2019
Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons
Park HA, Mnatsakanyan N, Broman K, Davis AU, May J, Licznerski P, Crowe-White KM, Lackey KH, Jonas EA. Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons. International Journal Of Molecular Sciences 2019, 21: 220. PMID: 31905614, PMCID: PMC6982044, DOI: 10.3390/ijms21010220.Peer-Reviewed Original ResearchConceptsPrimary hippocampal neuronsHippocampal neuronsReactive oxygen speciesMitochondrial dysfunctionBcl-xLMitochondrial membrane potentialMitochondrial functionProduction of ROSExcitotoxic conditionsGlutamate challengeNeuroprotective propertiesMembrane potentialNeuronal deathExcitotoxic stimulationBcl-xL levelsNeuronal survivalIntracellular ATP depletionMitochondrial reactive oxygen speciesB cellsImportant causeDysfunctionNeuronsROS productionATP depletionNeurite outgrowth
2018
Nutritional Regulators of Bcl-xL in the Brain
Park HA, Broman K, Stumpf A, Kazyak S, Jonas EA. Nutritional Regulators of Bcl-xL in the Brain. Molecules 2018, 23: 3019. PMID: 30463183, PMCID: PMC6278276, DOI: 10.3390/molecules23113019.Peer-Reviewed Original ResearchConceptsBcl-xLNormal brain developmentNeuroprotective propertiesBcl-xL expressionB cellsBrain developmentBcl-2 proteinAnti-apoptotic Bcl-2 proteinPathological processesSafe strategyToxic stimulationHuman subjectsMitochondrial functionRegulatory effectsBrainNutritional regulatorsDiseaseNeuronsPathology