2022
An HPA-1a–positive platelet–depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo–controlled, single-center, phase 1/2 proof-of-concept study
Geisen C, Kjaer M, Fleck E, Skogen B, Armstrong R, Behrens F, Bhagwagar Z, Braeuninger S, Mortberg A, Olsen K, Gastón Schäfer S, Walter C, Seifried E, Wikman A, Kjeldsen-Kragh J, Koehm M. An HPA-1a–positive platelet–depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo–controlled, single-center, phase 1/2 proof-of-concept study. Journal Of Thrombosis And Haemostasis 2022, 21: 838-849. PMID: 36696185, DOI: 10.1016/j.jtha.2022.11.041.Peer-Reviewed Original ResearchConceptsFetal/Neonatal Alloimmune ThrombocytopeniaNeonatal alloimmune thrombocytopeniaHPA-1aAlloimmune thrombocytopeniaHuman platelet antigen 1aTreatment-emergent adverse eventsPlacebo 1 hourHPA-1a antibodiesFNAIT casesHyperimmune IgGPrimary endpointAdverse eventsFetus/Healthy menSingle doseAntigen 1aHLA-A2Concept studyCohort 1PlaceboFlow cytometryThrombocytopeniaPlateletsAdministrationWeeks
2019
Lithium for acute mania
Bhagwagar Z, Goodwin G, Geddes J. Lithium for acute mania. Cochrane Database Of Systematic Reviews 2019, 2019 PMCID: PMC6524414, DOI: 10.1002/14651858.cd004048.pub3.Peer-Reviewed Original Research
2012
P2‐412: A comparison of hippocampal atrophy algorithms to select outcome measures for clinical trials in mild‐to‐moderate Alzheimer's disease
Burns L, Rueckert D, Bhagwagar Z, Donohue M, Wolz R, Tiller J, Soares H, l'Italien G, Coric V, Hayes W, Fox N, Berman R. P2‐412: A comparison of hippocampal atrophy algorithms to select outcome measures for clinical trials in mild‐to‐moderate Alzheimer's disease. Alzheimer's & Dementia 2012, 8: p408-p408. DOI: 10.1016/j.jalz.2012.05.2037.Peer-Reviewed Original ResearchP2‐423: vMRI and whole‐brain volume in patients with mild‐to‐moderate Alzheimer's disease
Budd D, Nalysnyk L, Fahrbach K, Bhagwagar Z, Berman R, Burns L, l'Italien G. P2‐423: vMRI and whole‐brain volume in patients with mild‐to‐moderate Alzheimer's disease. Alzheimer's & Dementia 2012, 8: p411-p412. DOI: 10.1016/j.jalz.2012.05.2048.Peer-Reviewed Original ResearchP2‐422: vMRI and hippocampal volume in patients with suspected predementia Alzheimer's disease
Budd D, Nalysnyk L, Fahrbach K, Bhagwagar Z, Berman R, Burns L, l'Italien G. P2‐422: vMRI and hippocampal volume in patients with suspected predementia Alzheimer's disease. Alzheimer's & Dementia 2012, 8: p411-p411. DOI: 10.1016/j.jalz.2012.05.2047.Peer-Reviewed Original ResearchAntidepressants
Bhagwagar Z, Heninger G. Antidepressants. 2012, 1185-1198. DOI: 10.1093/med/9780199696758.003.0153.Peer-Reviewed Original ResearchWorld Health Organization Global BurdenMajor public health problemPharmacology of antidepressantsLargest causeTreatment of depressionMajor depressive disorderPublic health problemAbstract Major depressive disorderImportance of depressionRecurrent illnessDepressive disorderPrimary treatmentAntidepressant drugsGlobal burdenHigh riskHealth problemsDepressionAntidepressantsDrugsPatientsDepressed individualsSelective useCliniciansBurdenDisease
2011
Abnormal prefrontal activity subserving attentional control of emotion in remitted depressed patients during a working memory task with emotional distracters
Kerestes R, Ladouceur CD, Meda S, Nathan PJ, Blumberg HP, Maloney K, Ruf B, Saricicek A, Pearlson GD, Bhagwagar Z, Phillips ML. Abnormal prefrontal activity subserving attentional control of emotion in remitted depressed patients during a working memory task with emotional distracters. Psychological Medicine 2011, 42: 29-40. PMID: 21733287, DOI: 10.1017/s0033291711001097.Peer-Reviewed Original ResearchConceptsVentrolateral prefrontal cortexNegative emotional informationFunctional magnetic resonance imagingEmotional distractersAttentional controlEmotional informationMemory taskMemory loadEmotional Face N-Back (EFNBACK) taskOrbitofrontal cortexNegative emotional distractersN-back taskInterface of cognitionAccurate task performanceKey neural circuitsBlood oxygen level-dependent functional magnetic resonance imagingRMDD patientsLevel-dependent functional magnetic resonance imagingAttentional biasesFacial emotionsEmotion processingDepressed patientsDistracter stimuliTrait-like abnormalitiesRight DLPFC
2010
Increased peripheral blood expression of electron transport chain genes in bipolar depression
Beech RD, Lowthert L, Leffert JJ, Mason PN, Taylor MM, Umlauf S, Lin A, Lee JY, Maloney K, Muralidharan A, Lorberg B, Zhao H, Newton SS, Mane S, Epperson CN, Sinha R, Blumberg H, Bhagwagar Z. Increased peripheral blood expression of electron transport chain genes in bipolar depression. Bipolar Disorders 2010, 12: 813-824. PMID: 21176028, PMCID: PMC3076072, DOI: 10.1111/j.1399-5618.2010.00882.x.Peer-Reviewed Original ResearchConceptsBipolar disorderBipolar depressionPeripheral bloodDepressed subjectsGeneGo MetaCore softwarePeripheral blood expressionHealthy control subjectsReal-time reverse transcription-polymerase chain reactionEffects of medicationReverse transcription-polymerase chain reactionQuantitative real-time reverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMitochondrial electron transport chainControl subjectsPolymerase chain reactionUnmedicated subjectsHealthy controlsBlood expressionBPD subjectsSpecific genetic pathwaysElectron transport chain genesMetaCore softwareA totalAltered expressionQRT-PCRLevetiracetam in the management of bipolar depression: a randomized, double-blind, placebo-controlled trial.
Saricicek A, Maloney K, Muralidharan A, Ruf B, Blumberg HP, Sanacora G, Lorberg B, Pittman B, Bhagwagar Z. Levetiracetam in the management of bipolar depression: a randomized, double-blind, placebo-controlled trial. The Journal Of Clinical Psychiatry 2010, 72: 744-50. PMID: 21034692, DOI: 10.4088/jcp.09m05659gre.Peer-Reviewed Original ResearchConceptsDepression Rating ScaleRating ScaleMean changeWeek 6Clinical Global Impression-Bipolar Version ScaleBipolar disorderHamilton Depression Rating Scale scoresMontgomery-Åsberg Depression Rating ScalePlacebo-controlled clinical trialDepression Rating Scale scoresHamilton Depression Rating ScaleYoung Mania Rating ScaleAdjunctive levetiracetam therapyLevetiracetam adjunctive therapySecondary efficacy assessmentsBipolar disorder type IPlacebo-controlled trialHamilton Anxiety Rating ScalePrimary efficacy measureSecondary outcome measuresMajor depressive episodeRating Scale scoresMania Rating ScaleShort-term treatmentSignificant differencesThe Relationship Between Mood, Stress, and Tobacco Smoking
Walderhaug E, Cosgrove K, Bhagwagar Z, Neumeister A. The Relationship Between Mood, Stress, and Tobacco Smoking. 2010, 147-161. DOI: 10.1007/978-1-4419-6373-4_10.Peer-Reviewed Original ResearchTobacco smokingPrimary addictive substancePositron emission tomographySingle photon emissionNicotine sharesTobacco smokeNicotine dependenceNicotine addictionHealthy peopleAbuse potentialEmission tomographyBehavioral effectsAnxiety disordersAddictive substancesSmokingHigh rateNicotineMolecular imagingMoodTomographyPsychostimulantsIndividualsNeurotransmitter Systems in Bipolar Disorder
Nakic M, Krystal J, Bhagwagar Z. Neurotransmitter Systems in Bipolar Disorder. 2010, 210-227. DOI: 10.1002/9780470661277.ch16.Peer-Reviewed Original ResearchAssociation between serotonin transporter binding, physiological and environmental factors in healthy male subjects
Comley R, Miller S, Murthy V, Bhagwagar Z, Turner D, Peers P, Riedel W, Grasby P, Rabiner E. Association between serotonin transporter binding, physiological and environmental factors in healthy male subjects. NeuroImage 2010, 52: s93-s94. DOI: 10.1016/j.neuroimage.2010.04.075.Peer-Reviewed Original ResearchAntidepressant Response and the Serotonin Transporter Gene-Linked Polymorphic Region
Taylor MJ, Sen S, Bhagwagar Z. Antidepressant Response and the Serotonin Transporter Gene-Linked Polymorphic Region. Biological Psychiatry 2010, 68: 536-543. PMID: 20615496, PMCID: PMC2929304, DOI: 10.1016/j.biopsych.2010.04.034.Peer-Reviewed Original ResearchP1‐387: Mild to moderate Alzheimer's disease (AD) clinical trials: The role of hippocampal atrophy as an inclusion criterion
Risinger R, Berman R, Coric V, Han J, Kaplita S, Burns L, Bhagwagar Z, Hill D, Wolz R, Rueckert D, Feldman H. P1‐387: Mild to moderate Alzheimer's disease (AD) clinical trials: The role of hippocampal atrophy as an inclusion criterion. Alzheimer's & Dementia 2010, 6: s285-s286. DOI: 10.1016/j.jalz.2010.05.941.Peer-Reviewed Original ResearchDiminished center-surround inhibition in patients with a history of depression
Golomb J, Ruf B, Beck J, Saricicek A, Hu J, Chun M, Bhagwagar Z. Diminished center-surround inhibition in patients with a history of depression. Journal Of Vision 2010, 8: 1029-1029. DOI: 10.1167/8.6.1029.Peer-Reviewed Original ResearchP.1.025 Molecular imaging of beta-2 subunit containing nicotinic acetylcholine receptors in major depressive disorder
Saricicek A, Esterlis I, Ruf B, Maloney K, Muralidharan A, Seibyl J, Tamagnan G, Bois F, Staley J, Bhagwagar Z. P.1.025 Molecular imaging of beta-2 subunit containing nicotinic acetylcholine receptors in major depressive disorder. European Neuropsychopharmacology 2010, 20: s22. DOI: 10.1016/s0924-977x(10)70027-4.Peer-Reviewed Original Research
2009
Enhanced Visual Motion Perception in Major Depressive Disorder
Golomb JD, McDavitt JR, Ruf BM, Chen JI, Saricicek A, Maloney KH, Hu J, Chun MM, Bhagwagar Z. Enhanced Visual Motion Perception in Major Depressive Disorder. Journal Of Neuroscience 2009, 29: 9072-9077. PMID: 19605644, PMCID: PMC2772577, DOI: 10.1523/jneurosci.1003-09.2009.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceContrast SensitivityDepressive Disorder, MajorDiscrimination LearningDiscrimination, PsychologicalHumansMotion PerceptionNeuropsychological TestsOrientationPattern Recognition, VisualPhotic StimulationPsychophysicsReaction TimeSensory ThresholdsVisual AcuityYoung AdultConceptsSpatial suppressionMotion perceptionLarge high-contrast stimuliMotion discrimination taskVisual motion perceptionMajor depressive disorderGreater lifetime durationHigh-contrast stimuliPerceptual discriminationHealthy young adultsVisual processingDiscrimination taskTime of testingTrait vulnerabilityPsychophysical performanceCounterintuitive hypothesisEndophenotypic markerVisual systemProcessing tasksMood symptomsOccipital cortexDepressive disorderYoung adultsVisual pathwayCortical levelA Novel Paradigm for Examining the Interfering Effects of Emotional Distracters During a Working Memory Task: A Functional Magnetic Resonance Imaging (fMRI) Study
Kerestes R, Ladouceur C, Meda S, Blumberg H, Nathan P, Maloney K, Ruf B, Saricicek A, Hu J, Pearlson G, Bhagwagar Z, Phillips M. A Novel Paradigm for Examining the Interfering Effects of Emotional Distracters During a Working Memory Task: A Functional Magnetic Resonance Imaging (fMRI) Study. NeuroImage 2009, 47: s191. DOI: 10.1016/s1053-8119(09)72145-7.Peer-Reviewed Original ResearchNMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans
Driesen N, McCarthy G, Bhagwagar Z, Calhoun V, D'Souza D, Holub J, Morgan P, Krystal J. NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans. NeuroImage 2009, 47: s145. DOI: 10.1016/s1053-8119(09)71458-2.Peer-Reviewed Original Research
2008
Drs. Ghaznavi and Bhagwagar Reply
GHAZNAVI S, BHAGWAGAR Z. Drs. Ghaznavi and Bhagwagar Reply. American Journal Of Psychiatry 2008, 165: 1611-1612. DOI: 10.1176/appi.ajp.2008.08071105r.Peer-Reviewed Original Research