2020
Regulation of adipose tissue inflammation by interleukin 6
Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 2751-2760. PMID: 31980524, PMCID: PMC7022151, DOI: 10.1073/pnas.1920004117.Peer-Reviewed Original ResearchConceptsInterleukin-6Adipose tissue inflammationLow-grade inflammationIndividual cell typesMacrophage infiltrationInflammatory cytokinesTissue inflammationGlucose disposalImmune cellsIL6 productionMouse modelChronic stateAdipose tissueMyeloid cellsTissue infiltrationReceptor αConditional expressionCell typesOxidative metabolismOpposite actionsPhysiological regulationEnergy expenditureCanonical modeInflammationSpecific cells
2018
Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity
Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell Reports 2018, 24: 1085-1092.e6. PMID: 30067966, PMCID: PMC6223120, DOI: 10.1016/j.celrep.2018.06.112.Peer-Reviewed Original ResearchConceptsHigh-fat dietInsulin resistanceFood intakeMetabolic inflammationNucleobindin-2M2-like macrophage polarizationHigh-fat diet feedingWeight lossAdipose tissue macrophagesObesity-associated diseasesNesfatin-1Insulin sensitivityDiet feedingMacrophage polarizationNUCB2 proteinMyeloid cellsTissue macrophagesGlobal deletionClassical M1NUCB2NFκB-dependent mannerWeight gainSatietyIntakeAdiposity