Featured Publications
Oncogene-like addiction to aneuploidy in human cancers
Girish V, Lakhani A, Thompson S, Scaduto C, Brown L, Hagenson R, Sausville E, Mendelson B, Kandikuppa P, Lukow D, Yuan M, Stevens E, Lee S, Schukken K, Akalu S, Vasudevan A, Zou C, Salovska B, Li W, Smith J, Taylor A, Martienssen R, Liu Y, Sun R, Sheltzer J. Oncogene-like addiction to aneuploidy in human cancers. Science 2023, 381: eadg4521. PMID: 37410869, PMCID: PMC10753973, DOI: 10.1126/science.adg4521.Peer-Reviewed Original Research
2024
The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells
Liao X, Li W, Zhou H, Rajendran B, Li A, Ren J, Luan Y, Calderwood D, Turk B, Tang W, Liu Y, Wu D. The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells. Nature Communications 2024, 15: 603. PMID: 38242867, PMCID: PMC10798966, DOI: 10.1038/s41467-024-44885-0.Peer-Reviewed Original ResearchConceptsCD8+ T cellsT cellsCancer immunotherapyMouse CD8+ T cellsAnti-tumor immunityTumor growth inhibition abilityAnti-tumor effectsInhibition of neddylationCD8Effector functionsTCR stimulationIL2 signalingCentral signaling pathwaysCore signaling pathwaysEffector activityNegative regulatory mechanismsTranslational implicationsImmunotherapyGrowth inhibition abilityCytokine signalingTCRProteomic alterationsSignaling pathwayCancerCRISPR-based screens
2017
Comparison of targeted proteomics approaches for detecting and quantifying proteins derived from human cancer tissues
Faktor J, Sucha R, Paralova V, Liu Y, Bouchal P. Comparison of targeted proteomics approaches for detecting and quantifying proteins derived from human cancer tissues. Proteomics 2017, 17 PMID: 27966270, DOI: 10.1002/pmic.201600323.Peer-Reviewed Original ResearchMeSH KeywordsHumansLimit of DetectionMass SpectrometryNeoplasmsProteinsProteomicsSignal-To-Noise RatioConceptsDifferent clinical-pathological characteristicsClinical pathological characteristicsHuman cancer tissuesClinical studiesCancer tissuesBreast tumorsTumor tissueCoefficient of varianceNumerous conditionsCancer researchMass spectrometry-based proteomic approachMultiple protein analytesProteomic approachTissueSequential window acquisition
2016
Image-based computational quantification and visualization of genetic alterations and tumour heterogeneity
Zhong Q, Rüschoff JH, Guo T, Gabrani M, Schüffler PJ, Rechsteiner M, Liu Y, Fuchs TJ, Rupp NJ, Fankhauser C, Buhmann JM, Perner S, Poyet C, Blattner M, Soldini D, Moch H, Rubin MA, Noske A, Rüschoff J, Haffner MC, Jochum W, Wild PJ. Image-based computational quantification and visualization of genetic alterations and tumour heterogeneity. Scientific Reports 2016, 6: 24146. PMID: 27052161, PMCID: PMC4823793, DOI: 10.1038/srep24146.Peer-Reviewed Original ResearchAgedComputational BiologyDNA Copy Number VariationsEndometrial NeoplasmsFemaleGenetic HeterogeneityGenetic Predisposition to DiseaseHumansImmunohistochemistryIn Situ Hybridization, FluorescenceKaplan-Meier EstimateMaleMiddle AgedMutationNeoplasm StagingNeoplasmsOvarian NeoplasmsProstatic NeoplasmsPTEN PhosphohydrolaseReceptor, ErbB-2Stomach Neoplasms
2013
Mass spectrometric protein maps for biomarker discovery and clinical research
Liu Y, Hüttenhain R, Collins B, Aebersold R. Mass spectrometric protein maps for biomarker discovery and clinical research. Expert Review Of Molecular Diagnostics 2013, 13: 811-825. PMID: 24138574, PMCID: PMC3833812, DOI: 10.1586/14737159.2013.845089.Peer-Reviewed Original Research