2021
The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity
Kuchroo JR, Hafler DA, Sharpe AH, Lucca LE. The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity. Science Immunology 2021, 6: eabf4034. PMID: 34739340, DOI: 10.1126/sciimmunol.abf4034.Peer-Reviewed Original ResearchConceptsImmune-related adverse eventsPD-1 blockadeRegulatory T cell functionImmune checkpoint blockadeCheckpoint blockade immunotherapyT cell responsesT cell functionBlockade immunotherapyAdverse eventsAntitumor immunityCheckpoint blockadeCell responsesBlockadeCell functionAutoimmunityMechanistic featuresEdged swordImmunotherapyTumorsCancerImmunity
2004
Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis
Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis. Journal Of Experimental Medicine 2004, 199: 971-979. PMID: 15067033, PMCID: PMC2211881, DOI: 10.1084/jem.20031579.Peer-Reviewed Original ResearchConceptsRegulatory T cellsMultiple sclerosisT cellsRegulatory T cell functionActivity of murineSpontaneous autoimmune diseaseT cell functionSingle cell cloning experimentsPeripheral toleranceCell cloning experimentsAutoimmune diseasesPeripheral bloodInflammatory diseasesHealthy donorsHuman CD4Effector functionsNormal controlsPatientsFunctional suppressionCell functionSignificant decreaseSclerosisProtein peptidesDiseaseActive suppression
2002
Inhibition of Human CD4+CD25+high Regulatory T Cell Function
Baecher-Allan C, Viglietta V, Hafler DA. Inhibition of Human CD4+CD25+high Regulatory T Cell Function. The Journal Of Immunology 2002, 169: 6210-6217. PMID: 12444126, DOI: 10.4049/jimmunol.169.11.6210.Peer-Reviewed Original ResearchMeSH KeywordsAntigensCD4-Positive T-LymphocytesCoculture TechniquesCytokinesGlucocorticoid-Induced TNFR-Related ProteinHumansImmune ToleranceInterleukin-10Lymphocyte ActivationModels, ImmunologicalReceptors, Interleukin-2Receptors, Nerve Growth FactorReceptors, Tumor Necrosis FactorSignal TransductionT-Lymphocyte SubsetsTransforming Growth Factor betaConceptsAutoreactive T cellsT cellsRegulatory cellsRegulatory T cell functionInflammatory immune responseT cell functionStrength of stimulationPathologic responseInhibition of humanMicrobial AgsResponder cellsImmune responseEffector functionsTCR stimuliTime pointsCell functionTCR signalsPotent regulatorDifferential activationExtent of suppressionStimulationActivationCellsSuppressionStimuli