2020
Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice
Li X, Zhang D, Vatner DF, Goedeke L, Hirabara SM, Zhang Y, Perry RJ, Shulman GI. Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 32584-32593. PMID: 33293421, PMCID: PMC7768680, DOI: 10.1073/pnas.1922169117.Peer-Reviewed Original ResearchConceptsEpididymal white adipose tissueInsulin resistanceAdiponectin treatmentAdipose tissueHigh-fat diet-induced insulin resistanceType 2 diabetes mellitusWhole-body insulin resistanceDiet-induced insulin resistanceSkeletal muscleEctopic lipid storageReverses insulin resistanceInsulin-mediated suppressionMuscle fatty acid oxidationEndogenous glucose productionMuscle insulin resistanceWhite adipose tissueLipoprotein lipase activityMuscle fat oxidationPKCε translocationInsulin-stimulated glucose uptakeFatty acid oxidationTAG uptakeDiabetes mellitusMuscle sensitivityAkt serine phosphorylation
1997
The Effect of Leptin Is Enhanced by Microinjection Into the Ventromedial Hypothalamus
Jacob R, Dziura J, Medwick M, Leone P, Caprio S, During M, Shulman G, Sherwin R. The Effect of Leptin Is Enhanced by Microinjection Into the Ventromedial Hypothalamus. Diabetes 1997, 46: 150-152. PMID: 8971096, DOI: 10.2337/diab.46.1.150.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamusFood intakeBody weightDistinct central nervous system regionsBrain regionsCentral nervous system regionsTwice-daily injectionsDorsal raphe nucleusSuppress food intakeEffects of leptinNervous system regionsRecombinant human leptinBody weight changesLeptin-induced effectsDaily food intakeBrain cannulaDorsal rapheLeptin administrationRaphe nucleusGuide cannulaMale ratsLateral ventricleSmall doseLeptinHuman leptin