2023
Can peripheral psychophysiological markers predict response to exposure-based cognitive behavioral therapy in youth with severely impairing irritability? A study protocol
Grasser L, Erjo T, Goodwin M, Naim R, German R, White J, Cullins L, Tseng W, Stoddard J, Brotman M. Can peripheral psychophysiological markers predict response to exposure-based cognitive behavioral therapy in youth with severely impairing irritability? A study protocol. BMC Psychiatry 2023, 23: 926. PMID: 38082431, PMCID: PMC10712194, DOI: 10.1186/s12888-023-05421-4.Peer-Reviewed Original ResearchConceptsExposure-based cognitive-behavioral therapyCognitive behavioral therapyPhysiological arousalBehavioral therapyAffective Reactivity IndexMultiple baseline trialClinical Global Impression ScaleAnger-inducing stimuliPeripheral physiological indicatorsIndividual differencesPsychophysiological markersPerson changesExposure sessionsMultilevel modelingPsychophysiological indicatorsHR/HRVInitial evidenceMental healthReasons youthReactivity indexYouthAppropriate Institutional Review BoardTreatment mechanismsGlobal Impression ScaleCourse of treatment
2021
Perinatal and birth correlates of childhood irritability in Taiwan's national epidemiological study
Lee KS, Xiao J, Liew Z, Gau SS, Tseng WL. Perinatal and birth correlates of childhood irritability in Taiwan's national epidemiological study. Journal Of Affective Disorders 2021, 299: 273-280. PMID: 34906640, PMCID: PMC8767526, DOI: 10.1016/j.jad.2021.12.016.Peer-Reviewed Original ResearchConceptsNational epidemiological studyBirth characteristicsEpidemiological studiesChildhood irritabilityEarly life exposureAdverse mental healthBirth correlatesPerinatal perspectiveVaginal bleedingMaternal smokingAffective Reactivity IndexPerinatal risksBirth factorsLife exposureProspective assessmentIrritabilityTemper outburstsRecall biasLife outcomesPerinatalMental healthEarly etiologyChild irritabilityRetrospective assessmentEnvironmental exposuresFunctional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry
2018
Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths
Tseng WL, Deveney CM, Stoddard J, Kircanski K, Frackman AE, Yi JY, Hsu D, Moroney E, Machlin L, Donahue L, Roule A, Perhamus G, Reynolds RC, Roberson-Nay R, Hettema JM, Towbin KE, Stringaris A, Pine DS, Brotman MA, Leibenluft E. Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths. American Journal Of Psychiatry 2018, 176: 67-76. PMID: 30336704, PMCID: PMC6408218, DOI: 10.1176/appi.ajp.2018.18040491.Peer-Reviewed Original ResearchConceptsLevels of irritabilityWhole-brain activation analysesRegulation of emotionAffective Reactivity IndexInferior frontal gyrusFunctional MRI paradigmDorsolateral prefrontal cortexAnterior cingulate cortexAttention orientingNeural correlatesTransdiagnostic sampleBrain mechanismsFMRI paradigmChildhood irritabilityFrontal gyrusNeural activationChild reportsMotor executionPrefrontal cortexHigh irritabilityCingulate cortexNeural systemsYounger youthNeural activityOlder youthA Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth
Kircanski K, White LK, Tseng WL, Wiggins JL, Frank HR, Sequeira S, Zhang S, Abend R, Towbin KE, Stringaris A, Pine DS, Leibenluft E, Brotman MA. A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 2018, 75: 631-639. PMID: 29625429, PMCID: PMC6137523, DOI: 10.1001/jamapsychiatry.2018.0468.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesCaudate NucleusCerebral CortexChildCross-Sectional StudiesFemaleFunctional NeuroimagingHumansIrritable MoodLatent Class AnalysisMagnetic Resonance ImagingMaleMood DisordersNeural PathwaysParietal LobePrefrontal CortexConceptsParent-reported irritabilityNeural mechanismsAnxiety symptomsLatent variable approachPediatric irritabilityNeural correlatesAmygdala connectivityShared varianceCross-sectional functional magnetic resonance imaging studyNeural activityFunctional magnetic resonance imaging studyDot-probe taskAffective Reactivity IndexVentrolateral prefrontal cortexCommon neural mechanismsAmygdala functional connectivityFunctional magnetic resonanceLevels of irritabilityWhole-brain analysisInferior parietal lobuleData-driven phenotypingMultiple diagnostic categoriesCo-occurring symptomsMagnetic resonance imaging studyNeutral faces
2017
Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology
Stoddard J, Tseng WL, Kim P, Chen G, Yi J, Donahue L, Brotman MA, Towbin KE, Pine DS, Leibenluft E. Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology. JAMA Psychiatry 2017, 74: 95-103. PMID: 27902832, PMCID: PMC6309540, DOI: 10.1001/jamapsychiatry.2016.3282.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxiety DisordersArousalAttention Deficit Disorder with HyperactivityBrainChildCross-Sectional StudiesDominance, CerebralEmotionsFacial RecognitionFemaleHumansIrritable MoodMagnetic Resonance ImagingMaleMental DisordersMood DisordersNerve NetPrefrontal CortexPsychopathologyConceptsFunctional magnetic resonance imagingPrefrontal cortex connectivityFace emotionsNeural responsesCortex connectivityMedial prefrontal cortex connectivityAttention-deficit/hyperactivity disorderChild Anxiety Related DisordersThreat-related facesDisruptive Mood DysregulationPathophysiology of irritabilityFace emotion processingAmygdala-medial prefrontal cortex connectivityCross-sectional functional magnetic resonanceAffective Reactivity IndexBrain-behavior relationshipsVentral visual areasAssociations of irritabilityUnique effectsAmygdala functional connectivityAnxiety Related DisordersFunctional magnetic resonanceYouth ages 8Angry facesFearful faces