2005
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, Tigelaar RE, Girardi M, Hayday AC. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nature Immunology 2005, 6: 928-937. PMID: 16116470, DOI: 10.1038/ni1239.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinomaCell Line, TumorDisease SusceptibilityDown-RegulationFemaleImmunologic SurveillanceKiller Cells, NaturalLigandsMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNK Cell Lectin-Like Receptor Subfamily KPapillomaReceptors, ImmunologicReceptors, Natural Killer CellSkin NeoplasmsTetradecanoylphorbol AcetateT-LymphocytesTumor BurdenConceptsNKG2D downregulationNK cell-mediated cytotoxicityNatural killer cellsCell-mediated cytotoxicityInnate immune activationT cell defectsNKG2D engagementNatural cytotoxicityKiller cellsImmune activationReceptor NKG2DTumor immunosurveillanceCutaneous carcinogenesisTumor surveillanceT cellsReversible defectsRAE-1Normal epitheliumLigand expressionTumor resistanceCell defectsSustained expressionNKG2DImmunosurveillanceDownregulation
2000
Granulocyte-Macrophage Colony-Stimulating Factor Priming plus Papillomavirus E6 DNA Vaccination: Effects on Papilloma Formation and Regression in the Cottontail Rabbit Papillomavirus-Rabbit Model
Leachman S, Tigelaar R, Shlyankevich M, Slade M, Irwin M, Chang E, Wu T, Xiao W, Pazhani S, Zelterman D, Brandsma J. Granulocyte-Macrophage Colony-Stimulating Factor Priming plus Papillomavirus E6 DNA Vaccination: Effects on Papilloma Formation and Regression in the Cottontail Rabbit Papillomavirus-Rabbit Model. Journal Of Virology 2000, 74: 8700-8708. PMID: 10954571, PMCID: PMC116381, DOI: 10.1128/jvi.74.18.8700-8708.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiopsyCottontail rabbit papillomavirusDisease Models, AnimalDisease-Free SurvivalDNA, ViralGene Transfer TechniquesGenetic VectorsGranulocyte-Macrophage Colony-Stimulating FactorImmunohistochemistryIn Situ HybridizationPapillomaPapillomavirus InfectionsRabbitsTumor Virus InfectionsVaccines, DNAViral VaccinesConceptsGM-CSF primingGM-CSF treatmentDNA vaccinationDNA inoculationPapilloma formationGM-CSFProfessional antigen-presenting cellsMajor histocompatibility complex classDisease-free survivalVaccination-challenge experimentsAntigen-presenting cellsII-positive cellsGranulocyte-macrophage colony-stimulating factorHistocompatibility complex classColony-stimulating factorGranulocyte-macrophage colonyPapilloma volumeVaccination regimenClinical outcomesCutaneous sitesDNA vaccineViral challengePapilloma growthControl rabbitsCombination treatment