Iron homeostasis governs erythroid phenotype in polycythemia vera
Bennett C, Jackson V, Pettikiriarachchi A, Hayman T, Schaeper U, Moir-Meyer G, Fielding K, Ataide R, Clucas D, Baldi A, Garnham A, Li-Wai-Suen C, Loughran S, Baxter E, Green A, Alexander W, Bahlo M, Burbury K, Ng A, Pasricha S. Iron homeostasis governs erythroid phenotype in polycythemia vera. Blood 2023, 141: 3199-3214. PMID: 36928379, PMCID: PMC10646816, DOI: 10.1182/blood.2022016779.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesIron homeostasisErythroid phenotypePolycythemia veraRegulator of systemic iron homeostasisGenetic dissectionAssociation studiesSystemic iron homeostasisUK Biobank dataHFE variantsErythroid diseaseMouse model of PVExpression of hepcidinBiobank dataLife-threatening thrombotic eventsActivating mutationsHepcidin expressionPathophysiology of PVPhenotypeHomeostasisMyeloproliferative neoplasmsThrombotic eventsHepcidin upregulationTherapeutic strategiesInflammatory cytokines