2024
Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock
Atreya M, Bennett T, Geva A, Faustino E, Rogerson C, Lutfi R, Cvijanovich N, Bigham M, Nowak J, Schwarz A, Baines T, Haileselassie B, Thomas N, Luo Y, Sanchez-Pinto L, Investigators F. Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock. Pediatric Critical Care Medicine 2024, 25: 512-517. PMID: 38465952, PMCID: PMC11153020, DOI: 10.1097/pcc.0000000000003499.Peer-Reviewed Original ResearchElectronic health recordsMultiple organ dysfunction syndromePediatric septic shock patientsSeptic shock patientsRisk strataElectronic health record dataSepsis phenotypesShock patientsPersistent multiple organ dysfunction syndromeAssociated with poor clinical outcomesDegree of systemic inflammationIncreased adjusted oddsHigh riskOrgan dysfunction syndromePoor clinical outcomesHealth recordsReceiver operating characteristic curveHigh-risk stratumArea under the receiver operating characteristic curveCritically ill patientsPredictive of deathSeverity of illnessAdjusted oddsIdentification of childrenOperating characteristics curveConsiderations for instituting pediatric pulmonary embolism response teams: A tool kit
Rajpurkar M, Rosovsky R, Williams S, Chan A, van Ommen C, Faustino E, White M, Parikh M, Sirachainan N, Biss T, Goldenberg N. Considerations for instituting pediatric pulmonary embolism response teams: A tool kit. Thrombosis Research 2024, 236: 97-107. PMID: 38417301, DOI: 10.1016/j.thromres.2024.02.019.Peer-Reviewed Original ResearchPulmonary Embolism Response TeamPediatric pulmonary embolismPediatric PETime to diagnosisIndividual physician's experiencePulmonary embolismDefinitive managementPE patientsResponse teamCritical care pathwayEpidemiological featuresCare pathwaysPhysician experiencePractice guidelinesPE outcomesDiagnosisCritical pathwaysPlatelet Mitochondrial Fusion and Function in Vascular Integrity
Tyagi T, Yarovinsky T, Faustino E, Hwa J. Platelet Mitochondrial Fusion and Function in Vascular Integrity. Circulation Research 2024, 134: 162-164. PMID: 38236952, PMCID: PMC10798220, DOI: 10.1161/circresaha.123.323867.Peer-Reviewed Original Research
2023
778: USE OF PERIPHERALLY INSERTED CENTRAL CATHETERS IN INFANTS: PICC STUDY
Chegondi M, Ness-Cochinwala M, Pinto M, Schreiber H, Polikoff L, Kerris E, Kothari H, Bloxham J, Berman-Sieger A, Mancuso B, Harder T, Korn S, Gillette C, Taillie E, Cholette J, Johnson R, Kaipa S, Faustino E. 778: USE OF PERIPHERALLY INSERTED CENTRAL CATHETERS IN INFANTS: PICC STUDY. Critical Care Medicine 2023, 52: s361-s361. DOI: 10.1097/01.ccm.0001001280.97724.e1.Peer-Reviewed Original Research813: BLOOD PRODUCT UTILIZATION IN INFANTS WITH PERIPHERALLY INSERTED CENTRAL CATHETERS
Ness-Cochinwala M, Chegondi M, Mancuso B, Berman-Sieger A, Pinto M, Schreiber H, Polikoff L, Kaipa S, Kerris E, Kothari H, Bloxham J, Harder T, Korn S, Gillette C, Taillie E, Cholette J, Johnson R, Faustino E. 813: BLOOD PRODUCT UTILIZATION IN INFANTS WITH PERIPHERALLY INSERTED CENTRAL CATHETERS. Critical Care Medicine 2023, 52: s379-s379. DOI: 10.1097/01.ccm.0001001420.46206.99.Peer-Reviewed Original ResearchMulticenter Study of a Risk Prediction Model for Critically Ill Children at High-Risk for Hospital-Acquired Venous Thromboembolism: Findings from the Children's Hospital-Acquired Thrombosis (CHAT) Consortium
Jaffray J, Mosha M, Branchford B, Amankwah E, Faustino E, Krava E, Stillings A, Young G, Goldenberg N. Multicenter Study of a Risk Prediction Model for Critically Ill Children at High-Risk for Hospital-Acquired Venous Thromboembolism: Findings from the Children's Hospital-Acquired Thrombosis (CHAT) Consortium. Blood 2023, 142: 809. DOI: 10.1182/blood-2023-187395.Peer-Reviewed Original ResearchHospital-acquired venous thromboembolismPediatric intensive care unitCongenital heart diseaseIll childrenMultivariable logistic regression modelAdmission/transferAutoimmune/inflammatory disordersCentral venous cathetersLength of hospitalizationCentral venous catheterizationDays post dischargeIntensive care unitUnivariate logistic regressionSubset of childrenP-valueLogistic regression modelsRisk assessment modelPICU admissionThromboprophylaxis measuresVenous thromboembolismChart reviewProspective cohortVenous cathetersCardiac surgeryMedian ageInflammation Sub-Group Analysis in Pediatric HA-VTE Cases: A Report from the Children's Hospital Acquired Thrombosis Registry (CHAT) Registry
Harp T, Proctor K, Mosha M, Cox A, Jaffray J, Stillings A, Krava E, Amankwah E, Faustino E, Zakai N, Young G, Goldenberg N, Branchford B. Inflammation Sub-Group Analysis in Pediatric HA-VTE Cases: A Report from the Children's Hospital Acquired Thrombosis Registry (CHAT) Registry. Blood 2023, 142: 4015. DOI: 10.1182/blood-2023-190491.Peer-Reviewed Original ResearchPast medical historyInflammatory disease diagnosisHA-VTEDischarge diagnosisSystemic inflammationChronic inflammationAcute inflammationInflammatory diseasesOdds ratioCentral venous catheter placementAdmission/transferDays of dischargeLong-term morbidityVenous catheter placementOrgan system involvementPediatric patient populationType of inflammationClinical research effortsSub-group analysisUnderlying risk factorsInstitutional review boardElectronic health recordsChronic varietyHospital stayVenous thromboembolismHospital-Acquired Venous Thromboembolism and Invasive Mechanical Ventilation: A Report From the Children’s Hospital Acquired Thrombosis Consortium
Sochet A, Jaffray J, Branchford B, Havlicek E, Mosha M, Amankwah E, Ignjatovic V, Faustino E, Goldenberg N. Hospital-Acquired Venous Thromboembolism and Invasive Mechanical Ventilation: A Report From the Children’s Hospital Acquired Thrombosis Consortium. Pediatric Critical Care Medicine 2023, 25: e82-e90. PMID: 37882641, PMCID: PMC10843146, DOI: 10.1097/pcc.0000000000003383.Peer-Reviewed Original ResearchHospital-acquired venous thromboembolismInvasive mechanical ventilationIMV durationVenous thromboembolismMechanical ventilationIll childrenDeep venous thrombosesPatient age groupsCase-control studyMultivariate logistic modelThromboprophylaxis practiceVenous thrombosesPrimary outcomeRisk stratificationThromboprophylaxis trialCatheterization dataMobility scoreAge groupsSecondary analysisDays durationThromboembolismLonger lengthAssociative statisticsChildrenDurationHospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study
Havlicek E, Goldman Z, Faustino E, Ignjatovic V, Goldenberg N, Sochet A. Hospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study. Journal Of Thrombosis And Haemostasis 2023, 21: 3145-3152. PMID: 37423387, DOI: 10.1016/j.jtha.2023.06.035.Peer-Reviewed Original ResearchConceptsHospital-acquired venous thromboembolismInvasive mechanical ventilationRetrospective cohort studyVenous thromboembolismMechanical ventilationEndotracheal intubationCohort studyIll childrenRisk factorsGeneral pediatric intensive care unit populationPediatric intensive care unit populationConcurrent central venous cathetersIntensive care unit populationExtremity deep venous thrombosisPediatric intensive care unitHypercoagulability risk factorsDeep venous thrombosisCentral venous cathetersIntensive care unitEligible encountersIMV durationPulmonary embolismSecondary outcomesVenous cathetersPrimary outcomeDerivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*
Sanchez-Pinto L, Bennett T, Stroup E, Luo Y, Atreya M, Bubeck Wardenburg J, Chong G, Geva A, Faustino E, Farris R, Hall M, Rogerson C, Shah S, Weiss S, Khemani R. Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*. Pediatric Critical Care Medicine 2023, 24: 795-806. PMID: 37272946, PMCID: PMC10540758, DOI: 10.1097/pcc.0000000000003292.Peer-Reviewed Original ResearchMultiple organ dysfunction syndromeSepsis-associated multiple organ dysfunction syndromePersistent hypoxemiaAdjuvant therapySepsis phenotypesSevere pediatric acute respiratory distress syndromePediatric acute respiratory distress syndromeMulticenter observational cohort studyAcute respiratory distress syndromePropensity score-matched analysisCommon adjuvant therapyHeterogeneity of sepsisOrgan dysfunction syndromeObservational cohort studyRespiratory distress syndromeHospital mortalityCohort studyDysfunction syndromeSystemic inflammationDistress syndromeOrgan dysfunctionSeptic shockClinical syndromeCommon therapyClinical relevanceTight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials
Zinter M, Markovic D, Asaro L, Nadkarni V, McQuillen P, Sinha P, Matthay M, Jeschke M, Agus M, Sapru A, Agus M, Coughlin-Wells K, Hughes K, French J, Fitzgerald M, Srinivasan V, Sisko M, Chima R, Howard K, Jones R, Thomas N, Spear D, Li S, Pinto A, Eldridge P, Newth C, Kwok J, Hassinger A, Qiao H, Bysani K, Monjure T, Faustino E, Tala J, Kandil S, Quinn T, Hirshberg E, Lilley J, Wintergerst K, Sullivan J, Lee K, Schwarz A, Flores C, Vargas-Shiraishi O, Sorce L, Marsillio L, Shukla A, Cvijanovich N, Flori H, Brumfield B, Stone C, Dahmer M, Jayachandran C, Federman M, Wong K, Vangala S, Pellegrini M, Balliu B, Gala K, Kirkpatrick T, Deshmukh T, Mareboina M, Do N, Ashtari N, Ratiu A, Nett S, Singleton M, Jarvis D, McNally M, Martini K, Pinto N, Chong G, Rodgers C, Viteri S, John R, Mulholland T, Pellicciotti G, Sapru A, McQuillen P, Zinter M, Goel S, Alkhouli M, McKenzie A, Villarreal-Chico D. Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 945-949. PMID: 36656551, PMCID: PMC10111993, DOI: 10.1164/rccm.202210-1988le.Peer-Reviewed Original Research
2022
Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children.
Sochet A, Havlicek E, Faustino E, Goldenberg N. Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children. Hospital Pediatrics 2022, 12: 1099-1109. PMID: 36349533, DOI: 10.1542/hpeds.2022-006697.Peer-Reviewed Original ResearchConceptsHospital-acquired venous thromboembolismDeep venous thrombosisMechanical ventilationMultivariable logistic regressionIll childrenVenous thromboembolismCohort studyVenous thrombosisRegistry-based cohort studyExtremity deep venous thrombosisLogistic regressionHA-VTE eventsInvasive mechanical ventilationRetrospective cohort studyVTE risk factorsCentral venous catheterizationYears of ageHospital dischargePulmonary embolismPrimary outcomeVenous catheterizationRisk factorsClinical trialsProspective validationSystem registryPractical considerations and consensus opinion for children’s hospital–based inpatient hemostasis and thrombosis (HAT) consultative services: Communication from the ISTH SSC Subcommittee on Pediatric/Neonatal Thrombosis and Hemostasis
Woods GM, Raffini L, Brandão LR, Jaffray J, Branchford BR, Ng CJ, Sartain SE, Pak J, Male C, Zia A, Rizzi M, Sirachainan N, Faustino E, Carpenter SL, Goldenberg NA. Practical considerations and consensus opinion for children’s hospital–based inpatient hemostasis and thrombosis (HAT) consultative services: Communication from the ISTH SSC Subcommittee on Pediatric/Neonatal Thrombosis and Hemostasis. Journal Of Thrombosis And Haemostasis 2022, 20: 2151-2158. PMID: 35748322, DOI: 10.1111/jth.15798.Peer-Reviewed Original ResearchConceptsTertiary care referral centerConsensus opinionAnticoagulation management serviceManagement of patientsNumerous therapeutic advancesDisorders of hemostasisISTH SSC SubcommitteeNeonatal thrombosisFellowship training programsInpatient managementReferral centerAdult hospitalsPediatric institutionTherapeutic advancesPediatric dataHAT patientsMedical complexityInpatient settingThrombosisHemostasisConsultative servicesPatientsTraining programCurrent practiceComplicationsIntroduction of Hydroxyurea Therapy to a Cohort of Sickle Cell Patients in Northern Haiti
Paul-Hanna M, Joseph W, Mondesir W, Faustino EVS, Canarie MF. Introduction of Hydroxyurea Therapy to a Cohort of Sickle Cell Patients in Northern Haiti. Journal Of Pediatric Hematology/Oncology 2022, 44: 351-353. PMID: 35180761, DOI: 10.1097/mph.0000000000002431.Peer-Reviewed Original ResearchConceptsSickle cell anemiaCell anemiaRate of hospitalizationSickle cell patientsHydroxyurea therapyHU therapySignificant complicationsCell patientsHigh prevalenceTherapyComplicationsStudy periodYoung adultsPrincipal outcomeHospitalizationPatientsAnemiaCohortPrevalenceHydroxyureaTreatmentNorthern HaitiMorbidityClinicHospital
2021
Pharmacologic restraint during ED mental health visits
Faustino E. Pharmacologic restraint during ED mental health visits. The Journal Of Pediatrics 2021, 236: 1-3. DOI: 10.1016/j.jpeds.2021.07.028.Peer-Reviewed Original ResearchDesign and Development of A-vent: A Low-Cost Ventilator with Cost-Effective Mobile Cloud Caching and Embedded Machine Learning
Cabacungan P, Oppus C, Cabacungan N, Mamaradlo J, Santiago P, Mercado N, Faustino E, Tangonan G. Design and Development of A-vent: A Low-Cost Ventilator with Cost-Effective Mobile Cloud Caching and Embedded Machine Learning. 2021, 00: 1-8. DOI: 10.1109/tensymp52854.2021.9550920.Peer-Reviewed Original ResearchEmbedded MachineCloud systemsDetection modelData processingAir flow rateWaveform eventsFail-safe operationPercent accuracyMachineViable standardBattery systemTest bagVibration anomaliesAir pressure dataPressure sensorData pointsElectronic componentsPrototype operationFuture workAcoustic signatureFlow rateLow-cost ventilatorPrototypeCachingCompression patternsPerformance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT)
Hirshberg E, Alexander J, Asaro L, Coughlin-Wells K, Steil G, Spear D, Stone C, Nadkarni V, Agus M, Investigators H, Agus M, Wypij D, Asaro L, Nadkarni V, Srinivasan V, Biagas K, Mourani P, Chima R, Thomas N, Li S, Pinto A, Newth C, Hassinger A, Bysani K, Rehder K, Faustino E, Kandil S, Hirshberg E, Wintergerst K, Schwarz A, Bagdure D, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Pinto N, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin J, Jouvet P, Yanay O, Allen C, Luckett P, Fackler J, Rozen T. Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT). CHEST Journal 2021, 160: 919-928. PMID: 33932465, PMCID: PMC8449010, DOI: 10.1016/j.chest.2021.04.049.Peer-Reviewed Original ResearchConceptsLung Failure-Pediatric INsulin Titration trialBlood glucose targetsCritical care trialsManagement of hyperglycemiaTitration trialCare trialsGlucose targetsCDS toolElectronic clinical decision support systemLow complianceBlood glucose metricsIll pediatric patientsObservational retrospective studyElectronic decision support systemClinical decision support systemInotropic supportPediatric patientsPatient factorsRetrospective studyClinician factorsIll childrenGlucose metricsPatientsTherapeutic interventionsStudy designAssociation of Race and Ethnicity with Sedation Management in Pediatric Intensive Care.
Natale J, Asaro L, Joseph J, Ulysse C, Ascenzi J, Bowens C, Wypij D, Curley M, Curley M, Wypij D, Allen G, Angus D, Asaro L, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care. Annals Of The American Thoracic Society 2021, 18: 93-102. PMID: 32776853, PMCID: PMC7780975, DOI: 10.1513/annalsats.201912-872oc.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlack PeopleChildChild, PreschoolCritical CareEthnicityFemaleHealthcare DisparitiesHispanic or LatinoHumansInfantInfant, NewbornIntensive Care Units, PediatricMaleMulticenter Studies as TopicPainPain ManagementRandomized Controlled Trials as TopicRespiration, ArtificialRespiratory InsufficiencyWhite PeopleConceptsSedation managementPain managementClinical trialsU.S. pediatric intensive care unitsPediatric intensive care unitCluster-randomized clinical trialRacial disparitiesIatrogenic withdrawal syndromeAcute respiratory failureEpisodes of painPlanned secondary analysisIntensive care unitPediatric intensive careAssociation of raceEthnicity groupsNon-Hispanic blacksPercentage of daysRespiratory failureUsual careCumulative dosingPediatric patientsWithdrawal syndromeBlack patientsCare unitIntervention arm
2020
623: Risk Assessment Scoring for Venous Thromboembolism in Critically Ill Adolescents
Gupta A, Faustino E. 623: Risk Assessment Scoring for Venous Thromboembolism in Critically Ill Adolescents. Critical Care Medicine 2020, 49: 305-305. DOI: 10.1097/01.ccm.0000728380.57915.da.Peer-Reviewed Original ResearchIntravenous magnesium for asthma exacerbation
Faustino E. Intravenous magnesium for asthma exacerbation. The Journal Of Pediatrics 2020, 220: 1-3. DOI: 10.1016/j.jpeds.2020.03.045.Peer-Reviewed Original Research