2024
Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion
Mak A, Matouk C, Avery E, Behland J, Haider S, Frey D, Madai V, Vajkoczy P, Griessenauer C, Zand R, Hendrix P, Abedi V, Sanelli P, Falcone G, Petersen N, Sansing L, Sheth K, Payabvash S, Malhotra A. Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion. PLOS ONE 2024, 19: e0304962. PMID: 38870240, PMCID: PMC11175522, DOI: 10.1371/journal.pone.0304962.Peer-Reviewed Original ResearchConceptsDiffusion-weighted imagingLarge vessel occlusionIrreversible ischemic changesPoor functional outcomeFunctional outcomesIschemic changesInfarct volumeAlberta Stroke Program Early CT ScorePredicting poor functional outcomeVessel occlusionFollow-up diffusion-weighted imagingAnterior circulation LVO strokeCTA source imagesReceiver operating characteristic curveExpert human readersPredicting final infarctionASPECTS regionsAdmission CTANon-inferior performanceBaseline CTACT scoreFinal infarctEndovascular therapyHU attenuationValidation cohort
2023
Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally
Bobba P, Weber C, Malhotra A, Bahtiyar M, Copel J, Taylor S, Ment L, Payabvash S. Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally. Scientific Reports 2023, 13: 21514. PMID: 38057452, PMCID: PMC10700578, DOI: 10.1038/s41598-023-48963-z.Peer-Reviewed Original ResearchUtility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently
Andrijauskis D, Woolf G, Kuehne A, Al-Dasuqi K, Silva C, Payabvash S, Malhotra A. Utility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently. American Journal Of Neuroradiology 2023, 44: 1208-1211. PMID: 37652579, PMCID: PMC10549952, DOI: 10.3174/ajnr.a7976.Peer-Reviewed Original ResearchMeSH KeywordsBrainChildContrast MediaEpilepsyGadoliniumHumansMagnetic Resonance ImagingRetrospective StudiesSeizuresConceptsSeizure presentationMR imagingConsecutive pediatric patientsNew-onset seizuresEvaluation of seizuresIschemic/hypoxicImaging of patientsBrain MR imagingGadolinium-based contrast agentsNoncontrast studyAcute onsetHippocampal sclerosisPediatric seizuresPatient agePediatric patientsNormal findingsIntracranial hemorrhageEmergency departmentVascular anomaliesInpatient unitGadolinium contrastPatientsNeurodevelopmental lesionAdditive benefitSeizuresIdentification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRetrospective StudiesWhite MatterConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation index
2022
Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest
Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain InjuriesCritical IllnessFemaleHeart ArrestHumansHypoxia-Ischemia, BrainMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesConceptsCardiac arrestBrain injuryHypoxic-ischemic brain injuryAdverse neurological outcomesIschemic brain injurySingle-center studyBrain magnetic resonanceBrain injury severityBoard-certified neuroradiologistsLow-field MRIFLAIR signal intensityNeurological outcomeCA patientsIll patientsMRI findingsCA survivorsCenter studyMRI examinationsClinical careHigh riskInjury severityPatientsSignal intensityBedside monitoringMR imagingCT angiographic radiomics signature for risk stratification in anterior large vessel occlusion stroke
Avery EW, Behland J, Mak A, Haider SP, Zeevi T, Sanelli PC, Filippi CG, Malhotra A, Matouk CC, Griessenauer CJ, Zand R, Hendrix P, Abedi V, Falcone GJ, Petersen N, Sansing LH, Sheth KN, Payabvash S. CT angiographic radiomics signature for risk stratification in anterior large vessel occlusion stroke. NeuroImage Clinical 2022, 34: 103034. PMID: 35550243, PMCID: PMC9108990, DOI: 10.1016/j.nicl.2022.103034.Peer-Reviewed Original ResearchMeSH KeywordsArterial Occlusive DiseasesHumansRetrospective StudiesRisk AssessmentStrokeThrombectomyTomography, X-Ray ComputedTreatment OutcomeConceptsLarge vessel occlusion strokeIndependent cohortPrognostication toolsMechanical thrombectomyRisk stratificationOcclusion strokeExternal cohortAnterior circulation large vessel occlusion strokeOutcome predictionAcute stroke triageAnterior circulation territoryRadiomic featuresTime of admissionGeisinger Medical CenterLVO stroke patientsReliable clinical informationSignificant differencesAdmission CTAStroke patientsPrognostic informationFavorable outcomeStroke triageTreatment decisionsMedical CenterRadiomics signature
2021
Similar admission NIHSS may represent larger tissue-at-risk in patients with right-sided versus left-sided large vessel occlusion
Mak A, Matouk C, Avery EW, Behland J, Frey D, Madai VI, Vajkoczy P, Malhotra A, Karam A, Sanelli P, Falcone GJ, Petersen NH, Sansing L, Sheth KN, Payabvash S. Similar admission NIHSS may represent larger tissue-at-risk in patients with right-sided versus left-sided large vessel occlusion. Journal Of NeuroInterventional Surgery 2021, 14: 985-991. PMID: 34645705, DOI: 10.1136/neurintsurg-2021-017785.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaCerebral InfarctionHumansRetrospective StudiesStrokeThrombectomyTreatment OutcomeConceptsLarge vessel occlusionFinal infarct volumeLarger final infarct volumeWorse discharge outcomesInfarct volumeAdmission NIHSSDischarge outcomesVessel occlusionScale scoreMultivariate analysisAnterior large vessel occlusionLower admission NIHSS scoreHealth Stroke Scale scoreAdmission National InstitutesAdmission stroke severityPoor discharge outcomeStroke Scale scoreLarger infarct volumesAdmission NIHSS scoreRankin Scale scoreVoxel-wise analysisIncomplete reperfusionInfarct distributionOcclusion sideNIHSS scoreEarly head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy?
Beekman R, Maciel CB, Ormseth CH, Zhou SE, Galluzzo D, Miyares LC, Torres-Lopez VM, Payabvash S, Mak A, Greer DM, Gilmore EJ. Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy? Resuscitation 2021, 165: 68-76. PMID: 34147572, DOI: 10.1016/j.resuscitation.2021.06.004.Peer-Reviewed Original ResearchMeSH KeywordsGray MatterHeart ArrestHumansPrognosisReproducibility of ResultsRetrospective StudiesTomography, X-Ray ComputedConceptsGray-white matter ratioHCT findingsArrest patientsInter-rater reliabilityPost-cardiac arrest patientsTertiary care academic medical centerEarly head CTPost-CA carePost-CA patientsCardiac arrest patientsHalf of casesAcademic medical centerElectronic medical recordsWithdrawal of lifeNeurophysiologic testingSpontaneous circulationInjury burdenMedical recordsHead CTTherapeutic decisionsMedical CenterPatientsNeurointensivistsHctTemperature management
2020
Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke
Al-Dasuqi K, Payabvash S, Torres-Flores GA, Strander SM, Nguyen CK, Peshwe KU, Kodali S, Silverman A, Malhotra A, Johnson MH, Matouk CC, Schindler JL, Sansing LH, Falcone GJ, Sheth KN, Petersen NH. Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke. Stroke 2020, 51: e193-e202. PMID: 32781941, PMCID: PMC7484023, DOI: 10.1161/strokeaha.120.029892.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArterial Occlusive DiseasesCerebral InfarctionCohort StudiesCollateral CirculationComputed Tomography AngiographyEndovascular ProceduresFemaleHumansInfarction, Middle Cerebral ArteryLinear ModelsMagnetic Resonance AngiographyMaleMiddle AgedReperfusionRetrospective StudiesStrokeThrombectomyTreatment OutcomeWhite MatterConceptsLarge vessel occlusion strokeFinal infarct volumeCollateral statusPoor collateral statusFavorable outcomeInfarct distributionInfarct volumeReperfusion successIndependent predictorsOcclusion strokeInternal capsuleAnterior circulation large vessel occlusion ischemic strokeLarge vessel occlusion ischemic strokeDeep white matter tractsBaseline collateral statusBorder-zone infarctionEarly favorable outcomeEarly functional outcomesRankin Scale scoreCohort of patientsDegree of reperfusionLarge vessel occlusionComputed tomography angiographyDeep white matterMagnetic resonance imagingChoice of imaging modality for pre-treatment staging of head and neck cancer impacts TNM staging
Mur T, Sambhu KM, Mahajan A, Payabvash S, Fernandez J, Edwards HA. Choice of imaging modality for pre-treatment staging of head and neck cancer impacts TNM staging. American Journal Of Otolaryngology 2020, 41: 102662. PMID: 32858370, DOI: 10.1016/j.amjoto.2020.102662.Peer-Reviewed Original ResearchConceptsPET/CTLow-dose nonenhanced CTDistant metastasisChest CTNeck cancerNonenhanced CTF-fluorodeoxyglucose positron emission tomographyF-FDG PET/CTDiagnostic chest CTDistant metastatic diseaseInitiation of therapyRetrospective cohort studyPre-treatment stagingTertiary care settingSignificant differencesPositron emission tomographyMetastatic diseaseCohort studyOncologic treatmentTNM stagingInaccurate stagingNeck radiologistsCare settingsSingle patientPatientsPET/CT radiomics signature of human papilloma virus association in oropharyngeal squamous cell carcinoma
Haider SP, Mahajan A, Zeevi T, Baumeister P, Reichel C, Sharaf K, Forghani R, Kucukkaya AS, Kann BH, Judson BL, Prasad ML, Burtness B, Payabvash S. PET/CT radiomics signature of human papilloma virus association in oropharyngeal squamous cell carcinoma. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 47: 2978-2991. PMID: 32399621, DOI: 10.1007/s00259-020-04839-2.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaMetastatic cervical lymph nodesCervical lymph nodesLymph nodesSquamous cell carcinomaPrimary tumorPET/CTHPV associationCell carcinomaRadiomics signatureVolume of interestHuman papilloma virus associationHuman papillomavirus associationMulti-national cohortNon-contrast CTHPV statusFDG-PETExternal cohortVirus associationFinal modelTumorsRadiomic featuresCTSignificant differencesLesion features
2018
Volumetric voxelwise apparent diffusion coefficient histogram analysis for differentiation of the fourth ventricular tumors
Payabvash S, Tihan T, Cha S. Volumetric voxelwise apparent diffusion coefficient histogram analysis for differentiation of the fourth ventricular tumors. The Neuroradiology Journal 2018, 31: 554-564. PMID: 30230411, PMCID: PMC6243467, DOI: 10.1177/1971400918800803.Peer-Reviewed Original ResearchA user-guided tool for semi-automated cerebral microbleed detection and volume segmentation: Evaluating vascular injury and data labelling for machine learning
Morrison MA, Payabvash S, Chen Y, Avadiappan S, Shah M, Zou X, Hess CP, Lupo JM. A user-guided tool for semi-automated cerebral microbleed detection and volume segmentation: Evaluating vascular injury and data labelling for machine learning. NeuroImage Clinical 2018, 20: 498-505. PMID: 30140608, PMCID: PMC6104340, DOI: 10.1016/j.nicl.2018.08.002.Peer-Reviewed Original ResearchConceptsData labelingTraining dataHigh-level feature extractionVolume segmentationComputer-aided detection algorithmComputer-aided detection methodsGround truth labelingCerebral microbleed detectionFalse positivesMachine learningFeature extractionSegmentation resultsDetection algorithmSophisticated machineTime usersAlgorithm performanceCMB detectionComputer aidMicrobleed detectionSegmentationTest setDetection methodSuperior performanceExtensive research effortsMachineDifferentiation of Cerebellar Hemisphere Tumors: Combining Apparent Diffusion Coefficient Histogram Analysis and Structural MRI Features
Payabvash S, Tihan T, Cha S. Differentiation of Cerebellar Hemisphere Tumors: Combining Apparent Diffusion Coefficient Histogram Analysis and Structural MRI Features. Journal Of Neuroimaging 2018, 28: 656-665. PMID: 30066449, DOI: 10.1111/jon.12550.Peer-Reviewed Original Research
2017
Multivariate Prognostic Model of Acute Stroke Combining Admission Infarct Location and Symptom Severity: A Proof-of-Concept Study
Payabvash S, Benson JC, Tyan AE, Taleb S, McKinney AM. Multivariate Prognostic Model of Acute Stroke Combining Admission Infarct Location and Symptom Severity: A Proof-of-Concept Study. Journal Of Stroke And Cerebrovascular Diseases 2017, 27: 936-944. PMID: 29198948, DOI: 10.1016/j.jstrokecerebrovasdis.2017.10.034.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArea Under CurveBrainBrain IschemiaBrain MappingDatabases, FactualDecision Support TechniquesDiffusion Magnetic Resonance ImagingDisability EvaluationFemaleHumansLogistic ModelsMaleMesencephalonMiddle AgedMultivariate AnalysisOdds RatioPatient AdmissionPonsPredictive Value of TestsProof of Concept StudyReproducibility of ResultsRetrospective StudiesRisk FactorsROC CurveSeverity of Illness IndexStrokeTime FactorsTreatment OutcomeConceptsDisability/deathMidbrain/ponsAcute ischemic stroke patientsIschemic stroke patientsAdmission NIHSS scoreStroke patientsNIHSS scoreIndependent predictorsInfarct locationScale scoreHealth Stroke Scale scoreHigher admission NIHSS scoresModified Rankin Scale scoreSymptom severityAdmission stroke severityBaseline functional disabilityLarger infarct volumesStroke Scale scoreRankin Scale scoreHours of onsetAcute ischemic infarctMultivariate prognostic modelMajor arterial occlusionHypothesis-generating studyVoxel-based analysisCerebral regions preserved by successful endovascular recanalization of acute M1 segment occlusions: a voxel based analysis
Payabvash S, Taleb S, Qureshi AI. Cerebral regions preserved by successful endovascular recanalization of acute M1 segment occlusions: a voxel based analysis. British Journal Of Radiology 2017, 90: 20160869. PMID: 28165757, PMCID: PMC5605076, DOI: 10.1259/bjr.20160869.Peer-Reviewed Original ResearchConceptsM1 segment occlusionDisability/deathSuccessful endovascular recanalizationVoxel-based analysisFinal infarct volumeSuccessful recanalizationSegment occlusionInfarct volumeFavorable outcomePrecentral gyrusCerebral regionsEndovascular recanalizationEndovascular treatmentInsular ribbonSmaller final infarct volumesDays post-symptom onsetMiddle cerebral artery M1 segmentModified Rankin Scale scoreCerebral Infarction scoreTimely reperfusion treatmentEarly clinical outcomesHigh ratePost-symptom onsetSmaller infarct volumesRankin Scale score
2016
CT Perfusion in Acute Lacunar Stroke: Detection Capabilities Based on Infarct Location
Benson JC, Payabvash S, Mortazavi S, Zhang L, Salazar P, Hoffman B, Oswood M, McKinney AM. CT Perfusion in Acute Lacunar Stroke: Detection Capabilities Based on Infarct Location. American Journal Of Neuroradiology 2016, 37: 2239-2244. PMID: 27538902, PMCID: PMC7963880, DOI: 10.3174/ajnr.a4904.Peer-Reviewed Original ResearchInterhemispheric Asymmetry in Distribution of Infarct Lesions among Acute Ischemic Stroke Patients Presenting to Hospital
Payabvash S, Taleb S, Benson JC, McKinney AM. Interhemispheric Asymmetry in Distribution of Infarct Lesions among Acute Ischemic Stroke Patients Presenting to Hospital. Journal Of Stroke And Cerebrovascular Diseases 2016, 25: 2464-2469. PMID: 27373730, DOI: 10.1016/j.jstrokecerebrovasdis.2016.06.019.Peer-Reviewed Original ResearchConceptsRight-sided strokeLeft-sided strokeAcute ischemic stroke patientsEarly clinical outcomesIschemic stroke patientsIschemic infarctInfarct lesionsInsular ribbonVoxel-based analysisClinical outcomesStroke patientsLentiform nucleusScale scoreHealth Stroke Scale scoreModified Rankin Scale scoreSymptom severityStroke risk factorsStroke Scale scoreHours of onsetRankin Scale scoreAcute ischemic infarctRate of treatmentAdmission symptomsSymptomatic infarctsRisk factorsClinical diffusion mismatch better discriminates infarct growth than mean transit time–diffusion weighted imaging mismatch in patients with middle cerebral artery–M1 occlusion and limited infarct core
Nogueira RG, Kemmling A, Souza LM, Payabvash S, Hirsch JA, Yoo AJ, Lev MH. Clinical diffusion mismatch better discriminates infarct growth than mean transit time–diffusion weighted imaging mismatch in patients with middle cerebral artery–M1 occlusion and limited infarct core. Journal Of NeuroInterventional Surgery 2016, 9: 127. PMID: 26957483, DOI: 10.1136/neurintsurg-2014-011602.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCerebral AngiographyCerebral InfarctionCerebrovascular CirculationDiffusion Magnetic Resonance ImagingDisease ProgressionFemaleHumansImage Processing, Computer-AssistedInfarction, Middle Cerebral ArteryMalePredictive Value of TestsRetrospective StudiesStrokeTomography, X-Ray ComputedConceptsClinical-diffusion mismatchMCA M1 occlusionAdmission Alberta Stroke Program Early CT scoreSmall infarct coreBaseline NIHSS scoreInfarct growthNIHSS scoreInfarct coreDiffusion mismatchDWI volumeStroke patientsAlberta Stroke Program Early CT ScoreMiddle cerebral artery M1 occlusionProximal middle cerebral artery occlusionMiddle cerebral artery occlusionMTT lesionsUni-/multivariate analysesBaseline National InstitutesHealth Stroke ScaleAdmission NIHSS scoreCerebral artery occlusionConsecutive stroke patientsOnly independent predictorDWI lesionsStroke Scale
2015
Differentiation of benign from malignant cervical lymph nodes in patients with head and neck cancer using PET/CT imaging
Payabvash S, Meric K, Cayci Z. Differentiation of benign from malignant cervical lymph nodes in patients with head and neck cancer using PET/CT imaging. Clinical Imaging 2015, 40: 101-105. PMID: 26454617, DOI: 10.1016/j.clinimag.2015.09.001.Peer-Reviewed Original ResearchMeSH KeywordsDiagnosis, DifferentialFemaleFluorodeoxyglucose F18Head and Neck NeoplasmsHumansImage-Guided BiopsyLymph NodesLymphatic DiseasesLymphatic MetastasisMaleMiddle AgedMultimodal ImagingNeckPositron-Emission TomographyRadiopharmaceuticalsRetrospective StudiesSensitivity and SpecificityTomography, X-Ray ComputedConceptsHead/neck cancerCervical lymph nodesMalignant cervical lymph nodesLymph nodesNeck cancerPositron emission tomographySUV maxHigh maximum standardized uptake valueBenign cervical lymph nodesMaximum standardized uptake valueLymph node biopsyMalignant lymph nodesMalignant cervical lymphadenopathyPET/CT imagingStandardized uptake valueSUV max valuesShort-axis diameterCervical lymphadenopathyNode biopsyMalignant lymphadenopathyRetrospective studyPatientsUptake valueEmission tomographyCancer