Acute Kidney Injury in Marathon Runners

Overview

Participation in marathons has gained popularity in the United States with up to 1,100 marathons and 507, 600 finishers. We have shown that the majority of runners develop transient acute kidney injury (AKI) with urine sediments and novel kidney injury biomarkers which reveal intrinsic tubular damage. The mechanism behind runner AKI has yet to be investigated.

Currently, we have an enrollment of 45 runners who have participated in the Hartford, Connecticut marathon in years 2015 and 2017. We collected blood, urine, and sweat samples to measure both conventional and novel markers involved in injury, repair and regulatory responses, in order to better understand the mechanism behind the transient, yet severe, AKI in runners. We also collected extensive training histories, as well as detailed intake/output histories through questionnaires given to runners before and after the races.

Contact Information

For more information, or if you are interested in collaborating on this study, please contact Dr. Sherry Mansour

Leadership

Sherry Mansour, MD, MS
Assistant Professor; Wellness Director, Internal Medicine
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Chirag Parikh, MD, PhD, FACP
Professor Adjunct
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Collaborators

Thomas G. Martin, PhD
Associate Professor of Biomedical Sciences, Quinnipiac University

Rachel W. Pata, DPT, CCS
Clinical Associate Professor of Physical Therapy, Quinnipiac University

Karen M. Myrick, DNP, APRN
Associate Professor of Nursing, Quinnipiac University

Publications

Kidney Injury and Repair Biomarkers in Marathon Runners.Mansour SG, Verma G, Pata RW, Martin TG, Perazella MA, Parikh CR. Am J Kidney Dis. 2017 Aug; 2017 Mar 28. PMID: 28363731.