2018
Time to hospital arrival among patients with acute myocardial infarction in China: a report from China PEACE prospective study
Guan W, Venkatesh AK, Bai X, Xuan S, Li J, Li X, Zhang H, Zheng X, Masoudi FA, Spertus JA, Krumholz HM, Jiang L. Time to hospital arrival among patients with acute myocardial infarction in China: a report from China PEACE prospective study. European Heart Journal - Quality Of Care And Clinical Outcomes 2018, 5: 63-71. PMID: 29878087, PMCID: PMC6307335, DOI: 10.1093/ehjqcco/qcy022.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHospital arrivalSymptom onsetMyocardial infarctionMedical insuranceLower household incomeRural medical insuranceChest discomfortChest painIndex hospitalizationMedian timeMultivariable analysisAMI symptomsProspective studyAssociated FactorsPatients' perceptionsCare seekingAMI hospitalizationPatientsSymptomsHousehold incomeAMI studyHospitalizationInfarctionAverage time
2008
A Campaign to Improve the Timeliness of Primary Percutaneous Coronary Intervention Door-to-Balloon: An Alliance for Quality
Krumholz HM, Bradley EH, Nallamothu BK, Ting HH, Batchelor WB, Kline-Rogers E, Stern AF, Byrd JR, Brush JE. A Campaign to Improve the Timeliness of Primary Percutaneous Coronary Intervention Door-to-Balloon: An Alliance for Quality. JACC Cardiovascular Interventions 2008, 1: 97-104. PMID: 19393152, DOI: 10.1016/j.jcin.2007.10.006.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionD2B timeD2B AllianceCatheterization laboratoryPrimary percutaneous coronary interventionEmergency medical services personnelElevation myocardial infarctionMajority of patientsPercutaneous coronary interventionNon-transferred patientsAmerican Heart AssociationMedical services personnelEmergency medicine physiciansPre-hospital electrocardiogramTeam-based approachCoronary interventionHospital arrivalHeart AssociationMyocardial infarctionAmerican CollegeMedicine physiciansLikelihood of survivalPatientsUnderused strategyBalloon
2007
Impact of Delay in Door-to-Needle Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
McNamara RL, Herrin J, Wang Y, Curtis JP, Bradley EH, Magid DJ, Rathore SS, Nallamothu BK, Peterson ED, Blaney ME, Frederick P, Krumholz HM. Impact of Delay in Door-to-Needle Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction. The American Journal Of Cardiology 2007, 100: 1227-1232. PMID: 17920362, PMCID: PMC2715362, DOI: 10.1016/j.amjcard.2007.05.043.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArrhythmias, CardiacCaliforniaCohort StudiesEmergency Service, HospitalEmergency TreatmentFemaleFibrinolytic AgentsHospital MortalityHumansMaleMedical RecordsMyocardial InfarctionOutcome Assessment, Health CareRegistriesRetrospective StudiesThrombolytic TherapyTime and Motion StudiesTime FactorsConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionNeedle timeFibrinolytic therapyMyocardial infarctionHospital mortalitySymptom onsetOdds ratioReperfusion strategyAdjunctive medicationsHospital arrivalShorter doorTimely administrationNational registryRepresentative cohortPatientsMortalityInfarctionTherapyIndependent effectsCohortMinutesSmaller centersOnsetImpact of delay
2005
Hospital Improvement in Time to Reperfusion in Patients With Acute Myocardial Infarction, 1999 to 2002
McNamara RL, Herrin J, Bradley EH, Portnay EL, Curtis JP, Wang Y, Magid DJ, Blaney M, Krumholz HM, Investigators N. Hospital Improvement in Time to Reperfusion in Patients With Acute Myocardial Infarction, 1999 to 2002. Journal Of The American College Of Cardiology 2005, 47: 45-51. PMID: 16386663, PMCID: PMC1475926, DOI: 10.1016/j.jacc.2005.04.071.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionBalloon timeMin/yearNeedle timeMyocardial infarctionHospital characteristicsAcute ST-segment elevation myocardial infarctionPercutaneous coronary intervention cohortPercutaneous coronary intervention volumeElevation myocardial infarctionPercutaneous coronary interventionRetrospective observational studyFour-year study periodRapid reperfusionCoronary interventionFibrinolytic therapyHospital arrivalTherapy cohortReperfusion timeIntervention cohortNational registryIntervention volumeObservational studyHospital improvementPatients
2004
Racial and Ethnic Differences in Time to Acute Reperfusion Therapy for Patients Hospitalized With Myocardial Infarction
Bradley EH, Herrin J, Wang Y, McNamara RL, Webster TR, Magid DJ, Blaney M, Peterson ED, Canto JG, Pollack CV, Krumholz HM. Racial and Ethnic Differences in Time to Acute Reperfusion Therapy for Patients Hospitalized With Myocardial Infarction. JAMA 2004, 292: 1563-1572. PMID: 15467058, DOI: 10.1001/jama.292.13.1563.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryAsian PeopleBlack PeopleFemaleHispanic or LatinoHospitalsHumansInsurance, HospitalizationMaleMiddle AgedMyocardial InfarctionOutcome Assessment, Health CarePatient AdmissionRetrospective StudiesSocioeconomic FactorsThrombolytic TherapyTime and Motion StudiesTime FactorsUnited StatesWhite PeopleConceptsST-segment elevation myocardial infarctionAcute reperfusion therapyElevation myocardial infarctionMyocardial infarctionReperfusion therapyAfrican American/BlackBalloon timeInsurance statusAmerican/BlackEthnic differencesPercutaneous coronary interventionBundle branch blockAsian/Pacific IslandersHealth care disparitiesRace/ethnicity differencesRace/ethnicityClinical characteristicsCoronary interventionFibrinolytic therapyHospital arrivalNonwhite patientsPrimary reperfusionWhite patientsUS cohortHospital characteristics
2003
National and State Trends in Quality of Care for Acute Myocardial Infarction Between 1994-1995 and 1998-1999: The Medicare Health Care Quality Improvement Program
Burwen DR, Galusha DH, Lewis JM, Bedinger MR, Radford MJ, Krumholz HM, Foody JM. National and State Trends in Quality of Care for Acute Myocardial Infarction Between 1994-1995 and 1998-1999: The Medicare Health Care Quality Improvement Program. JAMA Internal Medicine 2003, 163: 1430-1439. PMID: 12824092, DOI: 10.1001/archinte.163.12.1430.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overAngioplasty, Balloon, CoronaryAngiotensin-Converting Enzyme InhibitorsAspirinFemaleHealth Care SurveysHumansMaleMedicareMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsQuality Indicators, Health CareQuality of Health CareSmoking CessationThrombolytic TherapyTime FactorsUnited StatesConceptsAcute myocardial infarctionQuality of careHospital arrivalEarly administrationMedian timeMyocardial infarctionPrimary percutaneous transluminal coronary angioplastyHealth Care Quality Improvement ProgramPercutaneous transluminal coronary angioplastyAcute reperfusion therapyBeta-blocker prescriptionEnzyme inhibitor prescriptionTransluminal coronary angioplastyGuideline-recommended processesQuality Improvement ProgramPopulation-based improvementsCessation counselingReperfusion therapySystolic dysfunctionInhibitor prescriptionCoronary angioplastyThrombolytic therapyMedicare patientsTherapyTime points
2001
The case for comprehensive quality indicator reliability assessment
Scinto J, Galusha D, Krumholz H, Meehan T. The case for comprehensive quality indicator reliability assessment. Journal Of Clinical Epidemiology 2001, 54: 1103-1111. PMID: 11675161, DOI: 10.1016/s0895-4356(01)00381-x.Peer-Reviewed Original ResearchConceptsComposite quality indicatorHospital medical recordsProcess of careRecent dischargeKappa valuesPrevalence effectBias-adjusted kappaHospital arrivalAntibiotic administrationMedical recordsOverall eligibilityOxygenation assessmentQuality indicatorsCareKappa statisticsInterrater agreementKappaEligibility
2000
Thrombolytic therapy in older patients
Berger A, Radford M, Wang Y, Krumholz H. Thrombolytic therapy in older patients. Journal Of The American College Of Cardiology 2000, 36: 366-374. PMID: 10933344, DOI: 10.1016/s0735-1097(00)00723-3.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrimary angioplastyThrombolytic therapyOlder patientsBundle branch blockAcute reperfusionBranch blockST-segment elevationPatients age 65Population-based cohortReperfusion strategyReperfusion therapyHospital arrivalSurvival benefitSymptom onsetSegment elevationPhysician factorsST elevationMyocardial infarctionNational cohortAngioplastyBetter survivalMedicare beneficiariesLower mortalityPatientsFactors associated with delay in reperfusion therapy in elderly patients with acute myocardial infarction: Analysis of the Cooperative Cardiovascular Project
Berger A, Radford M, Krumholz H. Factors associated with delay in reperfusion therapy in elderly patients with acute myocardial infarction: Analysis of the Cooperative Cardiovascular Project. American Heart Journal 2000, 139: 985-992. PMID: 10827378, DOI: 10.1067/mhj.2000.105703.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnistreplaseElectrocardiographyFemaleHumansMaleMyocardial InfarctionPatient AdmissionPlasminogen ActivatorsQuality Indicators, Health CareRetrospective StudiesRisk FactorsStreptokinaseSurvival RateThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorTreatment FailureUnited StatesConceptsAcute myocardial infarctionHospital arrivalElderly patientsMortality rateMyocardial infarctionCardiology/American Heart Association guidelinesAmerican Heart Association guidelinesAdministration of thrombolysisHistory of hypertensionHeart Association guidelinesCooperative Cardiovascular Project databaseCooperative Cardiovascular ProjectCardiac catheterization laboratoryReperfusion therapyClinical characteristicsHeart failureST elevationThrombolytic therapyAssociation guidelinesHospital characteristicsCatheterization laboratoryAmerican CollegeThrombolysisPatientsRapid treatment
1997
Quality of Care, Process, and Outcomes in Elderly Patients With Pneumonia
Meehan TP, Fine MJ, Krumholz HM, Scinto JD, Galusha DH, Mockalis JT, Weber GF, Petrillo MK, Houck PM, Fine JM. Quality of Care, Process, and Outcomes in Elderly Patients With Pneumonia. JAMA 1997, 278: 2080-2084. PMID: 9403422, DOI: 10.1001/jama.1997.03550230056037.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Bacterial AgentsBlood Specimen CollectionCenters for Medicare and Medicaid Services, U.S.FemaleHospital MortalityHumansLogistic ModelsMaleMedicareOutcome and Process Assessment, Health CarePneumoniaQuality Indicators, Health CareRetrospective StudiesSeverity of Illness IndexSurvival AnalysisUnited StatesConceptsBlood culture collectionProcess of careHospital arrivalElderly patientsAntibiotic administrationQuality of careBlood culturesMulticenter retrospective cohort studyOxygenation assessmentInitial antibiotic administrationRetrospective cohort studyCare performanceMedical record reviewHours of arrivalAcute care hospitalsLogistic regression analysisCohort studyCare hospitalImproved survivalRecord reviewHospital careMedicare patientsFrequent causePneumoniaPatientsFunctional Disability Before Myocardial Infarction in the Elderly as a Determinant of Infarction Severity and Postinfarction Mortality
Vaccarino V, Berkman LF, Mendes de Leon CF, Seeman TE, Horwitz RI, Krumholz HM. Functional Disability Before Myocardial Infarction in the Elderly as a Determinant of Infarction Severity and Postinfarction Mortality. JAMA Internal Medicine 1997, 157: 2196-2204. PMID: 9342996, DOI: 10.1001/archinte.1997.00440400046006.Peer-Reviewed Original ResearchConceptsMyocardial infarctionClinical severityFunctional disabilityElderly patientsDaily livingHigh mortalityAcute myocardial infarctionHigher clinical severityMore comorbiditiesPostinfarction mortalityHospital arrivalMI severityInfarction severityHospital treatmentHigh comorbidityRelative riskOutcome measuresCommon conditionPatientsTreatment interventionsMortalityOlder ageSeverity characteristicsSeverityConfidence intervals