2003
The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle
Wang T. The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle. Journal Of Pharmacology And Experimental Therapeutics 2003, 304: 833-840. PMID: 12538840, DOI: 10.1124/jpet.102.043380.Peer-Reviewed Original ResearchConceptsLoop of HenleUrine volumeIn vivo microperfusion techniquesCa(2+ATP-sensitive potassium channelsRenal electrolyte transportK channel openerPotassium channel opener minoxidilGlomerular filtration rateApical K(+Fractional Na(+Natriuretic effectAntinatriuretic actionsRenal clearanceFiltration ratePotassium channelsUrinary excretionIncreased fluidAscending limbIntravenous injectionBlood pressureMicroperfusion techniqueHenlePerfusion fluidDecreased Na(+
2002
Role of iNOS and eNOS in modulating proximal tubule transport and acid-base balance
Wang T. Role of iNOS and eNOS in modulating proximal tubule transport and acid-base balance. American Journal Of Physiology. Renal Physiology 2002, 283: f658-f662. PMID: 12217856, DOI: 10.1152/ajprenal.00243.2001.Peer-Reviewed Original ResearchConceptsNeuronal nitric oxide synthaseProximal tubulesEndothelial NOSInducible NOSKnockout miceHCO transportEndothelial NOS knockout miceINOS knockout miceMice lacking neuronal nitric oxide synthaseL-N(6)-(1-iminoethyl) lysineInducible NOS knockoutProximal tubule transportNOS knockout miceKidney proximal tubulesWild-typeIsoforms of NOSWild-type controlsNitric oxide synthaseTubule transportMetabolic acidosisModulate Na(+Acid-base statusJ(HCO3Acid-base balanceFluid absorption
2000
Defective fluid and HCO3 − absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice
Wang T, Inglis F, Kalb R. Defective fluid and HCO3 − absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice. American Journal Of Physiology. Renal Physiology 2000, 279: f518-f524. PMID: 10966931, DOI: 10.1152/ajprenal.2000.279.3.f518.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAnimalsBicarbonatesBiological TransportBlood Gas AnalysisBody FluidsElectrolytesEnzyme InhibitorsInjections, IntravenousKidney Tubules, ProximalMiceMice, Inbred C57BLMice, KnockoutNG-Nitroarginine Methyl EsterNitric Oxide SynthaseNitric Oxide Synthase Type IPotassiumSodiumConceptsNNOS knockout miceWild-type miceL-NAMEProximal tubulesMetabolic acidosisAbsorption of fluidDecreased absorption of fluidBlood pressureIncreased mean blood pressureResponse to L-NAMEWild-type control animalsFluid absorptionAdministration of L-NAMEIn situ microperfusionProximal tubule transportNeuronal nitric oxide synthaseLuminal perfusion solutionMean blood pressureRenal clearance techniquesNitric oxide synthaseRates of HCO(3)(-Urinary Na(+HCO3- absorptionRegulation of acid-base balanceTubule transport
1996
Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney
Wang T, Giebisch G. Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney. American Journal Of Physiology 1996, 271: f143-f149. PMID: 8760255, DOI: 10.1152/ajprenal.1996.271.1.f143.Peer-Reviewed Original ResearchConceptsEffects of Ang IIAng IILate distal tubuleDistal tubulesDecreased JvAngiotensin IIHigher dose of Ang IILow doses of angiotensin IILuminal application of amilorideAmiloride-sensitive Na+ transportDose of Ang IIRat kidneyHCO3- transportAddition of ANG IIDoses of angiotensin IIEffects of angiotensin IIApplication of amilorideStimulate Na+/H+ exchangeProximal tubules of rat kidneyDistal convoluted tubuleLuminal administrationNa+ channelsNa+/H+ exchangeDistal nephronIntravenous infusion
1995
Effects of chronic hyperfiltration on proximal tubule bicarbonate transport and cell electrolytes
Ohno A, Beck F, Pfaller W, Giebisch G, Wang T. Effects of chronic hyperfiltration on proximal tubule bicarbonate transport and cell electrolytes. Kidney International 1995, 48: 712-721. PMID: 7474656, DOI: 10.1038/ki.1995.342.Peer-Reviewed Original ResearchConceptsK-ATPase activityProximal tubulesUNX ratsNa/H exchangeBicarbonate absorptionBicarbonate transportResponse to unilateral nephrectomyNa,K-ATPase activityBasolateral ion transportStimulation of bicarbonateBasolateral NaChronic hyperfiltrationMaximal transport rateRemnant kidneyUnilateral nephrectomyCortical tubulesFiltration rateRenal clearanceUNXBicarbonate levelsK-ATPaseRubidium uptakeH secretionFluid absorptionCell ion concentrations