DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways
Li K, Zhang Y, Zhao W, Wang R, Li Y, Wei L, Wang L, Chen X, Chen Z, Liu P, Nie N, Tian X, Fu R. DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways. Toxicology Letters 2024, 395: 1-10. PMID: 38458339, DOI: 10.1016/j.toxlet.2024.03.001.Peer-Reviewed Original ResearchHuman mesangial cellsAkt signaling pathwayExtracellular matrixSignaling pathwayDipeptidyl peptidase IVMesangial cellsExpression of ECM-related proteinsPhosphorylation of AktECM-related proteinsAbnormal extracellular matrixECM depositionExcessive deposition of extracellular matrixPhosphorylation of Smad2DPP8/9 inhibitionDeposition of extracellular matrixGlomerular mesangial cellsDPP9Collagen IVDPP8AktMultiple diseasesDPP8/9SiRNAPathogenesis of glomerular diseaseCells