2024
Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023
Burak M, Stanley T, Lawson E, Campbell S, Lynch L, Hasty A, Domingos A, Dixit V, Hotamışlıgil G, Sheedy F, Dixon A, Brinkley T, Hill J, Donath M, Grinspoon S. Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023. American Journal Of Clinical Nutrition 2024, 120: 257-268. PMID: 38705359, PMCID: PMC11347817, DOI: 10.1016/j.ajcnut.2024.04.029.Peer-Reviewed Original ResearchLow-grade systemic inflammationChronic low-grade inflammationLocal immune environmentAdipose tissueLow-grade inflammationEffect of obesityObesity Research CenterPro-inflammatory pathwaysOutcome of metabolic diseasesImmune environmentSystemic inflammationHealth and DiseaseTreatment therapiesInflammationMultifaceted effectsDisease severityMetabolic diseasesImmunometabolic diseasesImmunityAdiposeDiseaseReduced disease severityObesityTissueDisrupting cellular homeostasis
2023
Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation
Goldberg E, Letian A, Dlugos T, Leveau C, Dixit V. Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation. Journal Of Biological Chemistry 2023, 299: 103005. PMID: 36775129, PMCID: PMC10025153, DOI: 10.1016/j.jbc.2023.103005.Peer-Reviewed Original ResearchConceptsAge-related inflammationKetone bodiesOrganismal metabolismMyeloid cellsChronic low-grade inflammationKetogenic diet feedingLow-grade inflammationHigh-fat dietAbundant ketone bodyGlucose toleranceNLRP3 inflammasomeDiet feedingGlucose homeostasisMouse modelBody weightInflammationMetabolic checkpointOnly organConditional ablationTerminal enzymeΒ-hydroxybutyrateFunctional targetingMethylglutaryl-CoA lyaseKetogenesisModest effect