2021
Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation
Bond MJ, Crews CM. Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation. RSC Chemical Biology 2021, 2: 725-742. PMID: 34212149, PMCID: PMC8190915, DOI: 10.1039/d1cb00011j.Peer-Reviewed Original Research
2007
Life on the edge: Therapeutic uses of cytotoxic natural products
Crews C, Leuenroth S, Okuhara D, Shotwell J, Markowitz G, Yu Z, Somlo S. Life on the edge: Therapeutic uses of cytotoxic natural products. The FASEB Journal 2007, 21: a38-a38. DOI: 10.1096/fasebj.21.5.a38-b.Peer-Reviewed Original ResearchAutosomal dominant polycystic kidney diseaseCytotoxic concentrationsPhase I clinical trialLei Gong TengDominant polycystic kidney diseasePolycystic kidney diseaseKidney diseaseChinese medicinal herbsClinical trialsMurine modelCyst formationClinical potentialTriptolideTherapeutic usesDrug developmentMedicinal herbsCytotoxic activityCalcium channel polycystin-2Cytostatic signalsPolycystin-2Cytotoxic compoundsNatural products