BSLM-03 BRANCHED-CHAIN KETO ACIDS PROMOTE AN IMMUNE-SUPPRESSIVE AND NEURODEGENERATIVE MICROENVIRONMENT IN LEPTOMENINGEAL DISEASE
Khaled M, Ren Y, Kundalia R, Alhaddad H, Chen Z, Wallace G, Evernden B, Ospina O, Hall M, Liu M, Darville L, Izumi V, Chen Y, Pilon-Thomas S, Stewart P, Koomen J, Corallo S, Jain M, Robinson T, Locke F, Forsyth P, Smalley I. BSLM-03 BRANCHED-CHAIN KETO ACIDS PROMOTE AN IMMUNE-SUPPRESSIVE AND NEURODEGENERATIVE MICROENVIRONMENT IN LEPTOMENINGEAL DISEASE. Neuro-Oncology Advances 2024, 6: i5-i5. PMCID: PMC11296858, DOI: 10.1093/noajnl/vdae090.014.Peer-Reviewed Original ResearchChimeric antigen receptorLeptomeningeal diseaseBranched-chain keto acidsSodium phenylbutyrateCerebrospinal fluidSurvival outcomesT cellsBreast cancerEfficacy of CAR T-cell therapyAnti-tumor immune environmentCAR-T cell therapyMurine model of breast cancerResponse to immune therapyModel of breast cancerFunction of T lymphocytesT-cell therapyDysfunctional T cellsComprehensive multi-omics analysisPoor survival outcomesCerebrospinal fluid of patientsAnalysis of cerebrospinal fluidPreclinical rationaleImmune therapyImmune environmentNeurological deterioration