2024
The impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction
Hazan H, Ferrara M, Riley S, Li F, Zhou B, Kline E, Gibbs-Dean T, Karmani S, Tayfur S, Tek C, Keshavan M, Srihari V. The impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction. Schizophrenia Research 2024, 264: 457-461. PMID: 38266513, PMCID: PMC10923115, DOI: 10.1016/j.schres.2024.01.022.Peer-Reviewed Original ResearchConceptsCoordinated specialty careDuration of untreated psychosisImpact of early detectionEarly detectionEarly detection campaignsSpecialty careAdjustment scoresCampaign yearDetection campaignsMediation analysisEffects of EDRegression modelsCareUntreated psychosisPositive symptomsGAFPatientsSalutary effects
2021
Taking the next step: Improving care transitions from a first‐episode psychosis service
Gallagher K, Ferrara M, Pollard J, Sykes L, Li F, Imetovski S, Cahill J, Mathis W, Srihari VH. Taking the next step: Improving care transitions from a first‐episode psychosis service. Early Intervention In Psychiatry 2021, 16: 91-96. PMID: 35029048, DOI: 10.1111/eip.13127.Peer-Reviewed Original ResearchConceptsFirst-episode servicesQuality improvement approachQI approachExact testFirst-episode psychosis servicesUnknown treatment statusRecent-onset psychosisFisher's exact testDischarge planning processStudy-Act cyclesDischarge planningCare transitionsCare 3Onset psychosisDisposition planningPsychosis servicesTreatment statusFunctional gainsPatient engagementQI phasePlan-DoPatientsDisposition outcomesTransfer statusMonths
2020
Systematic review of racial disparities in clozapine prescribing
Williams JC, Harowitz J, Glover J, Tek C, Srihari V. Systematic review of racial disparities in clozapine prescribing. Schizophrenia Research 2020, 224: 11-18. PMID: 33183948, DOI: 10.1016/j.schres.2020.07.023.Peer-Reviewed Original ResearchConceptsMinority patientsSystematic reviewRelevant covariatesRacial disparitiesUnderutilization of clozapineClinician-related factorsPatient-related factorsRacial minority patientsClozapine prescribingClozapine underutilizationHospital stayPrescription ratesAntipsychotic medicationIndependent reviewersEligibility criteriaElectronic databasesDisease severityRelevant studiesPrescribingPatientsInstitution-related factorsWhite counterpartsDirect examinationRacial groupsPossible causesDrug‐naïve first‐episode schizophrenia spectrum disorders: Pharmacological treatment practices in inpatient units in Hunan Province, China
Zhu M, Ferrara M, Tan W, Shang X, Syed S, Zhang L, Qin Q, Hu X, Rohrbaugh R, Srihari VH, Liu Z. Drug‐naïve first‐episode schizophrenia spectrum disorders: Pharmacological treatment practices in inpatient units in Hunan Province, China. Early Intervention In Psychiatry 2020, 15: 1010-1018. PMID: 32924286, PMCID: PMC8359180, DOI: 10.1111/eip.13046.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersSingle antipsychoticCurrent guidelinesFirst-episode schizophrenia spectrum disordersAntipsychotic prescription patternsHigh-dose antipsychoticsBest practice treatmentYears of ageElectronic medical recordsClinical characteristicsPrescription patternsClinical factorsInjectable antipsychoticsUntreated illnessMedical recordsFirst episodeAntipsychoticsInpatient unitPolypharmacyPsychiatric hospitalChina GuidelinesInpatientsLogistic regressionPatientsTreatment practices
2018
Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study
Kang C, Zhou H, Yang J, Yang R, Sun N, Wang S, Yang C, Han D, Srihari VH. Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study. Psychiatry Research 2018, 271: 144-149. PMID: 30472510, DOI: 10.1016/j.psychres.2018.11.013.Peer-Reviewed Original ResearchConceptsEarly-onset schizophreniaICD-10 diagnosisDiagnostic stabilityMini International Neuropsychiatric InterviewFirst Affiliated HospitalInternational Neuropsychiatric InterviewKunming Medical UniversityHigh diagnostic stabilityDepartment of PsychiatryPoor outcomeAffiliated HospitalNeuropsychiatric InterviewInternational ClassificationBetter outcomesModerate outcomeMedical UniversityGlobal functioningICD-10Psychosocial outcomesPatientsSchizophreniaDiagnosis stabilityDiagnosisOutcomesHospitalGlucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis
Kucukgoncu S, Kosir U, Zhou E, Sullivan E, Srihari VH, Tek C. Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis. Early Intervention In Psychiatry 2018, 13: 1021-1031. PMID: 30277314, PMCID: PMC6445792, DOI: 10.1111/eip.12749.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisSevere mental illnessGlucose metabolism outcomesTreatment-naïveEpisode psychosisMood disordersMental illnessSystematic reviewGlucose tolerance test resultsInsulin resistance levelsImpaired glucose metabolismFirst-episode patientsTolerance test resultsHigh-risk groupMood disorder groupGlucose intoleranceEpisode patientsDiabetes developmentMetabolism dysregulationEligible studiesHealthy controlsHigh insulinFEP groupGlucose metabolismPatientsTransforming the Treatment of Schizophrenia in the United States: The RAISE Initiative
Dixon LB, Goldman HH, Srihari VH, Kane JM. Transforming the Treatment of Schizophrenia in the United States: The RAISE Initiative. Annual Review Of Clinical Psychology 2018, 14: 1-22. PMID: 29328779, PMCID: PMC8990328, DOI: 10.1146/annurev-clinpsy-050817-084934.Peer-Reviewed Original ResearchConceptsCoordinated Specialty CareInitial Schizophrenia Episode projectExtensive functional impairmentPatient Outcomes Research TeamTreatment of schizophreniaSchizophrenia spectrum disordersEvidence-based practiceUntreated psychosisSpecialty careChronic schizophreniaCSC programsEpisode ProjectFunctional impairmentLifetime prevalenceRAISE studyRecovery of individualsTreatment settingsEarly interventionNeurodevelopmental illnessSchizophreniaTreatmentUnited StatesInternational studiesSpectrum disorderPatients
2017
First-Episode Psychosis and the Criminal Justice System: Using a Sequential Intercept Framework to Highlight Risks and Opportunities
Wasser T, Pollard J, Fisk D, Srihari V. First-Episode Psychosis and the Criminal Justice System: Using a Sequential Intercept Framework to Highlight Risks and Opportunities. Psychiatric Services 2017, 68: 994-996. PMID: 28859587, DOI: 10.1176/appi.ps.201700313.Peer-Reviewed Original ResearchConceptsCriminal justice systemJustice systemSubsequent criminal justice involvementSequential Intercept ModelCriminal justice involvementCriminal justiceLegal outcomesDiversionary programsCaseload burdenHighlight risksJustice involvementClinical sphereIntercept modelFirst-episode psychosisMental health servicesJusticeEpisode psychosisHealth servicesRisk of aggressionSpherePsychosisRiskOpportunitiesFrameworkPatients
2016
Antipsychotic-Induced Weight Gain in First-Episode Psychosis Patients: A Meta-Analysis of Differential Effects of Antipsychotic Medications
Tek C, Kucukgoncu S, Guloksuz S, Woods SW, Srihari VH, Annamalai A. Antipsychotic-Induced Weight Gain in First-Episode Psychosis Patients: A Meta-Analysis of Differential Effects of Antipsychotic Medications. FOCUS The Journal Of Lifelong Learning In Psychiatry 2016, 14: 370-377. PMID: 31997958, PMCID: PMC6988756, DOI: 10.1176/appi.focus.140308.Peer-Reviewed Original Research
2015
Antipsychotic‐induced weight gain in first‐episode psychosis patients: a meta‐analysis of differential effects of antipsychotic medications
Tek C, Kucukgoncu S, Guloksuz S, Woods SW, Srihari VH, Annamalai A. Antipsychotic‐induced weight gain in first‐episode psychosis patients: a meta‐analysis of differential effects of antipsychotic medications. Early Intervention In Psychiatry 2015, 10: 193-202. PMID: 25962699, PMCID: PMC5589463, DOI: 10.1111/eip.12251.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisAP medicationFEP patientsBody weight gainBMI increaseWeight gainAP useBody mass index (BMI) changeSignificant body weight gainWeight gain riskMore weight gainComprehensive literature searchMean weight gainMeta-regression analysisBaseline weightBMI changeModifiable factorsBMI differencesMedicationsBMI outcomesPlaceboHigher weight gainBMILiterature searchPatientsToo Late and Too Little: Narratives of Treatment Disconnect in Early Psychosis
van Schalkwyk GI, Davidson L, Srihari V. Too Late and Too Little: Narratives of Treatment Disconnect in Early Psychosis. Psychiatric Quarterly 2015, 86: 521-532. PMID: 25663602, PMCID: PMC5576358, DOI: 10.1007/s11126-015-9348-4.Peer-Reviewed Original ResearchConceptsFirst episode psychosis programLong-term outcomesSpecialized treatment servicesOnset of psychosisInitial contactSpecialized servicesYounger patientsSignificant morbidityPsychosis programPatient preferencesEarly treatmentEffective treatmentEarly psychosisPsychiatric careTreatment experienceTreatment prioritiesPsychotic disordersTreatment servicesPatientsInductive thematic analysisFurther treatmentTreatmentDisproportionate improvementBehavioral changesCritical periodFirst-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial
Srihari VH, Tek C, Kucukgoncu S, Phutane VH, Breitborde NJ, Pollard J, Ozkan B, Saksa J, Walsh BC, Woods SW. First-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial. Psychiatric Services 2015, 66: 705-712. PMID: 25639994, PMCID: PMC4490067, DOI: 10.1176/appi.ps.201400236.Peer-Reviewed Original ResearchConceptsUsual treatmentSTEP participantsCommunity mental health centerFirst-episode servicesFirst-episode psychosisMental health centersSerious mental illnessInpatient psychiatric unitAntipsychotic exposureAdditional patientsIllness onsetHospital utilizationHealth centersInpatient utilizationPsychiatric hospitalizationMAIN OUTCOMEPsychotic illnessPsychiatric unitPsychotic disordersHospitalizationEarly interventionMental illnessSpecialized treatmentPatientsTranslational researchEquivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients
Hay RA, Roach BJ, Srihari VH, Woods SW, Ford JM, Mathalon DH. Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients. Biological Psychology 2015, 105: 130-137. PMID: 25603283, PMCID: PMC4336819, DOI: 10.1016/j.biopsycho.2015.01.004.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum patientsHealthy controlsEarly schizophrenia patientsMMN amplitude reductionDuration of illnessCourse of schizophreniaMismatch negativityDeviant typesMismatch negativity deficitsClinical symptomsDifferent deviant typesNeurophysiological abnormalitiesAuditory deviantsSchizophrenia patientsPatientsAuditory deviance processingIllnessNeurophysiological mechanismsAmplitude reductionSignificant interactionMMN responsesDeviance processingSymptomsAbnormalitiesSchizophrenia
2014
Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study
Srihari VH, Tek C, Pollard J, Zimmet S, Keat J, Cahill JD, Kucukgoncu S, Walsh BC, Li F, Gueorguieva R, Levine N, Mesholam-Gately RI, Friedman-Yakoobian M, Seidman LJ, Keshavan MS, McGlashan TH, Woods SW. Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study. BMC Psychiatry 2014, 14: 335. PMID: 25471062, PMCID: PMC4262386, DOI: 10.1186/s12888-014-0335-3.Peer-Reviewed Original ResearchConceptsEarly detectionEarly outcomesGeographic catchmentTIPS studyYounger patientsAppropriate patientsUntreated psychosisPsychosis onsetEffective treatmentCare providersPsychotic symptomsPublic education campaignsPsychotic disordersHelp-seeking behaviorSecondary aimComprehensive interventionPatientsIntervention servicesDUPEducation campaignsOutcomesSocial marketing approachPrimary aimTreatmentFESThe impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: A double-blind, randomized, placebo-controlled trial
Tek C, Palmese LB, Krystal AD, Srihari VH, DeGeorge PC, Reutenauer EL, Guloksuz S. The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: A double-blind, randomized, placebo-controlled trial. Schizophrenia Research 2014, 160: 180-185. PMID: 25454802, PMCID: PMC5589464, DOI: 10.1016/j.schres.2014.10.002.Peer-Reviewed Original ResearchMeSH KeywordsAzabicyclo CompoundsCognitionDouble-Blind MethodEszopicloneFemaleHumansHypnotics and SedativesMaleMedical RecordsMiddle AgedPatient DropoutsPiperazinesPsychotic DisordersQuality of LifeSchizophreniaSchizophrenic PsychologySingle-Blind MethodSleepSleep Initiation and Maintenance DisordersTreatment OutcomeConceptsInsomnia Severity IndexSingle-blind placebo phasePlacebo phaseOutcome measuresPsychiatric symptomsPlacebo-controlled trialDouble-blind placeboSecondary outcome measuresPrimary outcome measureEffects of eszopicloneBetween-group differencesTreatment of insomniaQuality of lifeDiscontinuation ratesMATRICS Consensus Cognitive BatteryStable outpatientsConsensus Cognitive BatterySchizoaffective disorderCognitive impairmentSleep diaryPatientsInsomniaScore changeEszopiclonePlacebo
2013
Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity
Perez VB, Woods SW, Roach BJ, Ford JM, McGlashan TH, Srihari VH, Mathalon DH. Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity. Biological Psychiatry 2013, 75: 459-469. PMID: 24050720, PMCID: PMC4028131, DOI: 10.1016/j.biopsych.2013.07.038.Peer-Reviewed Original ResearchConceptsCHR patientsHealthy control subjectsPsychosis onsetControl subjectsClinical high-risk patientsEarly illness schizophrenia patientsPsychosis riskClinical high-risk individualsHigh-risk patientsThird of patientsHigh-risk individualsCurrent clinical criteriaAuditory processing deficitsMismatch negativityNonclinical measuresAuditory devianceCox regressionClinical criteriaUnnecessary treatmentHigh riskCHR convertersPatientsPsychotic disordersSchizophrenia patientsPreventive interventionsChapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia
Perez VB, Roach BJ, Woods SW, Srihari VH, McGlashan TH, Ford JM, Mathalon DH. Chapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia. Supplements To Clinical Neurophysiology 2013, 62: 147-162. PMID: 24053038, PMCID: PMC4120874, DOI: 10.1016/b978-0-7020-5307-8.00010-7.Peer-Reviewed Original ResearchConceptsClinical high riskPhase-locking factorGamma-band responseAuditory gamma-band responsesCHR patientsHigh riskSchizophrenia patientsChronic schizophrenia patientsNMDA glutamate receptorsYounger schizophrenia patientsTransient gamma-band responseTrend-level reductionsNeurotransmission abnormalitiesGamma-band oscillationsYounger patientsIllness onsetProdromal symptomsPhase synchronyProdromal periodHealthy controlsPsychosis onsetPatientsPsychotic disordersCHR groupElectroencephalographic studies
2012
Error Monitoring Dysfunction Across the Illness Course of Schizophrenia
Perez VB, Ford JM, Roach BJ, Woods SW, McGlashan TH, Srihari VH, Loewy RL, Vinogradov S, Mathalon DH. Error Monitoring Dysfunction Across the Illness Course of Schizophrenia. Journal Of Psychopathology And Clinical Science 2012, 121: 372-387. PMID: 22060947, PMCID: PMC3358508, DOI: 10.1037/a0025487.Peer-Reviewed Original ResearchConceptsEarly illness schizophrenia patientsClinical high-risk patientsSchizophrenia patientsIllness courseAge-matched healthy controlsHigh-risk patientsAge-matched HCChronic schizophrenia patientsOnset of psychosisCorrect response negativityPE abnormalitiesRisk patientsCHR patientsClinical prodromeEvent-related potentialsIllness durationHealthy controlsIllness progressionPsychosis onsetPatientsAbnormalitiesIllnessResponse monitoringError-related negativityOnset
2011
Who Is Paying the Price? Loss of Health Insurance Coverage Early in Psychosis
Dodds TJ, Phutane VH, Stevens BJ, Woods SW, Sernyak MJ, Srihari VH. Who Is Paying the Price? Loss of Health Insurance Coverage Early in Psychosis. Psychiatric Services 2011, 62: 878-881. PMID: 21807825, PMCID: PMC4469900, DOI: 10.1176/ps.62.8.pss6208_0878.Peer-Reviewed Original ResearchConceptsHealth insurance coverageInsurance coverageConnecticut Mental Health CenterClinical chart reviewEarly psychosis patientsLong-term outcomesContinuity of careMental health centersPeriod of illnessChart reviewInsurance statusHealth centersEarly psychosisSpecialty servicesClinician reportsPrivate insurancePublic insuranceSpecialized treatmentPsychosisHealth insuranceMonthsOne-thirdParticipantsInsurancePatientsHoofbeats and zebras: neurodegenerative disorder presenting as a “first episode” of psychosis
Ozkan B, Phutane V, Jonas E, Tek C, Srihari V. Hoofbeats and zebras: neurodegenerative disorder presenting as a “first episode” of psychosis. General Hospital Psychiatry 2011, 33: 412.e1-412.e3. PMID: 21762843, PMCID: PMC3139144, DOI: 10.1016/j.genhosppsych.2011.03.011.Peer-Reviewed Original ResearchConceptsNeurodegenerative disordersDiverse neuropsychiatric symptomsBrain magnetic resonanceProgressive cortical atrophyCortical atrophyPsychosis clinicNeuropsychiatric symptomsFirst episodeFrontal lobeAuditory hallucinationsBehavioral declineDisordersParanoid ideationMagnetic resonancePatientsAtrophyClinicSymptomsPsychosisHallucinations