsPerfusion pressureBile flowSkate liverOxygen consumptionOrganic anion clearanceBile flow ratePortal vein pressurePerfusion of liversHemodynamic effectsVein pressureBile secretionFractional disappearance rateHepatic clearanceLiverDisappearance rateRinger's solutionPerfusionBileClearanceTaurocholateRaja erinaceaSulfobromophthaleinVivoMammalian speciesPerfusate
1979
Effect of chlorpromazine on hepatic perfusion and bile secretory function in the isolated perfused rat liver.
Tavoloni N, Reed J, Hruban Z, Boyer J. Effect of chlorpromazine on hepatic perfusion and bile secretory function in the isolated perfused rat liver. Translational Research 1979, 94: 726-41. PMID: 227976.Peer-Reviewed Original ResearchConceptsHepatic perfusionPerfusate flowBile secretionBile acid-independent bile secretionSecretory functionBile acid excretionBile secretory functionRat liverEffect of chlorpromazineLiver 20 minLobar distributionHepatic lobeAcid excretionBaseline valuesPerfusate concentrationConstant infusionHepatic ultrastructureBile acidsControl valuesCPZSodium taurocholateLiverPerfusionGM-1Liver plasma membranes