MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)
Volunteers
Health Professionals
What is the purpose of this trial?
This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine over time. PCI is radiation therapy that is delivered to the brain in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. Monitoring with MRI scans alone (delaying radiation until the actual spread of the cancer) may be at least as good as the combination of PCI with MRI scans.
Help Us Discover!
You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call 877.978.8343 for more information.
Principal Investigator
Sub-Investigators
- Abhijit Patel, MD, PhD
- Allison Campbell, MD, PhD
- Anca Bulgaru, MD
- Andrea Brennan
- Anne Chiang, MD, PhD
- Armand Russo, MD
- Benjamin Newton, MD
- Beverly Drucker, MD, PhD
- Bruce A. McGibbon, MD
- Carrie Fijal, MSN, AGPCNP-BC, OCN
- Catherine Wei, MD
- Christin A. Knowlton, MD, MA
- D. Barry Boyd, MD, MS
- David Witt, MD
- Elan Gorshein, DO, JD, MPH
- Emily Kopas, APRN, OCN
- Francesca Montanari, MD
- Frederick Wilson, MD, PhD
- Harold Tara Jr, MD
- James Laird, MD
- Jane Kanowitz, MD
- Jason Haldas, MD
- Jeremy Kortmansky, MD
- Johanna LaSala, MD
- John Glendening
- Justin Persico, MD
- Kathleen Fenn, MD
- Kevin Du, MD, PhD, MSCI
- Kimberly L. Johung, MD, PhD
- Kristen Hoxie
- Larisa Fleysher
- M. Sung Lee, MD
- Marianne Davies, NP, DNP, MSN, BSN
- Melissa Rasar Young, MD, PhD
- Michael Cohenuram, MD
- Nadine Housri, MD
- Neal Fischbach, MD
- Nicholas Blondin, MD
- Ranjit S. Bindra, MD, PhD
- Renee Moye
- Robert Legare, MD
- Roy S. Herbst, MD, PhD
- Sarah Carlson
- Sarah Goldberg, MD, MPH
- Scott Gettinger, MD
- So Yeon Kim, MD
- Stephen Lattanzi, MD
- Su Hsien Lim, MD
- Thomas Hayman, MD, PhD
- Vanna Dest
- Virginia Syombathy
- Wajih Kidwai, MD, FACP
- Yi An, MD
- Last Updated09/24/2024
- Study HIC#2000027403