2024
Hypertension Trends and Disparities Over 12 Years in a Large Health System: Leveraging the Electronic Health Records
Brush J, Lu Y, Liu Y, Asher J, Li S, Sawano M, Young P, Schulz W, Anderson M, Burrows J, Krumholz H. Hypertension Trends and Disparities Over 12 Years in a Large Health System: Leveraging the Electronic Health Records. Journal Of The American Heart Association 2024, 13: e033253. PMID: 38686864, PMCID: PMC11179912, DOI: 10.1161/jaha.123.033253.Peer-Reviewed Original ResearchConceptsElectronic health recordsRegional health systemImprove hypertension careHealth systemHealth recordsHypertension careDiastolic blood pressureAge-adjusted prevalence ratesNon-Hispanic Black patientsPrevalence ratesLarger health systemCross-sectional analysisTransformation of medical dataLeveraging real-world dataHigh prevalence rateHypertension trendsHypertension prevalenceBlood pressureBlood pressure measurementsHypertension diagnosisPrimary outcomeNational trendsProportion of patientsAntihypertensive medicationsBlack patients
2021
National Trends in the Use of Sacubitril/Valsartan
Ozaki AF, Krumholz HM, Mody FV, Jackevicius CA. National Trends in the Use of Sacubitril/Valsartan. Journal Of Cardiac Failure 2021, 27: 839-847. PMID: 34364661, DOI: 10.1016/j.cardfail.2021.05.015.Peer-Reviewed Original ResearchConceptsSacubitril/valsartanSacubitril/valsartan useReduced ejection fractionValsartan useEjection fractionHeart failurePopulation-level cohort studyNational Prescription AuditEligible patientsCohort studyPrescription patternsYounger patientsPrescription auditDosage patternClinical implicationsFurther evaluationValsartanPatientsSubstantial proportionNational trendsPrescriptionGreater increaseRecent useGreater proportionUnited States
2017
National Trends in Use and Outcomes of Pulmonary Artery Catheters Among Medicare Beneficiaries, 1999-2013
Ikuta K, Wang Y, Robinson A, Ahmad T, Krumholz HM, Desai NR. National Trends in Use and Outcomes of Pulmonary Artery Catheters Among Medicare Beneficiaries, 1999-2013. JAMA Cardiology 2017, 2: 908-913. PMID: 28593267, PMCID: PMC5815078, DOI: 10.1001/jamacardio.2017.1670.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCatheterization, Swan-GanzCohort StudiesCross-Sectional StudiesDisease ManagementFemaleHeart FailureHospital MortalityHospitalizationHumansLength of StayMaleMedicareMortalityMyocardial InfarctionPulmonary ArteryRespiratory InsufficiencyUnited StatesVascular Access DevicesConceptsAcute myocardial infarctionLength of stayPAC usePAC placementRespiratory failureHeart failureMyocardial infarctionClinical conditionsPulmonary artery catheter useNational trendsCross-sectional cohort studyStudy periodKey clinical conditionsMedicaid Services inpatientHeart failure admissionsPulmonary artery catheterClinical Modification codesSociodemographic groupsUnique Medicare beneficiariesLack of benefitRace/ethnicityService inpatientsHospital mortalityCatheter useArtery catheter
2015
National Trends in Pulmonary Embolism Hospitalization Rates and Outcomes for Adults Aged ≥65 Years in the United States (1999 to 2010)
Minges KE, Bikdeli B, Wang Y, Kim N, Curtis JP, Desai MM, Krumholz HM. National Trends in Pulmonary Embolism Hospitalization Rates and Outcomes for Adults Aged ≥65 Years in the United States (1999 to 2010). The American Journal Of Cardiology 2015, 116: 1436-1442. PMID: 26409636, PMCID: PMC4841688, DOI: 10.1016/j.amjcard.2015.07.068.Peer-Reviewed Original ResearchConceptsHospitalization ratesMortality rateReadmission ratesBlack patientsPrincipal discharge diagnosis codeOlder adultsCause readmission rateHospital mortality rateProportion of patientsRetrospective cohort studyDischarge diagnosis codesSkilled nursing facilitiesNational trendsSignificant racial differencesHigh rateHome health careHospital stayAdults AgedCohort studyMore patientsTherapeutic advancesDiagnosis codesMedicare feeNursing facilitiesSignificant burdenNational Trends in Hospital Readmission Rates among Medicare Fee-for-Service Survivors of Mitral Valve Surgery, 1999–2010
Dodson JA, Wang Y, Murugiah K, Dharmarajan K, Cooper Z, Hashim S, Nuti SV, Spatz E, Desai N, Krumholz HM. National Trends in Hospital Readmission Rates among Medicare Fee-for-Service Survivors of Mitral Valve Surgery, 1999–2010. PLOS ONE 2015, 10: e0132470. PMID: 26147225, PMCID: PMC4493110, DOI: 10.1371/journal.pone.0132470.Peer-Reviewed Original ResearchConceptsMitral valve surgeryLength of stayHospital LOSReadmission ratesHospital readmission ratesOlder patientsHospital readmissionMedicare feeMean hospital LOSSurvival rateProportional hazards regressionYears of ageValve surgeryHazards regressionService patientsWorse outcomesAge subgroupsPatientsOlder adultsSurvivorsNational trendsReadmissionModest declineWomenSubgroups
2014
National Trends in Patient Safety for Four Common Conditions, 2005–2011
Wang Y, Eldridge N, Metersky ML, Verzier NR, Meehan TP, Pandolfi MM, Foody JM, Ho SY, Galusha D, Kliman RE, Sonnenfeld N, Krumholz HM, Battles J. National Trends in Patient Safety for Four Common Conditions, 2005–2011. New England Journal Of Medicine 2014, 370: 341-351. PMID: 24450892, PMCID: PMC4042316, DOI: 10.1056/nejmsa1300991.Peer-Reviewed Original ResearchConceptsCongestive heart failureAcute myocardial infarctionMore adverse eventsProportion of patientsAdverse event ratesAdverse eventsHeart failureMyocardial infarctionRate of occurrenceCommon medical conditionsMedical recordsMedicare patientsMedical conditionsPatientsSurgeryInfarctionPneumoniaHospitalizationPatient safetyNational trendsMonitoring System dataSignificant declineFailureProportionRate
2013
National Trends in Heart Failure Hospitalization After Acute Myocardial Infarction for Medicare Beneficiaries
Chen J, Hsieh AF, Dharmarajan K, Masoudi FA, Krumholz HM. National Trends in Heart Failure Hospitalization After Acute Myocardial Infarction for Medicare Beneficiaries. Circulation 2013, 128: 2577-2584. PMID: 24190958, PMCID: PMC4415510, DOI: 10.1161/circulationaha.113.003668.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHF hospitalizationHeart failureMyocardial infarctionMedicare beneficiariesManagement of AMIHeart failure hospitalizationSubsequent HF hospitalizationNumber of patientsNational trendsHigh-risk conditionsContemporary national trendsRelative annual increaseDemographic factorsFailure hospitalizationPerson yearsClinical comorbiditiesNational sampleComplete national sampleHospitalizationMedicare feeAMI hospitalizationService beneficiariesAnnual declineStudy period
2010
Response to Letter Regarding Article, “Recent National Trends in Readmission Rates After Heart Failure Hospitalization”
Ross J, Krumholz H. Response to Letter Regarding Article, “Recent National Trends in Readmission Rates After Heart Failure Hospitalization”. Circulation Heart Failure 2010, 3: e17. DOI: 10.1161/circheartfailure.110.952895.Commentaries, Editorials and Letters
2009
Recent National Trends in Readmission Rates After Heart Failure Hospitalization
Ross JS, Chen J, Lin Z, Bueno H, Curtis JP, Keenan PS, Normand SL, Schreiner G, Spertus JA, Vidán MT, Wang Y, Wang Y, Krumholz HM. Recent National Trends in Readmission Rates After Heart Failure Hospitalization. Circulation Heart Failure 2009, 3: 97-103. PMID: 19903931, PMCID: PMC2830811, DOI: 10.1161/circheartfailure.109.885210.Peer-Reviewed Original ResearchConceptsCause readmission rateReadmission ratesHeart failureRecent national trendsHospital variationService beneficiariesAcute-care nonfederal hospitalsUS acute care hospitalsHeart failure hospitalizationHospital readmission ratesAcute care hospitalsNational trendsNational Quality ForumMedicare administrative dataDistinct hospitalizationsFailure hospitalizationMultiple comorbiditiesCare hospitalNonfederal hospitalsMedicare beneficiariesHospitalizationHospitalQuality ForumStudy periodAdministrative data
2006
National Trends in Outcomes Among Elderly Patients with Heart Failure
Kosiborod M, Lichtman JH, Heidenreich PA, Normand SL, Wang Y, Brass LM, Krumholz HM. National Trends in Outcomes Among Elderly Patients with Heart Failure. The American Journal Of Medicine 2006, 119: 616.e1-616.e7. PMID: 16828634, DOI: 10.1016/j.amjmed.2005.11.019.Peer-Reviewed Original ResearchConceptsHeart failure managementHeart failureElderly patientsHospital readmissionFailure managementOne-year mortalityThirty-day readmissionRisk-adjusted analysisCause hospital readmissionReferent yearCause mortalityReadmissionMedicare beneficiariesBetter outcomesMortality trendsMortalityPatientsRisk adjustmentTemporal trendsNational trendsOutcomesNational sampleFailureYears
2003
National trends in the care of patients with heart failure, 1998–2001: Results from the CMS National heart failure project
Masoudi F, Stevens B, Foody J, Havranek E, Krumholz H, Ordin D. National trends in the care of patients with heart failure, 1998–2001: Results from the CMS National heart failure project. Journal Of The American College Of Cardiology 2003, 41: 518. DOI: 10.1016/s0735-1097(03)82792-4.Peer-Reviewed Original Research