Featured Publications
Integration site–dependent HIV-1 promoter activity shapes host chromatin conformation
Collora J, Ho Y. Integration site–dependent HIV-1 promoter activity shapes host chromatin conformation. Genome Research 2023, 33: 891-906. PMID: 37295842, PMCID: PMC10519397, DOI: 10.1101/gr.277698.123.Peer-Reviewed Original ResearchInhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen
Pedersen SF, Collora JA, Kim RN, Yang K, Razmi A, Catalano AA, Yeh YJ, Mounzer K, Tebas P, Montaner LJ, Ho YC. Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen. Journal Of Virology 2022, 96: e00577-22. PMID: 35730977, PMCID: PMC9278143, DOI: 10.1128/jvi.00577-22.Peer-Reviewed Original ResearchConceptsHIV-1-infected cellsHIV-1 reactivationT cell clonesHIV-1HIV-1 protein expressionAntiretroviral therapyDrug treatmentProtein expressionInfected cellsInfected individualsHIV-1-infected individualsCell clonesEffective antiretroviral therapyHIV-1 cureLong-term therapyHIV-1 gene expressionHIV-1 persistenceHIV-1 provirusHIV-1 transcriptionImmune cell killingNovel therapeutic targetCell deathLatent reservoirImmune cellsT cells
2022
Interferon opens up: HIV-induced inflammation reconfigures 3D chromatin conformation and affects where HIV integrates
Wei Y, Ho Y. Interferon opens up: HIV-induced inflammation reconfigures 3D chromatin conformation and affects where HIV integrates. Molecular Cell 2022, 82: 4585-4587. PMID: 36525953, PMCID: PMC9925257, DOI: 10.1016/j.molcel.2022.11.013.Peer-Reviewed Original ResearchThe loud minority: Transcriptionally active HIV-1-infected cells survive, proliferate, and persist
Collora JA, Ho YC. The loud minority: Transcriptionally active HIV-1-infected cells survive, proliferate, and persist. Cell 2022, 185: 227-229. PMID: 35063069, PMCID: PMC9195179, DOI: 10.1016/j.cell.2021.12.038.Peer-Reviewed Original Research