Phase II Trial of Reduced-Intensity Fludarabine, Melphalan 70 Mg/m2, and Total Body Irradiation Conditioning Results in Favorable Outcomes with Haploidentical Donor Peripheral Blood Stem Cell Transplant
Elmariah H, Kim J, DiMaggio E, Gonzalez R, Kim J, Kim J, Mishra A, Faramand R, Perez L, Lazaryan A, Khimani F, Liu H, Ochoa L, Nieder M, Figura N, Robinson T, Nishihori T, Anasetti C, Pidala J, Bejanyan N. Phase II Trial of Reduced-Intensity Fludarabine, Melphalan 70 Mg/m2, and Total Body Irradiation Conditioning Results in Favorable Outcomes with Haploidentical Donor Peripheral Blood Stem Cell Transplant. Transplantation And Cellular Therapy 2024, 30: s58-s59. DOI: 10.1016/j.jtct.2023.12.093.Peer-Reviewed Original ResearchDisease-free survivalNon-relapse mortalityPost-transplant cyclophosphamidePhase II trialHaplo-PBSCTHematopoietic cell transplantationRate of relapseCumulative incidenceHCT-CIPrimary endpointCumulative incidence of grade II–IV acute GVHDCumulative incidence of non-relapse mortalityIncidence of grade II-IV acute GVHDGrade II-IV acute GVHDGVHD-free relapse-free survivalIncidence of non-relapse mortalityModerate to severe chronic GVHDHematopoietic cell transplantation comorbidity indexMedian follow-up timeChronic GVHD ratesGraft failure eventsHCT-CI scoreSevere chronic GVHDRelapse-free survivalRisk of relapse