WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury
Wang Y, Cui C, Zhao W, Tian X, Liu P, Wei L, Zhu Z, Liu M, Fu R, Jia L. WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury. Immunobiology 2024, 229: 152832. PMID: 38943814, DOI: 10.1016/j.imbio.2024.152832.Peer-Reviewed Original ResearchAcute kidney injuryAcute tubular injuryLPS-induced acute kidney injuryHuman kidney 2Wip1 activityKidney injuryRenal tubulesUnilateral ischemia-reperfusion injurySepsis-associated acute kidney injuryRenal tubules of patientsHK2 cellsProtein levelsInduce acute injuryProximal renal tubulesWild-type p53-induced phosphatase 1Ischemia-reperfusion injuryPhosphorylation of p38 MAPKGSDMD-NHuman kidney-2 cellsSingle-cell sequencingPPM1D mRNAPhospho-p38 MAPKTubular injuryWip1 inhibitorScRNA-seq