1997
The Effect of Leptin Is Enhanced by Microinjection Into the Ventromedial Hypothalamus
Jacob R, Dziura J, Medwick M, Leone P, Caprio S, During M, Shulman G, Sherwin R. The Effect of Leptin Is Enhanced by Microinjection Into the Ventromedial Hypothalamus. Diabetes 1997, 46: 150-152. PMID: 8971096, DOI: 10.2337/diab.46.1.150.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamusFood intakeBody weightDistinct central nervous system regionsBrain regionsCentral nervous system regionsTwice-daily injectionsDorsal raphe nucleusSuppress food intakeEffects of leptinNervous system regionsRecombinant human leptinBody weight changesLeptin-induced effectsDaily food intakeBrain cannulaDorsal rapheLeptin administrationRaphe nucleusGuide cannulaMale ratsLateral ventricleSmall doseLeptinHuman leptin
1995
Local Ventromedial Hypothalamus Glucopenia Triggers Counterregulatory Hormone Release
Borg W, Sherwin R, During M, Borg M, Shulman G. Local Ventromedial Hypothalamus Glucopenia Triggers Counterregulatory Hormone Release. Diabetes 1995, 44: 180-184. PMID: 7859938, DOI: 10.2337/diab.44.2.180.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamusFrontal lobeMicrodialysis probeCounterregulatory hormone releaseCellular glucopeniaCounterregulatory hormonesCounterregulatory responsesPlasma glucagonPlasma glucoseLocal perfusionHormone releaseCerebral tissueStriking elevationControl groupGlucopeniaBrain tissueGlucopenic agentHypoglycemiaRatsTwofold increaseLobeTissueNorepinephrineHypothalamusEpinephrine