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Alfred Kaye, MD, PhD

Assistant Professor of Psychiatry

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Alfred Kaye, MD, PhD


Dr. Kaye is an Assistant Professor of Psychiatry, using a combination of circuit and computational approaches to understand adaptations to the danger in the environment and how those adaptations underlie PTSD. He graduated from the University of California M.D., Ph.D. program, where he used two-photon imaging and computational modeling to understand the organization of visual motion processing. Then, he joined the psychiatry residency at Yale, where he worked in Alex Kwan's lab on using calcium and neurotransmitter imaging to understand how arousal states change after stress, and also developed computational models of PTSD.

The lab will focus on understanding how neuromodulatory circuits reprogram one another to create adaptive responses to traumatic experiences. Underlying this idea is the central problem of developing a mechanistic and functional understanding of stress and anxiety. The lab uses microendoscope and two-photon imaging of calcium and neurotransmitter sensors, large-scale electrophysiology (Neuropixels), computational analysis of behavior (DeepLabCut), and single cell transcriptomics to understand this problem.

Education & Training

  • Research Fellow
    Veterans Administration National Center for PTSD (2020)
  • Non Degree Program
    VA National Center for PTSD, Research Fellow (2020)
  • Resident
    Yale University (2018)
  • Chief Resident
    Yale University (2018)
  • MD
    University of California, San Diego (2014)
  • PhD
    University of California, San Diego (2013)


  • Board Certification
    ABPN, Psychiatry (2021)

Honors & Recognition

AwardAwarding OrganizationDate
Mentored Clinical Scientist Research Career Development Award (K08)National Institute of Mental Health2020
Pilot Grant Research Award10X Genomics2020
The Seymour L. Lustman Award for Psychiatric ResearchYale University2019
NARSD Young Investigator AwardBrain and Behavior Research Foundation2019
Outstanding Resident Award ProgramNational Institute of Mental Health2017
National Research Service Award (F30 NRSA)National Institute of Deafness and Communication Disorders2011

Professional Service

National Science FoundationAd-hoc reviewer2021 - 2022

Departments & Organizations