2016
Reorganization of brain connectivity in obesity
Geha P, Cecchi G, Constable R, Abdallah C, Small DM. Reorganization of brain connectivity in obesity. Human Brain Mapping 2016, 38: 1403-1420. PMID: 27859973, PMCID: PMC6866793, DOI: 10.1002/hbm.23462.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBrainBrain MappingEatingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMotionNeural PathwaysObesityOxygenConceptsGlobal brain connectivityDorsal attention networkPeripheral metabolic dysfunctionHum Brain MappSuperior parietal lobuleSomatomotor cortexMetabolic dysfunctionVentrolateral prefrontal cortexPremotor areasCaudate nucleusNeurocognitive impairmentObesityAnterior hippocampusVisual cortexBrain regionsParietal lobuleBrain functionPrefrontal cortexBrain connectivityMilkshake consumptionCortexFeeding decisionsBrain organizationInsulaHomeostatic state
2015
Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior
Kroemer NB, Sun X, Veldhuizen MG, Babbs AE, de Araujo IE, Small DM. Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior. NeuroImage 2015, 128: 273-283. PMID: 26724781, DOI: 10.1016/j.neuroimage.2015.12.031.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBody Mass IndexFeeding BehaviorFemaleHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNucleus AccumbensYoung AdultConceptsBrain responsesHigher body mass indexAd libitum food consumptionBody mass indexGreater weight lossNucleus Accumbens ResponseFunctional magnetic resonanceMilkshake receiptMass indexPlasma insulinPlasma glucoseMetabolic parametersDietary disinhibitionStriatal activityVariable response patternsWeight lossFood stimuliMetabolic responseSensory stimuliFood consumptionIntra-individual variationVariable responseMilkshakeMagnetic resonanceResponse patternsOpposing relationships of BMI with BOLD and dopamine D2/3 receptor binding potential in the dorsal striatum
Cosgrove KP, Veldhuizen MG, Sandiego CM, Morris ED, Small DM. Opposing relationships of BMI with BOLD and dopamine D2/3 receptor binding potential in the dorsal striatum. Synapse 2015, 69: 195-202. PMID: 25664726, PMCID: PMC4411955, DOI: 10.1002/syn.21809.Peer-Reviewed Original ResearchConceptsBody mass indexPalatable food consumptionDorsal striatumMass indexBOLD responseReceptor availabilityRelationship of BMIFood consumptionPET studiesMagnetic resonance imaging studyPositron emission tomography studyBlood oxygen level-dependent (BOLD) responseDopamine D2/3 receptorsHigh-fat dietDopamine receptor levelsEmission tomography studiesFMRI studyResonance imaging studyFunctional magnetic resonance imaging studyLevel-dependent responsesReliable inverse relationshipHealthy weightD2/3 receptorsStriatal circuitryFat diet
2014
The neural signature of satiation is associated with ghrelin response and triglyceride metabolism
Sun X, Veldhuizen MG, Wray AE, de Araujo IE, Sherwin RS, Sinha R, Small DM. The neural signature of satiation is associated with ghrelin response and triglyceride metabolism. Physiology & Behavior 2014, 136: 63-73. PMID: 24732416, PMCID: PMC4195817, DOI: 10.1016/j.physbeh.2014.04.017.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceBrainBrain MappingEatingFastingFemaleGhrelinHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleOxygenSatiationTasteTriglyceridesYoung AdultConceptsPalatable foodMeal terminationBrain responsesAd libitum mealPost-prandial reductionMedial orbitofrontal cortexDorsolateral prefrontal cortexGhrelin responseAcute changesFree fatty acidsPeripheral signalsTriglyceride metabolismBrain regionsBrain circuitsOrbitofrontal cortexPrefrontal cortexAmount of foodGhrelinMidbrainMilkshakeTriglyceridesCortexFatty acidsEnergy storesGreater attenuation
2013
Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity
Babbs RK, Sun X, Felsted J, Chouinard-Decorte F, Veldhuizen MG, Small DM. Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity. Physiology & Behavior 2013, 121: 103-111. PMID: 23562867, PMCID: PMC3731396, DOI: 10.1016/j.physbeh.2013.03.025.Peer-Reviewed Original ResearchMeSH KeywordsAdultBody Mass IndexCaudate NucleusFemaleFoodFood PreferencesHumansImage Processing, Computer-AssistedImpulsive BehaviorMaleOverweightOxygenRegression AnalysisRewardSelf ReportTasteYoung AdultConceptsBody mass indexCaudate responseMass indexCaudate nucleusBrain responsesHigher body mass indexWeight gainHealthy weight subjectsTasteless control solutionEnergy-dense foodsSelf-reported impulsivityWeight subjectsNegative associationVentral putamenDorsal striatumFood rewardDense foodsSignificant associationInverse correlationMilkshakeOverweightGreater impulsivityMeasures of impulsivityGreater responseAssociation
2012
Food and drug cues activate similar brain regions: A meta-analysis of functional MRI studies
Tang D, Fellows L, Small D, Dagher A. Food and drug cues activate similar brain regions: A meta-analysis of functional MRI studies. Physiology & Behavior 2012, 106: 317-324. PMID: 22450260, DOI: 10.1016/j.physbeh.2012.03.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingCuesFoodHumansImage Processing, Computer-AssistedLikelihood FunctionsMagnetic Resonance ImagingOxygenPhotic StimulationPubMedSmokingConceptsSmoking cuesOrbital frontal cortexNeutral cuesFood cuesVisual foodBlood oxygen level-dependent (BOLD) responseBrain regionsSimilar brain regionsBilateral orbital frontal cortexActivation likelihood estimationFrontal cortexFunctional MRI studyLevel-dependent responsesBrain imaging studiesNeuro-imaging studiesDrug cuesImaging studiesInsula activationSubjective cravingConditioned cuesIncentive salienceBrain responsesBilateral insulaBrain networksLeft amygdala
2011
The Anterior Insular Cortex Represents Breaches of Taste Identity Expectation
Veldhuizen MG, Douglas D, Aschenbrenner K, Gitelman DR, Small DM. The Anterior Insular Cortex Represents Breaches of Taste Identity Expectation. Journal Of Neuroscience 2011, 31: 14735-14744. PMID: 21994389, PMCID: PMC3221736, DOI: 10.1523/jneurosci.1502-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAttentionBrain MappingCuesFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingOxygenPain MeasurementReaction TimeSomatosensory CortexSucroseTasteTaste PerceptionYoung AdultYouth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food
Stice E, Yokum S, Burger KS, Epstein LH, Small DM. Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food. Journal Of Neuroscience 2011, 31: 4360-4366. PMID: 21430137, PMCID: PMC3260083, DOI: 10.1523/jneurosci.6604-10.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrain MappingCorpus StriatumCuesData Interpretation, StatisticalDeglutitionFemaleFoodHumansHyperphagiaImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleObesityOxygenRewardRiskSomatosensory CortexConceptsNormal weight humansObese humansStriatal responsesFood intakeOrbitofrontal cortexDopamine signalingWeight gainInitial vulnerability factorsGenetic riskStriatal D2 receptorsMonetary rewardsNormal-weight adolescentsPalatable food intakeD2 receptor densityD2 receptorsHigh-risk youthParietal operculumReceptor densitySomatosensory regionsPalatable foodFoods contributesFrontal operculumReward circuitryReduced dopamineObesity
2010
Genetically Determined Differences in Brain Response to a Primary Food Reward
Felsted JA, Ren X, Chouinard-Decorte F, Small DM. Genetically Determined Differences in Brain Response to a Primary Food Reward. Journal Of Neuroscience 2010, 30: 2428-2432. PMID: 20164326, PMCID: PMC2831082, DOI: 10.1523/jneurosci.5483-09.2010.Peer-Reviewed Original ResearchConceptsBrain responsesPrimary food rewardFunctional magnetic resonanceTaqIA A1 alleleOrbital frontal cortexReward driveIndividual differencesNeural responsesFuture weight gainFood rewardPalatable foodNeuroimaging techniquesPerceptual responsesBiological underpinningsIndividual factorsFrontal cortexImpulsivityDiminished dopamineSimilar ratingsFood reinforcementRewardSpecific associationNeurophysiologyMilkshakeBody mass index
2005
Odor/taste integration and the perception of flavor
Small DM, Prescott J. Odor/taste integration and the perception of flavor. Experimental Brain Research 2005, 166: 345-357. PMID: 16028032, DOI: 10.1007/s00221-005-2376-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainFoodHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingModels, NeurologicalOdorantsSmellTasteConceptsFlavor perceptionUnitary perceptionCross-modal sensory interactionsSensory inputVentral lateral prefrontal cortexParticular sensory characteristicsLateral prefrontal cortexPosterior parietal cortexMultiple sensory inputsAnterior cingulate cortexPerception of flavorAttentional allocationHeteromodal regionsNeural processesAnterior insulaFlavor processingFrontal operculumOrbitofrontal cortexPrefrontal cortexCingulate cortexFlavor of foodParietal cortexNeurophysiological studiesPerceptionSensory interaction
2003
Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers
Small DM, Jones-Gotman M, Dagher A. Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. NeuroImage 2003, 19: 1709-1715. PMID: 12948725, DOI: 10.1016/s1053-8119(03)00253-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingCarbon RadioisotopesCaudate NucleusCorpus StriatumDopamineEatingFemaleHumansHungerImage Processing, Computer-AssistedMalePutamenRacloprideSatiety ResponseTasteTomography, Emission-ComputedConceptsDopamine releasePositron emission tomography scanEmission tomography scanHealthy human volunteersHunger/fullnessFavorite mealAmount of dopamineDorsal putamenStriatum correlatesTomography scanHealthy subjectsCaudate nucleusPleasantness ratingsHuman volunteersVentral striatumScan subjectsStriatumHungry stateSignificant reductionSignificant changesPET dataMealParametric mapsSubjectsCorrelatesDissociation of Neural Representation of Intensity and Affective Valuation in Human Gustation
Small DM, Gregory MD, Mak YE, Gitelman D, Mesulam MM, Parrish T. Dissociation of Neural Representation of Intensity and Affective Valuation in Human Gustation. Neuron 2003, 39: 701-711. PMID: 12925283, DOI: 10.1016/s0896-6273(03)00467-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaBrainBrain MappingEmotionsFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleStimulation, ChemicalTaste