2024
Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls
Díaz D, Tseng W, Michalska K. Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls. BMC Psychiatry 2024, 24: 1. PMID: 38167015, PMCID: PMC10759434, DOI: 10.1186/s12888-023-05403-6.Peer-Reviewed Original ResearchConceptsState anxietyTrait anxietyHappy facesEmotion processingLatina girlsImplicit emotion processingNon-anxious youthHigh trait anxietyFearful facial affectFearful facesEmotional valenceFacial affectNeural correlatesIndividual differencesBrain activationBrain responsesNeural activationReduced engagementCommunity sampleAnxietyInteractive effectsHigh levelsGirlsMethodsThe present studySystematic differences
2022
Characterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®
Lee KS, Xiao J, Luo J, Leibenluft E, Liew Z, Tseng WL. Characterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®. Frontiers In Psychiatry 2022, 13: 803891. PMID: 35308882, PMCID: PMC8931695, DOI: 10.3389/fpsyt.2022.803891.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderResponse inhibitionError processingNeural correlatesIrritability symptomsHyperactivity disorderHigher attention-deficit/hyperactivity disorderAdolescent Brain Cognitive Development (ABCD) studySymptoms of inattentionDifferential neural mechanismsCognitive Development StudyStop-signal taskLow frustration toleranceLatent class analysisFronto-parietal regionsLatent variable modelingPediatric irritabilityNeural differencesIndividual differencesSignal taskExecutive dysfunctionFrustration toleranceNeural mechanismsABCD studyHigh irritability
2021
Neural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability
Tseng WL, Abend R, Gold AL, Brotman MA. Neural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability. Journal Of Affective Disorders 2021, 295: 920-929. PMID: 34706463, PMCID: PMC8554134, DOI: 10.1016/j.jad.2021.08.117.Peer-Reviewed Original ResearchConceptsHigh negative affectivityNegative affectivityThreat appraisalPediatric anxietyAnxiety disordersThreat-safety discriminationWhole-brain activationLinear mixed effects analysisNegative affectivity factorExtinction recallThreat conditioningThreat contingenciesElevated irritabilityNeural correlatesTransdiagnostic sampleGreater prefrontalOccipital activationUnique varianceExplicit recallThreat responsesFMRI paradigmNeural mechanismsTask conditionsAmygdala connectivityMixed effects analysis
2018
Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths
Tseng WL, Deveney CM, Stoddard J, Kircanski K, Frackman AE, Yi JY, Hsu D, Moroney E, Machlin L, Donahue L, Roule A, Perhamus G, Reynolds RC, Roberson-Nay R, Hettema JM, Towbin KE, Stringaris A, Pine DS, Brotman MA, Leibenluft E. Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths. American Journal Of Psychiatry 2018, 176: 67-76. PMID: 30336704, PMCID: PMC6408218, DOI: 10.1176/appi.ajp.2018.18040491.Peer-Reviewed Original ResearchConceptsLevels of irritabilityWhole-brain activation analysesRegulation of emotionAffective Reactivity IndexInferior frontal gyrusFunctional MRI paradigmDorsolateral prefrontal cortexAnterior cingulate cortexAttention orientingNeural correlatesTransdiagnostic sampleBrain mechanismsFMRI paradigmChildhood irritabilityFrontal gyrusNeural activationChild reportsMotor executionPrefrontal cortexHigh irritabilityCingulate cortexNeural systemsYounger youthNeural activityOlder youthA Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth
Kircanski K, White LK, Tseng WL, Wiggins JL, Frank HR, Sequeira S, Zhang S, Abend R, Towbin KE, Stringaris A, Pine DS, Leibenluft E, Brotman MA. A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 2018, 75: 631-639. PMID: 29625429, PMCID: PMC6137523, DOI: 10.1001/jamapsychiatry.2018.0468.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesCaudate NucleusCerebral CortexChildCross-Sectional StudiesFemaleFunctional NeuroimagingHumansIrritable MoodLatent Class AnalysisMagnetic Resonance ImagingMaleMood DisordersNeural PathwaysParietal LobePrefrontal CortexConceptsParent-reported irritabilityNeural mechanismsAnxiety symptomsLatent variable approachPediatric irritabilityNeural correlatesAmygdala connectivityShared varianceCross-sectional functional magnetic resonance imaging studyNeural activityFunctional magnetic resonance imaging studyDot-probe taskAffective Reactivity IndexVentrolateral prefrontal cortexCommon neural mechanismsAmygdala functional connectivityFunctional magnetic resonanceLevels of irritabilityWhole-brain analysisInferior parietal lobuleData-driven phenotypingMultiple diagnostic categoriesCo-occurring symptomsMagnetic resonance imaging studyNeutral faces
2015
Neural correlates of masked and unmasked face emotion processing in youth with severe mood dysregulation
Tseng WL, Thomas LA, Harkins E, Pine DS, Leibenluft E, Brotman MA. Neural correlates of masked and unmasked face emotion processing in youth with severe mood dysregulation. Social Cognitive And Affective Neuroscience 2015, 11: 78-88. PMID: 26137973, PMCID: PMC4692312, DOI: 10.1093/scan/nsv087.Peer-Reviewed Original ResearchConceptsSevere mood dysregulationFace emotion processingFunctional magnetic resonance imagingEmotion processingParahippocampal gyrusNeural correlatesMood dysregulationVentromedial prefrontal cortex activationAffective priming paradigmPrefrontal cortex activationSuperior temporal gyrusAngry facesFace processingHappy facesSMD patientsPositive emotionsPriming paradigmVmPFC dysfunctionNegative emotionsTemporal gyrusCortex activationEmotionsFMRI dataDecreased activationIndependent samples