2021
Reinforcement learning detuned in addiction: integrative and translational approaches
Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends In Neurosciences 2021, 45: 96-105. PMID: 34920884, PMCID: PMC8770604, DOI: 10.1016/j.tins.2021.11.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDecision-making deficitsPathophysiology of addictionDecision-making strategiesBiobehavioral mechanismsAddictionReinforcement learningDecision-making processDrug useTranslational approachComputational componentsDeficitsLearningDifferent componentsBiological mechanismsOutcomesFindingsRecent studiesBehaviorStudy
2018
Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task
Groman SM, Massi B, Mathias SR, Curry DW, Lee D, Taylor JR. Neurochemical and Behavioral Dissections of Decision-Making in a Rodent Multistage Task. Journal Of Neuroscience 2018, 39: 295-306. PMID: 30413646, PMCID: PMC6325257, DOI: 10.1523/jneurosci.2219-18.2018.Peer-Reviewed Original ResearchConceptsMultistage taskBehavioral platformDopamine toneDecision Making TaskValue-based choiceDecision-making taskNovel behavioral paradigmModel-based learningConsequences of actionsReinforcement learning systemNeuroscience studiesBehavioral paradigmsBiobehavioral mechanismsVentral striatumNeurobehavioral levelBehavioral dissectionNovel analytic approachCortex correlatesRetrospective appraisalChoice behaviorTaskBehavioral mechanismsMental disordersModel-based systemLearning
2011
Dorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination Learning
Groman SM, Lee B, London ED, Mandelkern MA, James AS, Feiler K, Rivera R, Dahlbom M, Sossi V, Vandervoort E, Jentsch JD. Dorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination Learning. Journal Of Neuroscience 2011, 31: 7291-7299. PMID: 21593313, PMCID: PMC3114883, DOI: 10.1523/jneurosci.0363-11.2011.Peer-Reviewed Original ResearchConceptsLike receptor availabilityIndividual differencesDiscrimination learningBehavioral flexibilitySpecific neurocognitive mechanismsVisual discrimination problemsBehavioral sensitivityReceptor availabilityNeurocognitive mechanismsReward sensitivityBehavioral performanceNeural mechanismsVisual discriminationNeuropsychiatric disordersPositive reinforcementReversal phaseEnvironmental contingenciesThree-choiceNumber of trialsPhenotypic dimensionsPsychiatric conditionsFeedback sensitivityLearningElectrophysiological findingsDisorders