Featured Publications
Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis
Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 2019, 4: e127456. PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisAcute kidney diseasePrebiopsy diagnosisKidney biopsyKidney diseaseIL-9AIN diagnosisUrine TNFInterstitial nephritisSpecific T cell subsetsAcute tubular injuryDiabetic kidney diseaseIL-9 levelsTNF-α levelsT cell subsetsAddition of biomarkersPlasma cytokinesCytokine levelsTubular injuryHighest quartileMultivariable analysisCell subsetsUrinary TNFBlood eosinophilsGlomerular disease
2019
Differentiating Acute Interstitial Nephritis from Acute Tubular Injury: A Challenge for Clinicians
Moledina DG, Parikh CR. Differentiating Acute Interstitial Nephritis from Acute Tubular Injury: A Challenge for Clinicians. Nephron 2019, 143: 211-216. PMID: 31203275, PMCID: PMC6821567, DOI: 10.1159/000501207.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute interstitial nephritisAcute tubular injuryAcute kidney injuryUrine TNFTubular injuryInterstitial nephritisClinical featuresHistological diagnosisInterleukin-9Novel biomarkersClinical practiceChronic kidney diseaseProspective cohort studyHigh-risk populationDisease-specific therapiesCourse of careImmunosuppressive therapyKidney injuryCohort studyKidney biopsyKidney diseasePlasma levelsKidney fibrosisInter-rater variabilityLaboratory assessment
2018
Kidney Biopsy–Related Complications in Hospitalized Patients with Acute Kidney Disease
Moledina DG, Luciano RL, Kukova L, Chan L, Saha A, Nadkarni G, Alfano S, Wilson FP, Perazella MA, Parikh CR. Kidney Biopsy–Related Complications in Hospitalized Patients with Acute Kidney Disease. Clinical Journal Of The American Society Of Nephrology 2018, 13: 1633-1640. PMID: 30348813, PMCID: PMC6237071, DOI: 10.2215/cjn.04910418.Peer-Reviewed Original ResearchConceptsAcute kidney diseaseBiopsy-related complicationsLow platelet countHospitalized patientsNonhospitalized patientsKidney biopsyKidney diseasePlatelet countHigher BUNFemale sexRisk factorsLarge-sized hematomaStage 1 AKIRate of complicationsProcedure-related bleedingLarger needle gaugeAbdominal ultrasonographyBiopsy cohortBlood transfusionAngiographic interventionMultivariable analysisPostbiopsy complicationsMultivariable associationsHigh riskTransfusion
2017
Drug-Induced Acute Interstitial Nephritis
Moledina DG, Perazella MA. Drug-Induced Acute Interstitial Nephritis. Clinical Journal Of The American Society Of Nephrology 2017, 12: 2046-2049. PMID: 28893923, PMCID: PMC5718279, DOI: 10.2215/cjn.07630717.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements