Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock
Atreya M, Bennett T, Geva A, Faustino E, Rogerson C, Lutfi R, Cvijanovich N, Bigham M, Nowak J, Schwarz A, Baines T, Haileselassie B, Thomas N, Luo Y, Sanchez-Pinto L, Investigators F. Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock. Pediatric Critical Care Medicine 2024, 25: 512-517. PMID: 38465952, PMCID: PMC11153020, DOI: 10.1097/pcc.0000000000003499.Peer-Reviewed Original ResearchElectronic health recordsMultiple organ dysfunction syndromePediatric septic shock patientsSeptic shock patientsRisk strataElectronic health record dataSepsis phenotypesShock patientsPersistent multiple organ dysfunction syndromeAssociated with poor clinical outcomesDegree of systemic inflammationIncreased adjusted oddsHigh riskOrgan dysfunction syndromePoor clinical outcomesHealth recordsReceiver operating characteristic curveHigh-risk stratumArea under the receiver operating characteristic curveCritically ill patientsPredictive of deathSeverity of illnessAdjusted oddsIdentification of childrenOperating characteristics curve