2022
Trends in 10-Year Outcomes Among Medicare Beneficiaries Who Survived an Acute Myocardial Infarction
Wang Y, Leifheit EC, Krumholz HM. Trends in 10-Year Outcomes Among Medicare Beneficiaries Who Survived an Acute Myocardial Infarction. JAMA Cardiology 2022, 7: 613-622. PMID: 35507330, PMCID: PMC9069341, DOI: 10.1001/jamacardio.2022.0662.Peer-Reviewed Original ResearchConceptsRecurrent acute myocardial infarctionAcute myocardial infarctionHealth priority areasLong-term outcomesCause mortalityHazard ratioWhite patientsMyocardial infarctionMedicare feeMedicare-MedicaidService beneficiariesInitial acute myocardial infarctionTen-year mortalityShort-term outcomesDemographic subgroupsEligible patientsPatient characteristicsAMI survivorsAcute periodMean ageRecurrence rateSubgroup analysisMAIN OUTCOMEMortality riskAMI admissions
2020
Antiplatelet strategies in acute coronary syndromes: design and methodology of an international collaborative network meta-analysis of randomized controlled trials.
Madhavan M, Bikdeli B, Redfors B, Biondi-Zoccai G, Varunok N, Burton J, Crowley A, Francese D, Gupta A, DER Nigoghossian C, Chatterjee S, Palmerini T, Benedetto U, You S, Ohman E, Kastrati A, Steg P, Gibson C, Angiolillo D, Krumholz H, Stone G. Antiplatelet strategies in acute coronary syndromes: design and methodology of an international collaborative network meta-analysis of randomized controlled trials. Minerva Cardioangiologica 2020, 69: 398-407. PMID: 33258563, DOI: 10.23736/s2724-5683.20.05353-0.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeNetwork meta-analysisIncidence rate ratiosReceptor inhibitorsRandom-effects methodMeta-analysisCoronary syndromeMonths of follow-up timePatients of advanced ageControlled trialsBackground of aspirinEfficacy of prasugrelST-elevation myocardial infarctionCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsFollow-up timeFrequentist network meta-analysisManagement of patientsRegister of Controlled TrialsShort-term outcomesLong-term outcomesCochrane Central RegisterRandomized controlled trialsHemorrhagic outcomesAntiplatelet strategiesEvaluation of Case Volumes of a Heart Transplant Program and Short-term Outcomes After Changes in the United Network for Organ Sharing Donor Heart Allocation System
Mori M, Wilson L, Ali A, Ahmad T, Anwer M, Jacoby D, Geirsson A, Krumholz HM. Evaluation of Case Volumes of a Heart Transplant Program and Short-term Outcomes After Changes in the United Network for Organ Sharing Donor Heart Allocation System. JAMA Network Open 2020, 3: e2017513. PMID: 32945877, PMCID: PMC7501535, DOI: 10.1001/jamanetworkopen.2020.17513.Peer-Reviewed Original ResearchConceptsYale-New Haven HospitalHeart transplant programShort-term outcomesHeart transplantHeart transplant volumeNew Haven HospitalDonor heartsPatient selectionRecipient selectionTransplant programsTransplant volumeWaiting listCase volumeDonor heart allocation systemPre-post cohort studyConservative patient selectionUnused donor heartsHeart allocation systemHigher median numberCirculatory assist devicesCohort studyPatient characteristicsMore patientsSingle centerCenter volume
2012
Hospital-Level Outcomes Associated with Laparoscopic Colectomy for Cancer in the Minimally Invasive Era
Fox JP, Desai MM, Krumholz HM, Gross CP. Hospital-Level Outcomes Associated with Laparoscopic Colectomy for Cancer in the Minimally Invasive Era. Journal Of Gastrointestinal Surgery 2012, 16: 2112-2119. PMID: 22948842, PMCID: PMC3670114, DOI: 10.1007/s11605-012-2018-z.Peer-Reviewed Original ResearchConceptsLaparoscopy rateLaparoscopic colectomyShorter hospitalizationColon resectionHospital mortalityPostoperative morbidityLow postoperative morbidity rateHigher laparoscopy ratePostoperative morbidity rateRisk-standardized outcomesLow postoperative morbidityShorter hospital stayNationwide Inpatient SampleShort-term outcomesHigher procedure volumeHospital stayComparable morbidityRandomized trialsMorbidity rateInvasive eraInpatient SampleOutcomes AssociatedColectomyMortality rateProcedure volume
2010
Trends in Length of Stay and Short-term Outcomes Among Medicare Patients Hospitalized for Heart Failure, 1993-2006
Bueno H, Ross JS, Wang Y, Chen J, Vidán MT, Normand SL, Curtis JP, Drye EE, Lichtman JH, Keenan PS, Kosiborod M, Krumholz HM. Trends in Length of Stay and Short-term Outcomes Among Medicare Patients Hospitalized for Heart Failure, 1993-2006. JAMA 2010, 303: 2141-2147. PMID: 20516414, PMCID: PMC3020983, DOI: 10.1001/jama.2010.748.Peer-Reviewed Original ResearchConceptsLength of stayShort-term outcomesHeart failureReadmission ratesHospital mortalityDischarge dispositionRisk ratioThirty-day readmission ratesMortality risk ratioSkilled nursing facilitiesHome care servicesHospital stayOlder patientsUnadjusted analysesMedicare patientsObservational studyMedicare feeNursing facilitiesPatientsStayCare servicesMortalityMarked reductionMean lengthOutcomes
2007
The Prognostic Importance of a Small Acute Decrement in Kidney Function in Hospitalized Patients: A Systematic Review and Meta-Analysis
Coca SG, Peixoto AJ, Garg AX, Krumholz HM, Parikh CR. The Prognostic Importance of a Small Acute Decrement in Kidney Function in Hospitalized Patients: A Systematic Review and Meta-Analysis. American Journal Of Kidney Diseases 2007, 50: 712-720. PMID: 17954284, DOI: 10.1053/j.ajkd.2007.07.018.Peer-Reviewed Original ResearchConceptsSerum creatinine levelsCreatinine levelsRelative riskTerm mortalityAcute changesWorse short-term outcomesClinical settingRR of deathAcute kidney injuryObservational cohort studyShort-term outcomesGreater relative riskPercentage of changeAcute decrementsKidney injuryCohort studyRenal functionHospitalized patientsKidney functionPrognostic importanceEmbase databasesWorse outcomesAcute decreaseStatistical heterogeneityAbstractText
2003
Regional variation in the treatment and outcomes of myocardial infarction: investigating New England’s advantage
Krumholz HM, Chen J, Rathore SS, Wang Y, Radford MJ. Regional variation in the treatment and outcomes of myocardial infarction: investigating New England’s advantage. American Heart Journal 2003, 146: 242-249. PMID: 12891191, DOI: 10.1016/s0002-8703(03)00237-0.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAngioplasty, Balloon, CoronaryAspirinCoronary Artery BypassFemaleFibrinolytic AgentsHospitalizationHumansLogistic ModelsMaleMyocardial InfarctionNew EnglandOutcome Assessment, Health CarePractice Patterns, Physicians'Quality of Health CareThrombolytic TherapyUnited StatesConceptsPractice patternsMortality rateReperfusion therapyBetter short-term outcomesMedical therapy useShort-term outcomesQuality of careHierarchical logistic regression modelsMyocardial infarction treatmentLogistic regression modelsTherapy useMyocardial infarctionHospital characteristicsPhysician characteristicsProvider characteristicsBetter outcomesInfarction treatmentPatientsMI treatmentRegional variationLow useRegional differencesAspirinHospitalTherapy