2024
BSLM-03 BRANCHED-CHAIN KETO ACIDS PROMOTE AN IMMUNE-SUPPRESSIVE AND NEURODEGENERATIVE MICROENVIRONMENT IN LEPTOMENINGEAL DISEASE
Khaled M, Ren Y, Kundalia R, Alhaddad H, Chen Z, Wallace G, Evernden B, Ospina O, Hall M, Liu M, Darville L, Izumi V, Chen Y, Pilon-Thomas S, Stewart P, Koomen J, Corallo S, Jain M, Robinson T, Locke F, Forsyth P, Smalley I. BSLM-03 BRANCHED-CHAIN KETO ACIDS PROMOTE AN IMMUNE-SUPPRESSIVE AND NEURODEGENERATIVE MICROENVIRONMENT IN LEPTOMENINGEAL DISEASE. Neuro-Oncology Advances 2024, 6: i5-i5. PMCID: PMC11296858, DOI: 10.1093/noajnl/vdae090.014.Peer-Reviewed Original ResearchChimeric antigen receptorLeptomeningeal diseaseBranched-chain keto acidsSodium phenylbutyrateCerebrospinal fluidSurvival outcomesT cellsBreast cancerEfficacy of CAR T-cell therapyAnti-tumor immune environmentCAR-T cell therapyMurine model of breast cancerResponse to immune therapyModel of breast cancerFunction of T lymphocytesT-cell therapyDysfunctional T cellsComprehensive multi-omics analysisPoor survival outcomesCerebrospinal fluid of patientsAnalysis of cerebrospinal fluidPreclinical rationaleImmune therapyImmune environmentNeurological deterioration
2021
Immune Cell Infiltrates of the Tumor Microenvironment and Radiosensitivity of Recurrent Glioblastomas and Their Association With Outcome
Rishi A, Mohammadi H, Martir D, Welsh E, Robinson T, Oliver D, Eschrich S, Torres-Roca J, Yu H, Grass D, Ahmed K. Immune Cell Infiltrates of the Tumor Microenvironment and Radiosensitivity of Recurrent Glioblastomas and Their Association With Outcome. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: s123. DOI: 10.1016/j.ijrobp.2021.07.281.Peer-Reviewed Original ResearchImmune cell infiltratesProgression-free survivalAffected overall survivalOverall survivalHelper T cellsRadiosensitivity indexCell infiltrateClinical trialsT cellsPrimary GBMMedian progression-free survivalLack of monocytesNLR/PLRHigh expressionPoor prognostic factorCurrent smoking statusKaplan-Meier estimatesLog-rank testLow-grade gliomasMATERIAL/METHODSAssociation of factorsICI subtypesRGBM patientsAdjuvant radiotherapyFree survival