2024
Antipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration
Szmulewicz A, Martínez-Alés G, Logan R, Ferrara M, Kelly C, Fredrikson D, Gago J, Conderino S, Díaz-Caneja C, Galvañ J, Thorpe L, Srihari V, Yatham L, Sarpal D, Shinn A, Arango C, Öngür D, Hernán M, Collaboration O. Antipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration. American Journal Of Epidemiology 2024, 193: 1081-1087. PMID: 38576166, DOI: 10.1093/aje/kwae029.Peer-Reviewed Original ResearchFirst-episode psychosisFirst-generation agentsAntipsychotic therapyAntipsychotic drugsPsychosis onsetPsychotic disordersEpisode psychosisAripiprazolePaliperidoneRisk of hospitalizationPsychosisTarget trialsRisperidoneOlanzapineFirst-line therapyTreatment discontinuationEUFESTObservational cohortAntipsychoticsQuetiapineRandomized trialsPrimary outcomeAbsolute riskRisk differenceClinical questions
2020
Drug‐naïve first‐episode schizophrenia spectrum disorders: Pharmacological treatment practices in inpatient units in Hunan Province, China
Zhu M, Ferrara M, Tan W, Shang X, Syed S, Zhang L, Qin Q, Hu X, Rohrbaugh R, Srihari VH, Liu Z. Drug‐naïve first‐episode schizophrenia spectrum disorders: Pharmacological treatment practices in inpatient units in Hunan Province, China. Early Intervention In Psychiatry 2020, 15: 1010-1018. PMID: 32924286, PMCID: PMC8359180, DOI: 10.1111/eip.13046.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersSingle antipsychoticCurrent guidelinesFirst-episode schizophrenia spectrum disordersAntipsychotic prescription patternsHigh-dose antipsychoticsBest practice treatmentYears of ageElectronic medical recordsClinical characteristicsPrescription patternsClinical factorsInjectable antipsychoticsUntreated illnessMedical recordsFirst episodeAntipsychoticsInpatient unitPolypharmacyPsychiatric hospitalChina GuidelinesInpatientsLogistic regressionPatientsTreatment practices