2017
Reevaluating the Efficacy and Predictability of Antidepressant Treatments: A Symptom Clustering Approach
Chekroud AM, Gueorguieva R, Krumholz HM, Trivedi MH, Krystal JH, McCarthy G. Reevaluating the Efficacy and Predictability of Antidepressant Treatments: A Symptom Clustering Approach. JAMA Psychiatry 2017, 74: 370-378. PMID: 28241180, PMCID: PMC5863470, DOI: 10.1001/jamapsychiatry.2017.0025.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAffectAgedAntidepressive AgentsBupropionCitalopramCluster AnalysisDepressive Disorder, MajorDose-Response Relationship, DrugDrug Therapy, CombinationDuloxetine HydrochlorideFemaleHumansMaleMianserinMiddle AgedMirtazapineRandomized Controlled Trials as TopicSleepSyndromeTreatment OutcomeVenlafaxine HydrochlorideYoung AdultConceptsCore emotional symptomsDepressive severitySymptom clustersHamilton Depression Rating ScaleDepression Outcomes trialDifferent antidepressant medicationsHAM-D scaleHigh-dose duloxetinePhase 3 trialEmotional symptomsPatient-reported dataDepression Rating ScaleSequenced Treatment AlternativesGroup of symptomsCluster of symptomsDepressive symptom checklistMixed-effects regression analysisDepressive Symptomatology ScaleAntidepressant therapyAntidepressant treatmentAntidepressant medicationOutcome trialsCombining MedicationsAtypical symptomsAdditional placebo
2006
Time Course of Depression and Outcome of Myocardial Infarction
Parashar S, Rumsfeld JS, Spertus JA, Reid KJ, Wenger NK, Krumholz HM, Amin A, Weintraub WS, Lichtman J, Dawood N, Vaccarino V. Time Course of Depression and Outcome of Myocardial Infarction. JAMA Internal Medicine 2006, 166: 2035-2043. PMID: 17030839, DOI: 10.1001/archinte.166.18.2035.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAngina, UnstableAntidepressive AgentsDepressionFemaleHealth StatusHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOutcome Assessment, Health CarePatient ReadmissionPrognosisProspective StudiesQuality of LifeRegistriesSeverity of Illness IndexSurveys and QuestionnairesTime FactorsUnited StatesConceptsPatient Health QuestionnaireMyocardial infarctionDepressive symptomsPrognostic importanceWorse outcomesPersistent depressionHealth statusAdjusted hazard ratioAcute myocardial infarctionCorresponding odds ratiosCategories of depressionMore physical limitationsTime courseFrequent anginaHigher rehospitalizationCause rehospitalizationNondepressed patientsProspective registryHazard ratioOdds ratioHealth QuestionnaireMortality rateDisease severityRehospitalizationFirst month